Click Chemistry

BP Fluor 647 Alkyne is a fluorescent dye characterized by its bright green fluorescence and optimal excitation with 633 and 650 nm Argon lasers. The alkyne moiety enables efficient reactions with azides through copper-catalyzed Click Chemistry. With its four sulfonate groups, this dye demonstrates excellent water solubility and reduced aggregation across a pH range of 4 to 10. BP Fluor 647 Alkyne is ideal for applications in protein and antibody labeling, as well as nucleic acid studies, allowing for high labeling density.

Tetra-sulfo-Cy7 DBCO is a highly fluorescent near-infrared dye designed for applications requiring low background noise and high sensitivity. This water-soluble, hydrophilic probe exhibits remarkable photostability and maintains consistent fluorescence across a pH range of 4 to 10, minimizing autofluorescence interference in biological samples. Tetra-sulfo-Cy7 DBCO is ideal for use in various imaging techniques, where its long-wavelength emission is optimized for detection by advanced imaging systems.

BP Fluor 488 Tetrazine is a bright green-fluorescent dye that serves as a highly effective probe for detecting TCO-tagged biopolymers. Its remarkable cycloaddition kinetics, reaching up to 30,000 M-1 s-1 with trans-cyclooctenes (TCO), make it the fastest reported for any bioorthogonal reaction. This compound is particularly valuable for applications requiring rapid reaction kinetics, such as in vivo cancer imaging and pre-targeted cell labeling studies.

BP Fluor 405 alkyne triTEA is a blue-fluorescent dye that serves as a versatile labeling reagent in multi-color applications, including flow cytometry and super-resolution microscopy techniques like STORM. It exhibits optimal excitation around the 407 nm spectral line of krypton lasers and the 408 nm violet laser diode. This dye participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC), yielding a stable triazole linker upon reaction with azides. Additionally, a copper-free alternative, BP Fluor 405 DBCO, is available for applications sensitive to copper presence.

ROX azide, 5-isomer is a red-emitting fluorescent dye known for its high brightness and fluorescence quantum yield. The presence of an azide group enables reactive conjugation with alkyne, BCN, and DBCO through Click Chemistry, resulting in a stable triazole linkage. This compound is widely utilized in cellular imaging and labeling applications, facilitating the study of biomolecular interactions and dynamics.

BP Fluor 430 DBCO is a fluorescent dye that reacts with azides through a copper-free click chemistry mechanism, resulting in stable triazole formations without the need for copper catalysts or elevated temperatures. This dye exhibits bright, photostable green fluorescence, with optimal excitation at 432 nm and an emission peak at 539 nm, remaining pH independent across a broad pH range. BP Fluor 430 DBCO is suitable for various labeling applications in bioimaging and bioconjugation, although it is not recommended for staining intracellular components of fixed and permeabilized cells due to potential high background fluorescence.

BP Fluor 405 Picolyl Azide is a fluorescent dye designed for enhanced detection in bioconjugation reactions, utilizing a copper-chelating motif to increase local Cu(I) concentrations. This innovative reagent significantly accelerates the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction rate while minimizing the required copper catalyst concentration by at least tenfold. The incorporation of the picolyl azide moiety allows for greater sensitivity in alkyne detection, making it particularly advantageous for applications involving low-abundance targets or those requiring amplified signal intensity. This makes BP Fluor 405 an essential tool for researchers focusing on advanced fluorescent labeling techniques.

4-Amino-2-hydroxybenzohydrazide functions as an asymmetric unit, featuring two crystallographically independent molecules, designated A and B. This compound is of interest in structural biology and crystallography, providing insights into molecular interactions and conformational dynamics. Its unique structural characteristics make it suitable for investigations into novel synthetic pathways and pharmacological applications in drug discovery.

Itaconate-alkyne is a bioorthogonal probe designed for quantitative and site-specific chemoproteomic profiling of itaconation in live cells. As a functional analogue of itaconate, it exhibits comparable anti-inflammatory effects while facilitating the labeling of itaconate's genuine biological targets. This reagent incorporates an alkyne group, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it a valuable tool for studying metabolic processes and inflammatory responses.

ICG-DBCO is a near-infrared fluorescent dye targeting biological imaging applications. Its fluorescence emits at 813 nm upon excitation at 789 nm, making it suitable for labeling cells, biomolecules, and particles. This compound is essential for various research applications, including in vivo imaging and fluorescence microscopy, allowing for enhanced visualization of biological processes.

Alexa Fluor 594 azide is a fluorescent dye modified with an azide group, functioning as a FRET acceptor. Its minimal direct absorption under 488 nm excitation ensures excellent photostability and compatibility with various donor dyes, making it suitable for single-molecule imaging applications using total internal reflection fluorescence microscopy (TIRFM). This reagent is particularly valuable for visualizing copper nanoparticle-catalyzed click reactions, facilitating detailed studies of reaction dynamics and mechanisms.

