Fig. 1 · Structure
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Leteprinim potassium
Neuroprotective Agent
Leteprinim potassium (AIT-082) is a purine analog that functions as a neuroprotective agent. This compound enhances cognitive function by promoting the production of brain-derived neurotrophic factor (BDNF) mRNA in response to spinal cord injuries, and nerve growth factor (NGF) mRNA in the basal forebrain. Additionally, Leteprinim potassium mitigates glutamate-induced toxicity in cultured hippocampal neurons and elevates the mRNA levels of heme oxygenase 1 and 2, contributing to cellular defense against reactive oxygen species. Its applications extend to research on neuroprotection and cognitive enhancement strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 192564-13-9 |
| Applications | Neuroprotective Agent |
| Formula | C15H12KN5O4 |
| Molecular Weight | 365.39 |
| Synonyms | AIT-082 |
| SMILES | O=C(C1=CC=C(C=C1)NC(CCN2C=NC3=C2N=CNC3=O)=O)O[K] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.