Catalog No.
Product Name
Application
Product Information
Citations
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Cis Isomer of CITCO
Z-CITCO is the cis isomer of CITCO and acts as an agonist for the constitutive androstane receptor (CAR), with an EC50 value of 3.9 µM. This compound is significant in the study of hepatic gene expression and plays a role in drug metabolism research. Z-CITCO is also useful for investigating the modulation of xenobiotic metabolism and its implications in pharmacology and toxicology. - DBCO-NHS ester 2 is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 2 is a derivative of Dibenzylcyclooctyne (DBCO) used in copper-free click chemistry.
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Drug-Linker Conjugate for ADC
DBCO-HS-PEG2-VA-PABC-SG3199 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It features a SG3199-based DNA small channel crosslinker combined with a cleavable linker, facilitating targeted delivery of therapeutic agents. This reagent is suitable for the synthesis of ADCs, enabling enhanced efficacy in drug-based cancer therapies and other biomedical research applications. -
Phosphatase Marker
5-FAM-Alkyne is a selective fluorescent biosensor targeting alkaline phosphatase (ALP) activity. This compound incorporates an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its high sensitivity makes it a valuable tool for studying ALP-related biological processes and for applications in bioorthogonal labeling in chemical biology research. -
Drug-Linker Conjugate
TCO-PEG3-Glu-Val-Cit-PABC-MMAF is a drug-linker conjugate designed for targeted delivery in antibody-drug conjugate (ADC) applications. It incorporates a trans-cyclooctene (TCO) moiety for efficient click chemistry attachment, a polyethylene glycol (PEG) spacer for solubility enhancement, and a cleavable linker (Glu-Val-Cit) that releases the potent cytotoxic agent MMAF upon internalization. This reagent is ideal for advancing research in targeted cancer therapeutics and ADC development. -
Btk Inhibitor
(Rac)-Ibrutinib alkyne is a potent Bruton's tyrosine kinase (Btk) inhibitor with an IC50 of 0.72 nM. This compound effectively disrupts B-cell receptor signaling, demonstrated by an IC50 of 9 nM for inhibiting calcium flux in Ramos cells. (Rac)-Ibrutinib alkyne is suitable for investigating various Btk-related pathologies, including rheumatoid arthritis and other immune disorders. -
Click Chemistry Reagent
Tetrazine-Amine is a click chemistry reagent featuring a tetrazine functional group that enables covalent labeling of live cells via cycloaddition. This compound undergoes an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, facilitating bioorthogonal reactions in complex biological systems. Tetrazine-Amine is utilized in various research applications, including probes for imaging and tracking biomolecules, as well as in the development of drug delivery systems. -
Metal-organic Framework
1,4-Benzenedicarboxylic acid, 2,3-dihydroxy-, 1,4-dihydrazide, also known as 2,3-Dihydroxyterephthalohydrazide, serves as a key building block in the synthesis of metal-organic frameworks (MOFs). This compound exhibits significant potential in applications related to gas storage, catalysis, and separation technologies. Its dual functional groups enhance coordination with metal ions, thereby facilitating the formation of robust MOF structures suitable for various research applications in material science and chemistry. -
Metal-organic Framework
4,4'-(1,2,4,5-Tetrazine-3,6-diyl)dibenzoic acid serves as a key building block for the synthesis of metal-organic frameworks (MOFs). Its unique structural features facilitate rigorous coordination with metal ions, enhancing the stability and functionality of the resulting frameworks. This compound is invaluable in studies focusing on gas storage, separation processes, and catalysis applications within the field of materials science. -
Stable Isotope
Acetohydrazide-d3 is a deuterium-labeled derivative of Acetohydrazide, functioning as a stable isotope. This compound is utilized in organic synthesis and can undergo catalytic hydrogenation to yield N′-methyl acethydrazide (MAH). It serves as a valuable tool for researchers studying reaction mechanisms and developing novel chemical pathways in organic chemistry. -
Metal-organic Framework
3,6-Di(pyridin-2-yl)-1,2,4,5-tetrazine targets metal-organic frameworks (MOFs) and serves as a versatile building block in their construction. This compound exhibits significant potential for enhancing the structural stability and surface area of MOFs, making it valuable for applications in gas storage, catalysis, and sensing. Its unique chemical properties facilitate the design of innovative materials for advanced technological applications in the fields of energy and environmental science. -
