(3S,4R)-ME-344 is a selective inhibitor of mitochondrial heme oxygenase 1 (HO-1) that functions by binding to and modifying the structure of HO-1. This enantiomer promotes the translocation of HO-1 from the rough endoplasmic reticulum to the mitochondria specifically in drug-sensitive cell lines such as H460 and SHP-77. By decreasing mitochondrial ATP production and inducing reactive oxygen species (ROS), it disrupts redox homeostasis and mitochondrial function. With its notable antitumor activity, (3S,4R)-ME-344 is a valuable compound for research in cancer, including studies focused on breast cancer.
(3S,4R)-ME-344 is a selective inhibitor of mitochondrial heme oxygenase 1 (HO-1) that functions by binding to and modifying the structure of HO-1. This enantiomer promotes the translocation of HO-1 from the rough endoplasmic reticulum to the mitochondria specifically in drug-sensitive cell lines such as H460 and SHP-77. By decreasing mitochondrial ATP production and inducing reactive oxygen species (ROS), it disrupts redox homeostasis and mitochondrial function. With its notable antitumor activity, (3S,4R)-ME-344 is a valuable compound for research in cancer, including studies focused on breast cancer.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
