Letaxaban (TAK-442)

Catalog No.: A12871

factor Xa inhibitor

Letaxaban (TAK-442)

Letaxaban (TAK-442) Chemical Structure

CAS NO. 870262-90-1

Letaxaban, also known as TAK-442, is a potent, selective, and orally active factor Xa inhibitor, which is a tetrahydropyrimidin-2(1H)-one derivative. TAK-442 inhibited endogenous FXa activity in platelet-poor human [half-maximal inhibitory concentration (IC(50)): 53 nM, TAK-442] and rat (IC(50): 32 nM, TAK-442) plasma.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
25 mg
$1,200.00
50 mg
$2,000.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Letaxaban, also known as TAK-442, is a potent, selective, and orally active factor Xa inhibitor, which is a tetrahydropyrimidin-2(1H)-one derivative. TAK-442 inhibited endogenous FXa activity in platelet-poor human [half-maximal inhibitory concentration (IC(50)): 53 nM, TAK-442] and rat (IC(50): 32 nM, TAK-442) plasma.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.83 mL 104.17 mL 208.34 mL
0.5 mM 4.17 mL 20.83 mL 41.67 mL
1 mM 2.08 mL 10.42 mL 20.83 mL
5 mM 0.42 mL 2.08 mL 4.17 mL

*The above data is based on the productmolecular weight 479.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A12871
Actions Inhibitor
M. Wt 479.98
Formula C22H26ClN3O5S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 870262-90-1
Synonyms TAK 442; TAK442
SMILES C1CNC(=O)N(C1)C2CCN(CC2)C(=O)[[email protected]@H](CS(=O)(=O)C3=CC4=C(C=C3)C=C(C=C4)Cl)O

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