Fig. 1 · Structure
Documents & Downloads
ME-344
Anti-cancer Agent
ME-344 is an isoflavone that functions as an anti-cancer agent, primarily by inhibiting tubulin polymerization and increasing mitochondrial reactive oxygen species (ROS) generation. This compound effectively induces apoptosis through the activation of caspase-3 and inhibits heme oxygenase-1 (HO-1), affecting its mitochondrial translocation. ME-344 exhibits synergistic effects with Vinblastine in leukemia cells and displays significant anti-tumor activity against leukemia and lung tumors. It is a valuable reagent for research on lung cancer, acute myeloid leukemia, and HER2-negative breast cancer.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1374524-68-1 |
| Applications | Anti-cancer Agent |
| Formula | C22H20O4 |
| Molecular Weight | 348.39 |
| SMILES | OC1=CC=C2[C@H](C3=CC=C(O)C=C3)[C@H](C4=CC=C(O)C=C4)COC2=C1C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.