FAM DBCO, 6-isomer is a fluorescent dye that incorporates a terminal dibenzocyclooctyne (DBCO) group, allowing for copper-free Click Chemistry applications. This compound exhibits high reactivity due to its strained structure, facilitating the efficient formation of covalent bonds in bioconjugation reactions. FAM DBCO can be utilized in a variety of biological applications, including cell labeling, tracking, and imaging studies.

Tamra azide is a versatile, azide-terminated fluorescent dye utilized primarily in click chemistry applications. It participates in CuI-catalyzed cycloaddition reactions with alkyne-functionalized nanodiamonds, enabling stable conjugation. Once attached, Tamra azide acts as a fluorescent label, exhibiting characteristic luminescence when excited at a wavelength of 555 nm with emission at 580 nm. This compound is valuable for a variety of imaging and labeling applications in chemical biology and materials science.

FAM azide, 5-isomer is a fluorescent dye commonly used in Click Chemistry for bioconjugation applications. This compound facilitates the labeling of biomolecules with minimal cytotoxicity, enhancing the visualization of cellular structures and processes. Its high fluorescence intensity makes it suitable for various applications, including live-cell imaging, biomolecule tracking, and the development of fluorescent probes in research and diagnostic assays.

BP Fluor 488 DBCO is a fluorescent dye designed for use in copper-free Click Chemistry reactions, specifically targeting azide-containing biomolecules such as antibodies, proteins, and peptides. It exhibits strong fluorescent properties, with an excitation peak at 499 nm and an emission peak at 520 nm, making it suitable for applications in microscopy and flow cytometry. This dye is derived from a pure 5-sulfonated rhodamine molecule, ensuring consistent performance and minimizing lot-to-lot variability caused by isomer ratio differences.

APN-Azide (3-(4-Azidophenyl)propiolonitrile) serves as a fluorescent dye, enabling selective labeling of target molecules due to its distinctive chemical structure. This compound is instrumental for bioimaging applications and the creation of molecular probes aimed at investigating various biological processes within cellular environments. Its codon-active properties enhance its utility in detailed studies of cellular and molecular dynamics.

Cyanine 5.5 DBCO chloride is a versatile click chemistry reagent featuring a cycloalkyne moiety that enables efficient, copper-free bioconjugation. This compound serves as a linker for the Cyanine 5.5 fluorophore, providing excellent stability and fast reaction kinetics. With excitation and emission wavelengths of 680 nm and 715 nm, respectively, it is ideal for applications in fluorescent imaging and labeling of lipids and biomolecules in various biological research contexts.

Cyanine 7 DBCO chloride is a fluorescent lipid reagent featuring a dibenzocyclooctyne (DBCO) group that facilitates copper-free click chemistry. This compound exhibits superior biocompatibility, rapid reaction kinetics, and stability, with an excitation/emission wavelength of 745/785 nm. It is primarily utilized in biological research for fluorescent labeling and imaging applications, enabling detailed visualization of cellular structures and processes.

Cyanine 5 azide is a fluorescent dye featuring an azide functional group, primarily serving as a click chemistry reagent. This compound can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. With excitation and emission wavelengths of 633 nm and 670 nm, respectively, it is valuable for a range of biological applications, including labeling and imaging studies.

Cyanine 3 DBCO chloride is a fluorescent lipid labeling reagent that incorporates a cycloalkyne group for click chemistry applications. This compound features a DBCO moiety, facilitating copper-free biocompatible click reactions with rapid kinetics and excellent stability. With excitation and emission wavelengths of 550 nm and 570 nm respectively, it is ideal for labeling and visualizing biomolecules in various biological research applications, including tracking cellular processes and studying lipid interactions.

Cyanine 3.5 azide is a fluorescent dye featuring an azide functional group, making it suitable for click chemistry applications. It effectively participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds, as well as in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This versatile reagent exhibits excitation and emission maxima at 591 nm and 604 nm, respectively, and is ideal for labeling and imaging studies in chemical biology and biomolecular research.

(E)-2-Hexadecenal alkyne is a fluorescent dye that serves as a chemical probe to investigate the cellular targets of 2-trans-Hexadecenal. This compound covalently modifies a range of proteins within cells, making it an effective tool for studying diseases associated with lipid metabolism. Researchers can utilize this reagent to gain insights into protein interactions and signaling pathways influenced by lipid-derived compounds.

N'-Phenylacetohydrazide is a hydrazine-derived compound utilized primarily as a biochemical assay reagent. It selectively reacts with carbonyl groups, making it effective for the identification and quantification of aldehydes and ketones in various organic compounds. This versatile reagent is widely employed in organic chemistry for analytical purposes, facilitating research into carbonyl-containing substances.

