Fig. 1 · Structure
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Dapagliflozin-3-O-β-D-glucuronide
Cat. No.
A72592
CAS
1351438-75-9
Endogenous Metabolite
Dapagliflozin-3-O-β-D-glucuronide is an endogenous metabolite of Dapagliflozin, produced primarily by the enzyme uridine diphosphate glucuronosyltransferase-1A9 (UGT1A9) in the liver and kidney. This compound plays a crucial role in the pharmacokinetics of Dapagliflozin, a selective inhibitor of sodium-glucose co-transporter 2 (SGLT2), which is utilized for improving glycemic control in type 2 diabetes management. Its study is significant in understanding drug metabolism and therapeutic efficacy in diabetic conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1351438-75-9 |
| Applications | Endogenous Metabolite |
| Formula | C27H33ClO12 |
| Molecular Weight | 585.00 |
| Synonyms | BMS-801576 |
| SMILES | ClC1=C(CC2=CC=C(C=C2)OCC)C=C([C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O[C@]4([C@@H]([C@H]([C@@H]([C@H](O4)C(O)=O)O)O)O)[H])O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.