Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
N1,N12-Diacetylspermine dihydrochloride is a diacetylated derivative of the polyamine spermine, primarily targeting cellular metabolism. Increased levels of this compound have been associated with cancer development, suggesting its potential role as a biomarker for cancer detection and progression. Research applications include studying the metabolic pathways involved in cancer and evaluating its significance in oncological diagnostics. -
Endogenous Metabolite
H-Phe-Phe-OH is a dipeptide composed of two phenylalanine residues, serving as an important endogenous metabolite. It plays a crucial role in protein synthesis and is a precursor for the neurotransmitter tyrosine, influencing various metabolic pathways. Research applications include studies on amino acid metabolism, neurobiology, and the physiological effects of phenylalanine derivatives. -
Endogenous Metabolite
EpoY is an irreversible inhibitor of tubulin tyrosine carboxypeptidase (TCP), a critical enzyme complex involving vasohibin-1 (VASH1) and small vasohibin binding protein (SVBP). It exhibits an IC50 of approximately 500 nM, leading to a reduction in detyrosinated alpha-tubulin levels, which impacts microtubule dynamics and neuronal differentiation. EpoY's inhibition of TCP is significant for research into neuronal differentiation defects and associated pathologies, including cancer and cardiomyopathies. -
Endogenous Metabolite
N-β-alanyldopamine hydrochloride is an endogenous metabolite that serves as a prominent dopamine derivative in the hemolymph. This compound plays a significant role in biochemical pathways and is critical for research on neurobiology and metabolic processes. Its biological activity provides insights into neurotransmitter function and regulation, making it a valuable tool for studying dopamine-related mechanisms in various biological systems. -
Endogenous Metabolite
H-Phe-Trp-OH, or Phenylalanyltryptophan, is an endogenous metabolite that plays a role in various physiological processes. It has been implicated in studies related to hepatocellular carcinoma and tic disorders, providing insights into their underlying mechanisms. This compound can be utilized in the exploration of metabolic pathways and biochemical interactions relevant to these conditions. -
Endogenous Metabolite
5a-Pregnane-3,20-dione is an endogenous metabolite of progesterone. It is involved in various biological pathways, including regulation of reproductive functions and modulation of the central nervous system. This compound serves as a valuable research tool in studying hormone metabolism and its effects on physiological processes. -
Endogenous Metabolite
2,6-Dimethylhydroquinone is an important endogenous metabolite produced by Mycobacterium strain DM1 during the catabolic process of 2,6-dimethylphenol (2,6-xylenol) degradation. This compound functions as a crucial metabolic intermediary and can be utilized as an indicator for early dysfunctions in biological treatment systems, aiding in the assessment of microbial activity and system efficiency in environmental and biotechnological research applications. -
Endogenous Metabolite
L-Thyronine is a deiodinated form of thyroxine, primarily targeting the thyroid hormone receptor. It plays a critical role in regulating metabolic processes and is involved in cellular growth and differentiation. This compound is utilized in research focusing on thyroid function, metabolism, and related endocrine disorders. -
Endogenous Metabolite
2-(4-Methoxyphenyl)acetic acid is an endogenous metabolite recognized for its role as a biomarker in the diagnosis of non-small cell lung cancer (NSCLC). This compound exhibits high sensitivity and specificity, making it instrumental for differentiating NSCLC patients from healthy controls. Its application in research can facilitate the understanding of metabolic changes associated with cancer development and progression. -
Endogenous Metabolite
DL-Kynurenine is an endogenous metabolite in the tryptophan metabolic pathway that can effectively cross the blood-brain barrier. It demonstrates a bidirectional regulatory effect on neural excitability and can exacerbate the convulsive and lethal effects of strychnine. As a precursor to Kynurenic acid, which antagonizes the glycine site of NMDA receptors, DL-Kynurenine serves as a valuable tool for research into neurotoxicity and excitatory neurotransmitter modulation. -
Endogenous Metabolite