Metal-organic Framework
3,6-Di(pyridin-4-yl)-1,2,4,5-tetrazine serves as a scaffold for the design of metal-organic frameworks (MOFs). This compound exhibits significant coordination properties due to its multi-dentate nature, facilitating the formation of stable MOFs with potential applications in gas storage, catalysis, and sensing. Its unique structural features make it a valuable tool for researchers exploring advanced materials in inorganic chemistry. -
Metal-organic Framework
3,6-Di(pyridin-3-yl)-1,2,4,5-tetrazine is a metal-organic framework (MOF) known for its exceptional ligand properties. It exhibits significant interactions with metal ions, facilitating the formation of stable and structured frameworks. This compound is widely utilized in research applications aimed at developing advanced materials for gas storage, catalysis, and sensing technologies. Its unique structure makes it a valuable tool for exploring metal coordination and enhancing material functionalities. -
Stable Isotope
Chlorothiazide-13C,15N2 is the stable isotope-labeled form of Chlorothiazide, incorporating 13C and 15N isotopes. Chlorothiazide functions as an orally active diuretic and anti-hypertensive agent, primarily targeting renal sodium-coupled transport processes. This reagent is beneficial for research applications involving metabolic studies, pharmacokinetic assessments, and isotopic tracing in physiological experiments. -
Biochemical Assay Reagent
Methyltetrazine-PEG2-DBCO is a water-soluble reagent designed for efficient bioconjugation through the copper-free Click Chemistry mechanism. Featuring a DBCO moiety linked by a PEG spacer, this compound facilitates the conversion of azido-tagged peptides or proteins into tetrazine-functionalized derivatives without the need for catalysts or auxiliary reagents. Its key biological activity enhances the versatility of biochemical assays and is particularly valuable in the fields of proteomics and materials science. -
Biochemical Assay Reagent
3-Maleimidylpropanoyl hydrazide hydrochloride is a biochemical assay reagent that primarily functions as a crosslinking agent. It facilitates the formation of stable conjugates between thiol-containing biomolecules, making it valuable for labeling and detecting proteins in various assays. This reagent is widely used in life sciences research for studying protein interactions and developing bioconjugates for drug delivery applications. -
Biochemical Assay Reagent
Methyltetrazine-amido-PEG8-amine Trifluoroacetate is a heterobifunctional linker designed for biochemical assays. It features a terminal methyltetrazine that enables efficient reactions with TCO-containing compounds without the need for copper catalysis or elevated temperatures. The terminal amine facilitates specific reactions with NHS esters, while the PEG spacer improves water solubility, enhancing overall reagent performance in various research applications. -
Biochemical Assay Reagent
Bromoacetamido-PEG2-azide is a heterobifunctional polyethylene glycol (PEG) linker that features a reactive bromoacetamido group and a terminal azide moiety. The bromoacetamido component facilitates nucleophilic substitution, enabling covalent attachment to various nucleophiles. The azide group is compatible with alkyne, BCN, and DBCO through Click Chemistry, making this reagent an essential tool for biochemical assays and bioconjugation applications in chemical biology and drug development. -
Biochemical Assay Reagent
m-PEG2-DBCO is a monodisperse polyethylene glycol (PEG) reagent that facilitates copper-free click chemistry. It enables the efficient reaction between dibenzocyclooctyne (DBCO) and azide-containing compounds, making it a valuable tool for bioconjugation applications. This reagent is particularly useful in biochemical assays and labeling techniques where selective and efficient conjugation is required. -
Biochemical Assay Reagent
BP Fluor 546 DBCO is an azide-reactive probe designed for imaging azide-tagged biomolecules through a copper-free click reaction. This reagent offers a stable triazole formation without the need for copper catalysts or elevated temperatures, making it suitable for applications sensitive to copper. The water-soluble, orange-fluorescent dye exhibits absorption and emission maxima at 554 nm and 570 nm, respectively, and is compatible with 488 nm and 532 nm laser lines. BP Fluor 546 DBCO can be conjugated to various biomolecules, including antibodies, peptides, and proteins, facilitating reliable signal generation in imaging and flow cytometry. -
Crosslinker