BODIPY FL azide is a BDP fluorescent dye characterized by an azide group that enables Click Chemistry. This green fluorophore, belonging to the borodipyrromethane class, exhibits a high quantum yield in aqueous solutions and demonstrates excellent stability against photobleaching. It is particularly suitable for applications requiring FAM fluorescence measurements, making it an ideal tool for various biochemical assays and cellular imaging studies.

SM6.1-azide is a ligand specifically targeting the αvβ6 integrin, featuring an azide group. This reactive moiety enables click chemistry with small molecules, peptides, or siRNA that possess DBCO or alkyne functionalities, facilitating efficient pulmonary-targeted delivery. This compound is valuable for research applications focused on integrin interactions and targeted therapeutics in respiratory conditions.

L-Galactose-azide is an L-fucose analogue that demonstrates utility in glycosylation studies and carbohydrate chemistry. Its azide functional group allows for click chemistry applications, facilitating the development of glycosylated compounds. This reagent is particularly valuable in the field of glycobiology for probing interactions involving fucose-containing glycans.

Thiophosphoro alkyne dichloridate is a histidine coupling agent that functions as a thio-phosphonyl dichloride reagent. It enables selective covalent coupling with histidine residues, facilitating the development of protein function probes. This compound is particularly useful in studies related to protein phosphorylation and the exploration of histidine-based modifications in biological systems.

Docosahexaenoic acid alkyne is a derivative of docosahexaenoic acid (DHA) characterized by the presence of a terminal ω-alkyne functional group. This compound serves as a valuable tool for studying lipid metabolism and fatty acid signaling pathways in various biological systems. It can be utilized in click chemistry applications, enabling the labeling and visualization of DHA-containing molecules in cellular environments.

Buthiazide is a diuretic compound primarily targeting renal function to promote urine production. It is commonly utilized in research focused on hypertension and fluid regulation. This compound facilitates the study of electrolyte balance and its therapeutic implications in cardiovascular disorders.

Altizide is an orally active diuretic that primarily targets renal processes to promote increased urine output. It is effective in the management of edema and hypertension, making it a valuable tool in cardiovascular and renal research. Altizide can be employed in studies aimed at understanding fluid balance and electrolyte regulation.

DBCO-PEG2-OH is a functionalized polyethylene glycol (PEG) derivative designed for the selective labeling of azide-modified biomolecules through a click chemistry mechanism. This compound facilitates bioconjugation and is widely utilized in the development of drug carriers and in protein labeling applications. Its versatility makes it an important tool in biochemistry and chemical biology research.

BCN-CE-phosphoramidite is an oligonucleotide modifier featuring a BCN (strained cyclooctyne) structure, which enables bioorthogonal reactions. This reagent is designed for efficient bioconjugation in chemical biology applications. It is particularly useful for labeling oligonucleotides with diverse probes, facilitating studies in nucleic acid research and functional assays.

Nicotinohydrazide, also known as nicotinic acid hydrazide, is a small molecular compound that serves as a hydrazine derivative. This compound is of interest in various biological research applications due to its potential to act as a precursor in the synthesis of pharmacologically active agents. It may also play a role in the study of nicotinic receptor modulation and hydrazone formation in biochemical pathways. Further investigation into its mechanisms could provide insights into its utility in drug development and therapeutic research.

Psoralen-triethylene glycol azide is a chemical probe that targets RNA structure and conformation in living cells through selective crosslinking. This compound facilitates RNA analysis and characterization using advanced techniques such as RNA crosslinking followed by deep sequencing. Its applications extend to studies in RNA biology, enabling insights into RNA-protein interactions and RNA folding dynamics.

Polythiazide is a thiazide diuretic agent primarily targeting renal sodium reabsorption. It is known for its antihypertensive properties, effectively reducing blood pressure and alleviating edema. Additionally, Polythiazide exhibits phototoxicity, which may be relevant in certain research applications. Its use is common in studies related to hypertension and fluid balance regulation.

TCO-PEG5-C2-Mal is a heterobifunctional linker designed for use in tetrazine ligation and sulfhydryl conjugation. This reagent facilitates the efficient coupling of biomolecules by enabling selective labeling and conjugation strategies. It is particularly useful in bioconjugation applications, including targeted drug delivery and the development of novel therapeutics.

(Rac)-BCN-L-Lysine is a Click Amino Acid featuring a bicyclononyne (BCN) moiety that serves as a linker in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. This compound is designed for efficient bioconjugation through strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing partners. Its application in drug development facilitates targeted protein degradation research, advancing studies in pharmacology and chemical biology.

1,2,4,5-Tetrazine-3,6-dicarboxylic acid serves as a crucial building block for metal-organic frameworks (MOFs). This compound exhibits robust coordination properties, facilitating the formation of porous structures that can be utilized in gas storage, catalysis, and sensing applications. Its unique tetrazine moieties offer potential for enhanced stability and functionality in various chemical research endeavors.