Ac-Ala-OH is an endogenous metabolite that acts as an inhibitor of aminopeptidase prominent in various biological processes. This compound has been demonstrated to inhibit the activity of APEH, making it a valuable tool in the field of cancer research, particularly in studies related to breast cancer. Its role in modulating peptide metabolism offers potential insights into cancer biology and therapeutic strategies. -
Endogenous Metabolite
4-Methylpentanoic acid, also known as Isocaproic Acid, is a short-chain fatty acid that functions as an endogenous metabolite. It is a metabolite of 20 α-hydroxycholesterol and is detectable in fecal samples. The concentration of 4-Methylpentanoic acid has been associated with various health conditions, including depression. This compound is also valuable in studies focused on cholesterol metabolism and its implications in human health. -
Endogenous Metabolite
Pristanic acid is an endogenous metabolite primarily involved in the metabolism of branched-chain fatty acids. It serves as a key biomarker for Alpha Methylacyl CoA Racemase Deficiency and Zellweger Syndrome, facilitating research into these metabolic disorders. The study of pristanic acid can enhance the understanding of peroxisomal functions and related pathologies. -
Endogenous Metabolite
3-Methyl-2-cyclopenten-1-one is an endogenous metabolite that plays a significant role in various metabolic pathways. This compound exhibits biological activity relevant to cellular signaling and can serve as a valuable tool in studies of metabolic regulation and homeostasis. Its applications include investigating the metabolic profiles of different biological systems and exploring its potential effects on signaling pathways associated with cellular functions. -
Endogenous Metabolite
5,6-Dihydro-5-methyluracil, also known as Dihydrothymine, is an endogenous metabolite derived from the breakdown of thymine in both animal and plant sources. It serves as a key intermediate in pyrimidine metabolism and has implications in nucleic acid synthesis and degradation. While typically benign, elevated levels of 5,6-Dihydro-5-methyluracil may exhibit cytotoxic effects, making it significant in studies related to metabolic disorders and toxicity assessment. -
Endogenous Metabolite
Trans-Anethole is a phenylpropene derivative functioning as an endogenous metabolite with estrogenic properties at low concentrations and cytotoxic effects at higher concentrations in various tumor cell lines. This compound exhibits notable biological activities, including anti-aflatoxin, anti-thrombotic, and anti-diabetic effects. Additionally, Trans-Anethole contributes significantly to the characteristic aroma of plants such as fennel, myrtle, liquorice, and camphor, making it relevant for both therapeutic and aromatic research applications. -
Endogenous Metabolite
Isocorydine is an endogenous metabolite derived from Dicranostigma leptopodum. It exhibits synergistic effects when used in combination with Doxorubicin (DOX), showing promising potential for the treatment of hepatocellular carcinoma (HCC). This compound can be utilized in research applications focused on cancer therapeutics and metabolic pathways associated with tumor progression. -
Endogenous Metabolite
1,4-Dimethoxybenzene acts as an endogenous metabolite with notable biological activity. It displays anti-anxiety effects in experimental models, leading to increased atherogenic index levels in rabbits and promoting sedentary behavior, which may have implications for lipid metabolism and cardiovascular health. Additionally, 1,4-Dimethoxybenzene has shown to be non-clastogenic in the in vivo micronucleus test, suggesting a low potential for genotoxicity. This compound is useful in research focused on neurobiology, lipid metabolism, and toxicology. -
Endogenous Metabolite
L-Homocystine, an oxidized form of L-homocysteine, serves as an endogenous metabolite with significant implications in cardiovascular research. It is recognized as a pro-thrombotic agent, an inhibitor of vasodilation, and a pro-inflammatory factor, all of which are critical in understanding the mechanisms underlying cardiovascular diseases. Additionally, L-homocystine is involved in inducing endoplasmic reticulum stress, making it a valuable tool for investigating cellular stress responses. -
Endogenous Metabolite
