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Probucol dithiobisphenol

HO-1 Inducer

Probucol dithiobisphenol (DTBP) is a potent inducer of heme oxygenase 1 (HO-1) with notable antioxidant properties. It effectively inhibits atherosclerotic lesions in the aorta of Apoe−/− mice and promotes re-endothelialization, thereby reducing restenosis in rabbit arterial injury models. This compound is orally active, making it a valuable reagent for investigating vascular health and potential therapeutic applications in cardiovascular diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inducer
CAS Number	6386-58-9
Applications	HO-1 Inducer
Formula	C₂₈H₄₂O₂S₂
Molecular Weight	474.76
Synonyms	DTBP
SMILES	CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SSC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.