endo-BCN-PEG4-amine is a versatile crosslinker reagent that utilizes the BCN (Bicyclo[6.1.0]nonyne) moiety, enabling efficient click chemistry reactions with azide-tagged molecules. The attached amine group exhibits reactivity towards carboxylic acids, activated NHS esters, and carbonyls, including ketones and aldehydes. This compound is ideal for applications in bioconjugation, surface modification, and the synthesis of complex biomolecular architectures, facilitating the study of protein interactions, drug delivery systems, and other research applications in chemical biology. -
Metal-organic Framework
2,2'-((1,2,4,5-Tetrazine-3,6-diyl)bis(sulfanediyl))diacetic acid serves as a ligand for metal-organic frameworks (MOFs). This compound is characterized by its ability to stabilize metal ions, enhancing the structural integrity of the framework. It is utilized in research applications involving gas adsorption, catalysis, and sensor development due to its promising electronic and chemical properties. -
Metal-organic Framework
3,6-Di(pyridin-2-yl)-1,4-dihydro-1,2,4,5-tetrazine is a compound with significant potential as a building block for metal-organic frameworks (MOFs). It exhibits unique structural properties that facilitate the coordination of metal ions, enabling the formation of stable and functionalized MOFs. This compound is suitable for research applications in gas storage, catalysis, and drug delivery systems, contributing to advancements in material science and nanotechnology. -
Trinitride
(Rac)-Azide-deoxy-ascomycin-O-ethylene is a nitrogen-containing derivative of the macrolide immunosuppressant ascomycin. It functions as a trinitride, exhibiting potential biological activity related to immunosuppression. This compound is primarily utilized in pharmacological research, particularly in the study of immunological responses and the development of novel therapeutic agents targeting immune-related conditions. -
Drug Intermediate
Cyanoacetohydrazide serves as a pharmaceutical intermediate, primarily utilized in the synthesis of acylhydrazide hydrazone derivatives. These derivatives have demonstrated notable antibacterial and anti-tumor activities, making cyanoacetohydrazide a valuable compound in drug development and medicinal chemistry research. Its versatile applications in synthesizing bioactive compounds contribute significantly to advancing therapeutic strategies. -
Drug Intermediate
DFO-BCN is a chemical intermediate utilized in the synthesis of the PET/CT imaging agent DFO-CPC634 via click chemistry. This compound serves as a valuable tool in radiopharmaceutical development, enabling effective labeling and visualization in molecular imaging studies. Its role as a precursor enhances the efficiency of tracer synthesis, supporting research in diagnostic imaging applications. -
Drug Intermediate
2-Pyridinecarbohydrazide is a versatile building block commonly employed as a drug intermediate in synthetic processes. Its structure allows for diverse modifications, facilitating the development of biologically active compounds. Applications include the synthesis of pharmaceuticals and agrochemicals, making it an essential reagent in chemical research and development. -
Synthetic Intermediate
Nicotinoyl azide serves as a versatile synthetic intermediate, notable for its ability to form high-energy intermediates that generate C-8 adducts with adenosine and guanosine. The compound contains an azide functional group and is amenable to copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in ring strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds featuring DBCO or BCN functionalities, making it valuable for diverse applications in chemical biology and medicinal chemistry. -
Biochemical Assay Reagent
Methyltetrazine-amido-bis-(carboxyethoxymethyl)-methane is a versatile click chemistry reagent designed for biochemical assays, featuring three carboxylic acid groups and a methyltetrazine moiety. It facilitates the formation of stable covalent bonds with TCO-containing compounds through a highly selective inverse-electron demand Diels-Alder cycloaddition reaction, eliminating the need for catalysis or elevated temperatures. Additionally, the terminal carboxylic acid can efficiently couple with primary amines in the presence of activators such as EDC or HATU, forming stable amide bonds for a variety of bioconjugation applications in chemical and biological research. -
Biochemical Assay Reagents
β-GalNAc-PEG4-Azide is a specific ligand for the asialoglycoprotein receptor, linked via a PEG4 spacer and featuring an azide functionality. This compound enables efficient click chemistry applications, facilitating conjugation with various biomolecules for biochemical assays. Its design enhances targeted delivery and is particularly useful in the study of glycoprotein interactions and receptor-mediated endocytosis. -