Mesitaldehyde is an endogenous metabolite involved in various biological processes. It plays a significant role in metabolic pathways and can be utilized in research focused on metabolism and biochemical analysis. Mesitaldehyde serves as a valuable tool for studying cellular functions and potential implications in metabolic disorders. -
Endogenous Metabolite
Cholesteryl behenate is a cholesterol ester that serves as an endogenous metabolite involved in lipid metabolism. It is linked to low-density lipoprotein (LDL) complexes, where it undergoes hydrolysis within lysosomes to release free cholesterol. This compound is essential for studying cholesterol homeostasis and lipid transport mechanisms, contributing to research on cardiovascular health and metabolic disorders. -
Endogenous Metabolite
Acetylvaline is an N-acetylated amino acid derivative that serves as an important endogenous metabolite. It is typically present in low concentrations in the urine of healthy individuals, but levels can become significantly elevated in patients with maple syrup urine disease (MSUD). This compound is utilized primarily for the diagnostic detection of MSUD, aiding in the identification and management of this metabolic disorder. -
Endogenous Metabolite
Carveol is an endogenous metabolite known for its role as a monoterpenoid. It exhibits various biological activities, including antimicrobial and antioxidant effects. Carveol has applications in research related to pharmacology, natural products, and metabolic studies, making it a valuable compound for investigations into plant-derived bioactive substances. -
Endogenous Metabolite; Behavior Modifier
Hexadecanal is a volatile long-chain aliphatic aldehyde that acts as an endogenous metabolite and behavior modifier. It is emitted from various human sources, including feces, skin, and breath, and engages the highly conserved OR37B receptor in mammals. This compound has been shown to modulate functional connectivity in brain areas associated with social appraisal and aggression, making it relevant for studies on startle responses and aggressive behavior. Additionally, Hexadecanal demonstrates significant deterrent effects against the ant species Lasius niger, indicating its potential utility in behavioral research. -
Endogenous Metabolite
Glycyl-L-leucine is a dipeptide that serves as a substrate for glycyl-leucine dipeptidase, an enzyme involved in peptide metabolism. This compound plays a role in regulating amino acid availability and has implications in studying metabolic pathways and protein digestion. It is particularly useful in research applications focusing on enzymatic activity and peptide processing. -
Endogenous Metabolite
14,15-Epoxyeicosatrienoic acid (14,15-EET) is an endogenous metabolite derived from arachidonic acid. It functions as a potent inhibitor of in vivo platelet aggregation and promotes astrocytic clearance of amyloid-beta, making it relevant for Alzheimer's Disease research. 14,15-EET serves as a valuable tool for investigating its role in neuroinflammatory processes and cardiovascular health. -
Endogenous Metabolite
Cyclic N-Acetyl-D-mannosamine (Cyclic ManNAc) is an endogenous metabolite involved in various metabolic pathways. It plays a crucial role in glycan biosynthesis and cellular signaling. This compound is of interest for research applications in glycobiology, immunology, and cell biology, particularly in studying glycan-mediated interactions and their physiological implications. -
Endogenous Metabolite
L-Aspartic acid sodium is an endogenous metabolite and amino acid that plays a crucial role in various metabolic processes. It is primarily utilized in the development of prodrugs aimed at delivering therapeutic agents to colon and cecal tissues. Additionally, L-Aspartic acid sodium serves as a valuable tool in research focused on inflammatory conditions. -
Endogenous Metabolite
2'-Deoxycytidine-5'-diphosphate trisodium (dCDP) is an endogenous metabolite that plays a critical role in nucleotide biosynthesis. It is involved in the regulation of cellular processes such as DNA synthesis and repair. This reagent is valuable for research applications focusing on nucleotide metabolism, signaling pathways, and the biochemical mechanisms underlying cell proliferation and differentiation. -
Endogenous Metabolite
(S)-Salsolinol is a dopamine-derived endogenous metabolite known for its role in the central nervous system. This compound has been implicated in neurochemical pathways related to addiction and neurodegenerative diseases. Its unique structure allows for research applications in studying dopamine metabolism and related neurological functions. -
