ME-344 is an isoflavone that functions as an anti-cancer agent, primarily by inhibiting tubulin polymerization and increasing mitochondrial reactive oxygen species (ROS) generation. This compound effectively induces apoptosis through the activation of caspase-3 and inhibits heme oxygenase-1 (HO-1), affecting its mitochondrial translocation. ME-344 exhibits synergistic effects with Vinblastine in leukemia cells and displays significant anti-tumor activity against leukemia and lung tumors. It is a valuable reagent for research on lung cancer, acute myeloid leukemia, and HER2-negative breast cancer.
ME-344 is an isoflavone that functions as an anti-cancer agent, primarily by inhibiting tubulin polymerization and increasing mitochondrial reactive oxygen species (ROS) generation. This compound effectively induces apoptosis through the activation of caspase-3 and inhibits heme oxygenase-1 (HO-1), affecting its mitochondrial translocation. ME-344 exhibits synergistic effects with Vinblastine in leukemia cells and displays significant anti-tumor activity against leukemia and lung tumors. It is a valuable reagent for research on lung cancer, acute myeloid leukemia, and HER2-negative breast cancer.
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