Biochemical Assay Reagent
Tetra-(amido-PEG10-azide) is a branched polyethylene glycol (PEG) reagent featuring four azide groups at its termini, facilitating PEGylation through Click Chemistry. Its unique structure enhances solubility and stability of biomolecules, making it ideal for biochemical assays and labeling applications. The incorporation of this reagent can significantly improve the pharmacokinetics and bioavailability of therapeutic proteins and peptides in research settings. -
Biochemical Assay Reagent
Octyl azide (1-Azidooctane) is a biochemical assay reagent characterized by an azide functional group and an eight-carbon alkyl chain. The azide group is capable of undergoing Click Chemistry reactions with alkynes, BCN, and DBCO, facilitating the formation of stable triazole linkages. This compound serves as a valuable tool in bioconjugation applications, enabling precise labeling and functionalization in various biochemical studies. -
Biochemical Assay Reagent
N-(acid-PEG10)-N-bis(PEG10-azide) is a versatile PEG reagent featuring a terminal carboxylic acid and dual azide groups. The hydrophilic PEG spacer enhances solubility in aqueous environments, facilitating its use in biochemical assays. Through Click Chemistry, the azide groups can efficiently react with alkynes, BCN, and DBCO to form stable triazole linkages. Additionally, the terminal carboxylic acid can conjugate with primary amines in the presence of coupling agents such as EDC or HATU to create stable amide bonds, making it suitable for various bioconjugation applications. -
Biochemical Assay Reagent
Methyltetrazine-PEG4-DBCO is a versatile biochemical assay reagent featuring a PEG linker, a terminal TCO reactive moiety, and a DBCO group. The DBCO component facilitates copper-free Click Chemistry reactions, enabling efficient bioconjugation. This reagent is ideal for converting azido-containing peptides or proteins into tetrazine-modified counterparts without the need for catalysts or auxiliary reagents, making it a valuable tool for researchers in biochemistry and protein engineering. -
PEG Linker
Azido-PEG8-hydrazide-Boc is a PEG linker featuring an azide moiety and a Boc-protected hydrazide. This compound serves as a versatile reagent for click chemistry applications, specifically undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. It is ideal for bioconjugation, enabling the formation of stable conjugates in various biological research applications. -
Biochemical Assay Reagent
Iodoacetamido-PEG6-azide is a biochemical assay reagent featuring a hydrophilic PEG linker with an azide group and a terminal iodoacetamido moiety. The azide moiety can undergo click chemistry reactions with alkynes, BCN, or DBCO to form stable triazole linkages. The iodoacetamido group facilitates covalent binding to thiol groups in cysteine residues, effectively preventing the formation of disulfide bonds in proteins. This compound is ideal for applications in protein labeling, modification, and tracking in biochemical studies. -
Biochemical Assay Reagent
endo-BCN-PEG4-Boc-amine is a PEG-based linker incorporating a bicyclononyne (BCN) group and a Boc-protected amine. This unique structure enables the BCN group to react selectively with azide-tagged biomolecules, facilitating bioconjugation applications. The Boc-protected amine can be deprotected under mild acidic conditions, allowing for further functionalization in biochemical assays and research involving peptide or protein modifications. -
Biochemical Assay Reagent
AZD-PEG2-azide is a biochemical assay reagent featuring an azide functional group appropriate for bioconjugation applications. Its primary mechanism involves reacting with alkyne-containing partners through the click chemistry reaction, facilitating the creation of stable linkages. This reagent is ideal for various life science research applications, including the development of drug delivery systems and probing biological interactions. -
Biochemical Assay Reagent
Azide-PEG8-Tos is a PEG-based linker characterized by the presence of an azide and a tosylate group. The tosylate functions as an effective leaving group, facilitating displacement reactions with nucleophiles, while the azide serves as a component for click chemistry, allowing for selective reactions with terminal alkynes or strained cyclooctynes. This reagent is valuable in biochemical assays and applications requiring precise bioconjugation techniques. -
Biochemical Assay Reagent