Endogenous Metabolite
(Rac)-sn-Glycerol 3-phosphate serves as an a-site substrate analogue, disrupting typical enzymatic reactions by inhibiting the rate of reaction between indole and nucleophilic indole analogues with E(A-A) when bound to the a-site. This compound plays a crucial role in studying metabolic pathways involving glycerol metabolism and can be utilized in research focusing on enzyme kinetics and substrate competition. Its inhibitory effects make it valuable for investigating enzymatic mechanisms and developing therapeutic strategies targeting glycerol-related pathways. -
Endogenous Metabolite
FAPy-adenine is an oxidized form of the DNA base adenine, serving as an endogenous metabolite with significant implications in neurodegenerative research. Elevated levels of FAPy-adenine have been observed in the brains of individuals with Alzheimer's disease, highlighting its potential as a biomarker. This compound is relevant for studies focusing on oxidative stress, tumor biology, aging processes, and neurodegeneration. -
Endogenous Metabolite
1-Methylimidazoleacetic acid is an endogenous metabolite of histamine, primarily found in urine. It plays a significant role in research related to mastocytosis, providing insights into histamine metabolism and its implications in various biological processes. This compound is valuable for studies exploring the biochemical pathways of mast cells and related disorders. -
Endogenous Metabolite
Phytanic acid is an endogenous metabolite known to play a crucial role in lipid metabolism. Its study is relevant for understanding various metabolic disorders, including Zellweger Syndrome, Alpha Methylacyl CoA Racemase Deficiency, Rhizomelic Chondrodysplasia Punctata, and Infantile Refsum Disease. Researchers utilize phytanic acid to investigate its biological activity and contributions to these rare genetic conditions. -
Endogenous Metabolite
2-Stearoyl-sn-glycero-3-phosphocholine is an endogenous metabolite and a lysophospholipid featuring stearic acid at the sn-2 position. This compound has been identified in rabbit myocardium, suggesting potential roles in cardiac biology and signaling pathways. Its study may enhance understanding of lipid metabolism and phospholipid signaling in various biological processes. -
Endogenous Metabolite
LacK free acid is a lysine derivative targeting endogenous metabolites involved in lactate acylation processes. This compound serves as a valuable tool for investigating metabolic pathways and studying the regulatory role of lactate in cellular physiology. Its application in research can provide insights into metabolic disorders and the biochemical mechanisms underlying various diseases. -
Endogenous Metabolite
D-Leucine is an endogenous metabolite that acts as a potent anti-seizure agent. It effectively terminates seizure activity even after onset, making it a valuable compound for seizure research. Additionally, D-leucine demonstrates a significant reduction in long-term potentiation without affecting basal synaptic transmission in vitro, offering insights into its mechanism in synaptic plasticity and neurotransmission pathways. -
Endogenous Metabolite
H-Asn(glcnac-beta-D)-OH is an endogenous metabolite that primarily targets N-glycan metabolism. This compound is significant for research into the NGLY1-CDDG, serving as a valuable tool for understanding glycosylation disorders. Its presence in urine offers insights into metabolic pathways and potential diagnostic applications. -
Endogenous Metabolite
3-Hydroxysebacic acid is an endogenous metabolite that plays a role in various metabolic pathways. It is primarily utilized in research related to Medium Chain Acyl-CoA Dehydrogenase Deficiency, a condition linked to fatty acid oxidation disorders. The compound may aid in understanding metabolic dysregulation and the biochemical alterations associated with this deficiency. -
Endogenous Metabolite
(S)-3-Hydroxybutanoic acid targets metabolic pathways as an endogenous metabolite. It plays a role in energy metabolism, being synthesized in the liver from acetyl-CoA and serving as an alternative energy source for the brain during periods of low blood glucose. Additionally, this compound is associated with depression and may serve as a potential biomarker for this condition in research applications. -
Endogenous Metabolite
