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$0.00 Biological Activity
Letaxaban, also known as TAK-442, is a potent, selective, and orally active factor Xa inhibitor, which is a tetrahydropyrimidin-2(1H)-one derivative. TAK-442 inhibited endogenous FXa activity in platelet-poor human [half-maximal inhibitory concentration (IC(50)): 53 nM, TAK-442] and rat (IC(50): 32 nM, TAK-442) plasma.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.83 mL | 104.17 mL | 208.34 mL |
| 0.5 mM | 4.17 mL | 20.83 mL | 41.67 mL |
| 1 mM | 2.08 mL | 10.42 mL | 20.83 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.17 mL |
*The above data is based on the productmolecular weight 479.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Chemical Properties
| Catalog Num | A12871 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 479.98 |
| Formula | C22H26ClN3O5S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 870262-90-1 |
| Synonyms | TAK 442; TAK442 |
| SMILES | C1CNC(=O)N(C1)C2CCN(CC2)C(=O)[[email protected]@H](CS(=O)(=O)C3=CC4=C(C=C3)C=C(C=C4)Cl)O |
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