Azido-PEG19-azide is a versatile click chemistry reagent characterized by two terminal azide groups. It facilitates efficient conjugation with alkynes, BCN, and DBCO through azide-alkyne cycloaddition reactions. This reagent is widely utilized in biochemical assays and polymer synthesis, enabling the labeling and modification of biomolecules for various research applications. -
Biochemical Assay Reagent
(Acid-PEG10)-Tri-(Azide-PEG10-ethoxymethyl)-methane is a versatile biochemical assay reagent that facilitates Click Chemistry reactions with propargyl, BCN, or DBCO reagents. The carboxylic acid group exhibits reactivity towards primary amino groups when coupled with EDC or HATU, enabling efficient bioconjugation. This reagent is ideal for applications in developing bioconjugates, analyzing protein interactions, and enhancing labeling strategies in biochemical assays. -
Biochemical Assay Reagent
DBCO-N-bis(PEG4-acid) is a branched click chemistry reagent featuring a DBCO group that facilitates copper-free Click Chemistry reactions. Its carboxylic acid functionalities enable efficient coupling with primary amines, utilizing activators such as EDC or HATU to form stable amide bonds. This reagent is ideal for biochemical assays and applications requiring bioconjugation, contributing to the development of diverse biomolecular constructs. -
Biochemical Assay Reagent
t-Boc-aminooxy-pentane-azide is a versatile linker designed for biochemical assays, featuring an azide group and a Boc-protected amino group. The azide moiety enables selective reactions with alkynes, BCN, and DBCO through Click Chemistry, facilitating the formation of stable triazole linkages. Upon mild acidic deprotection, the Boc group is removed, yielding a free amine for further applications in bioconjugation and peptide synthesis. This compound is ideal for use in various chemical biology studies and assay development. -
Biochemical Assay Reagent
4-Azide-TFP-Amide-SS-Sulfo-NHS is a biochemical assay reagent featuring an aryl azide, a cleavable disulfide bond, and an NHS ester. The aryl azide facilitates photo-activation using UV light (250 to 350 nm) for efficient conjugation with biomolecules, while the NHS ester enables targeted coupling with amines. The inclusion of a stabilizing fluorine within the structure aids in the stabilization of the free radical intermediate, and the disulfide bond can be cleaved under reducing conditions, providing versatility in biochemical applications. -
Biochemical Assay Reagent
C18-PEG4-Azide is a hybrid linker that combines a hydrophobic C18 fatty acid chain with a hydrophilic PEG4 spacer and an azide functional group. The azide moiety engages in efficient click chemistry with terminal alkynes or strained cyclooctynes, such as DBCO or BCN. This compound is essential for applications in biochemical assays, facilitating the conjugation of biomolecules and the development of complex molecular probes for various research applications. -
Biochemical Assay Reagent
Mal-amido-PEG5-alkyne functions as a biochemical assay reagent featuring a maleimide group and an alkyne component. This PEG-based linker enhances solubility in aqueous environments while enabling versatile coupling reactions. The alkyne moiety can engage in copper-catalyzed azide-alkyne Click Chemistry, resulting in a stable triazole bond with azide-containing biomolecules. Additionally, the maleimide group facilitates covalent attachment to thiol-containing compounds, making it ideal for applications in bioconjugation and protein labeling studies. -
Biochemical Assay Reagent
Biotinamide-C3-PEG3-C-alkyne is a biotin-conjugated polyethylene glycol (PEG) reagent featuring a terminal alkyne. This compound facilitates efficient coupling through Click Chemistry with various azide-containing molecules, such as BCN and DBCO. It is primarily utilized in biochemical assays for labeling and detecting biomolecules, enhancing the study of biological processes and interactions. -
Biochemical Assay Reagents
2,3,4,6-Tetra-O-acetyl-β-D-mannopyranosyl azide is a chemical compound that serves as a valuable reagent in biochemical assays within glycobiology research. It functions as a glycosyl donor, facilitating the exploration of carbohydrate-protein interactions and the synthesis of oligosaccharides. This compound aids in the development of glycomimetics and other glycan-based applications, contributing to advancements in carbohydrate chemistry and glycan biology. -
Biochemical Assay Reagent
Tri(Azide-PEG10-NHCO-ethyloxyethyl)amine is a branched polyethylene glycol (PEG) linker featuring three terminal azide moieties. This compound facilitates PEGylation through efficient Click Chemistry, making it valuable for various biochemical assay applications. Its unique structure enhances solubility and biocompatibility, supporting the development of diverse bioconjugates in chemical biology and drug formulation studies.