2,5-Dimethylpyrazine is an endogenous metabolite characterized by its role in the flavor profile of food systems, particularly in whey protein hydrolysates derived from trypsin or proteinase enzymes. This compound can be qualitatively analyzed using stable isotope dilution assays and is also produced through microbial fermentation by Bacillus subtilis. Furthermore, 2,5-Dimethylpyrazine can undergo oxidation to generate 5-methylpyrazine-2-carboxylic acid, an important intermediate in the synthesis of antilipolytic agents. Known for its distinctive roasted peanut flavor, this volatile compound has significant implications in food science and flavor research. -
Endogenous Metabolite
N1,N8-Diacetylspermidine hydrochloride is an endogenous metabolite that serves as a biomarker in cancer research. This compound is involved in polyamine metabolism and is found in human urine. It is particularly valuable as a prognostic indicator for monitoring cancer treatment outcomes and conducting follow-up examinations in patients. -
Endogenous Metabolite
(R)-pyrrolidine-2-carboxylic acid, also known as (+)-(R)-Proline, is an endogenous metabolite that plays a crucial role in amino acid metabolism. This compound exhibits significant renal and hepatotoxic effects in experimental models, making it valuable for research into amino acid metabolism and associated toxicity mechanisms. Its applications include investigations of metabolic pathways and the effects of amino acid dysregulation on cellular health. -
Endogenous Metabolite
4-Methoxycinnamic acid is an endogenous metabolite belonging to the class of phenylpropanoids. It exhibits biological activities including antioxidant and anti-inflammatory properties, making it a valuable compound in research focused on metabolic pathways and natural product chemistry. This compound is commonly studied for its role in plant defense mechanisms and its potential therapeutic applications in various diseases. -
Endogenous Metabolite
H-HoArg-OH is an endogenous metabolite that acts as a potent inhibitor of human bone and liver alkaline phosphatase. This compound is valuable for investigating the role of alkaline phosphatase in bone and liver metabolism, providing insights into various biological processes and diseases. Its inhibitory properties make it a useful tool for studying related enzymatic pathways in biochemical research. -
Endogenous Metabolite
18:0,18:1 PS sodium is a phospholipid that plays a crucial role in the structure and function of synaptic vesicles and cholesterol metabolism. It is commonly utilized in metabolic research to investigate lipid interactions and cellular signaling pathways. This compound serves as an important tool for studying synaptic transmission and the biochemical networks associated with lipid metabolism. -
Endogenous Metabolite
N-Oleoyl Taurine is an endogenous metabolite that acts as an amino-acyl endocannabinoid. It is known to activate transient receptor potential (TRP) channels, specifically TRPV1 and TRPV4, implicating its role in calcium signaling. This compound has been isolated from rat brain and presents potential applications in research studying the physiological effects of TRP channel modulation and its involvement in neurological functions. -
Endogenous Metabolites
Methyl acetylacetate is a chemical reagent that serves as a versatile building block in the synthesis of α-substituted acetoacetates and cyclic compounds, including pyrazole, pyrimidine, and coumarin derivatives. This compound is particularly valuable in pharmaceutical research and holds potential for investigating inflammatory diseases, contributing to the understanding of metabolic pathways and disease mechanisms. -
Endogenous Metabolite
N-Acetylmannosamine 6-phosphate sodium salt is an endogenous metabolite that serves as a key metabolic intermediate in the degradation of sialic acid (Neu5Ac) by Staphylococcus aureus. This compound diminishes the affinity of the transcriptional regulator NanR for DNA, thereby modulating the metabolic pathway associated with sialic acid. It is useful for studies examining sialic acid metabolism and its regulatory mechanisms in microbial organisms. -
Endogenous Metabolite
(S)-(+)-1,2-Propanediol is an endogenous metabolite known for its role in various metabolic pathways. It serves as an organic solvent and diluent in pharmaceutical formulations and is utilized as a chiral synthetic intermediate in organic chemistry. Additionally, (S)-(+)-1,2-Propanediol is a valuable substrate for enzyme research, facilitating studies on enzyme kinetics and activity.
