Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Trityl-PEG8-azide is a PEG-based linker specifically designed for PROTAC synthesis, facilitating targeted protein degradation. This compound features an azide group, enabling its use in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-functionalized molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool in chemical biology and drug development research. -
PROTAC Linker
endo-BCN-PEG4-Boc is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, thereby improving their pharmacokinetic properties. It is essential for research applications involving targeted protein degradation, allowing for the selective modulation of protein levels within cells. -
PROTAC Linker
Benzyl-PEG6-azide is a polyethylene glycol (PEG)-based reagent designed as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group which enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclo[6.1.0]non-4-yne (BCN) derivatives, making it a versatile tool in chemical biology for targeted protein degradation studies. -
PROTAC linker
N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 functions as a PEG-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound is equipped with an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool for chemical biology applications in targeted protein degradation research. -
PROTAC Linker
m-PEG3-Sulfone-PEG3-azide is a PEG-based linker specifically designed for PROTAC synthesis. Featuring an azide functional group, this compound enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, facilitating the development of innovative targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
TCO-amine is an alkyl chain-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). As a click chemistry reagent, TCO-amine features a TCO group that participates in inverse electron demand Diels-Alder (iEDDA) reactions with Tetrazine-containing molecules. This allows for precise conjugation in the development of targeted protein degradation strategies, facilitating studies in cellular biology and therapeutic applications. -
PROTAC Linker
m-PEG4-Hydrazide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its unique hydrazide functionality facilitates the conjugation of target proteins with E3 ubiquitin ligases, thereby promoting targeted protein degradation. This compound is an essential tool for researchers exploring targeted therapy and studying protein regulation mechanisms. -
PROTAC Linkers
DBCO-NH-(CH2)4COOH is a Proximity-Activated Linker (PROTAC) that facilitates targeted protein degradation by linking target proteins to E3 ligases. This compound features a DBCO functional group, which enables efficient reaction through strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its use in PROTAC synthesis supports research in protein modulation and therapeutic development, providing a versatile tool for advancing insights in cellular biology and drug discovery. -
PROTAC linker
N-(m-PEG4)-N'-(azide-PEG4)-Cy3 is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This molecule features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalities. Its efficient coupling capabilities make it valuable for advancing research in targeted protein degradation and the development of therapeutic modalities. -
PROTAC Linkers
TCO-C3-PEG3-C3-amine is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of PROTACs by enhancing their solubility and stability. It plays a crucial role in targeted protein degradation research, allowing researchers to explore novel therapeutic strategies in various disease models. -
PROTAC Linkers
Boc-NH-PEG4-azide is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of PROTACs. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Boc-NH-PEG4-azide can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with donors like DBCO or BCN. Its versatile reactivity makes it a valuable tool in chemical biology and drug discovery research applications. -
PROTAC Linkers
N-(Boc-PEG3)-N-bis(PEG3-azide) serves as a polyethylene glycol (PEG)-based linker for PROTAC (proteolysis targeting chimeras) synthesis, facilitating the development of targeted protein degradation strategies. This compound contains an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with alkyne-containing partners, such as DBCO and BCN groups. Its versatile reactivity makes it valuable in chemical biology research for constructing novel PROTACs. -
PROTAC linker
TCO-PEG5-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a TCO group, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules. Its versatile functionality makes TCO-PEG5-NHS ester a valuable tool for developing targeted protein degradation strategies in cellular studies. -
PROTAC Linkers
m-PEG16-azide is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing compounds. Additionally, m-PEG16-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) tagged molecules, making it a valuable tool for bioconjugation and targeted protein degradation studies. Its versatile reactivity enhances the development of novel therapeutic strategies in chemical biology and drug discovery. -
PROTAC linker
m-PEG5-azide is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing molecules. This versatile reagent is essential for advancing research in targeted protein degradation and related fields. -
PROTAC Linkers
TCO-PEG4-TCO is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound plays a crucial role in facilitating the targeted degradation of specific proteins, enabling the development of novel therapeutic strategies. Its application in research underscores its importance in the fields of protein modulation and targeted therapy. -
SFRP1 Inhibitor
BCN512 is an inhibitor of Secreted Frizzled-Related Protein 1 (SFRP1). This compound plays a significant role in attenuating tissue fibrosis and is valuable for studying the mechanisms underlying inflammatory diseases. BCN512 provides a useful tool for researchers investigating therapeutic strategies targeting fibrotic pathways. -
Cis Isomer of CITCO
Z-CITCO is the cis isomer of CITCO and acts as an agonist for the constitutive androstane receptor (CAR), with an EC50 value of 3.9 µM. This compound is significant in the study of hepatic gene expression and plays a role in drug metabolism research. Z-CITCO is also useful for investigating the modulation of xenobiotic metabolism and its implications in pharmacology and toxicology. -
Non-natural Amino Acid
(Rac)-Azide-phenylalanine is a non-natural amino acid featuring an azide functional group, allowing for selective incorporation into proteins for labeling purposes. This compound serves as a valuable tool in click chemistry, participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. Its applications extend to bioconjugation strategies, facilitating the study of protein interactions and dynamics in chemical biology and biochemical research. -
Endogenous Protein Marker
N-TCO-L-lysine is a non-canonical amino acid featuring a trans-cyclooctene (TCO) bioorthogonal reactive linker. This compound is engineered for the selective labeling of endogenous proteins through a bioorthogonal click reaction with SiR-Tz, facilitating site-specific incorporation. N-TCO-L-lysine is valuable for super-resolution and live-cell imaging applications, enabling researchers to study the dynamics and localization of proteins in their native environments. -
Click Chemical Reagent
Biotin-azide (N-(3-Azidopropyl)biotinamide) serves as a versatile click chemical reagent featuring a terminal azide moiety. This compound facilitates the synthesis of biotinylated conjugates through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Biotin-azide is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclo[6.1.0]nonyne (BCN) functional groups. Its applications span various fields, including bioconjugation and visualization studies in chemical biology. -
APEX2 Probe
Alkyne-phenol is a clickable probe specifically designed for use with ascorbate peroxidase 2 (APEX2). This reagent significantly enhances APEX-labeling efficiency in intact yeast cells due to its improved permeability through cell walls compared to traditional APEX2 substrates. Alkyne-phenol aids in the identification of APEX-labeling sites, providing clear insights into the membrane topology of mitochondrial proteins. Additionally, it features an alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a versatile tool for click chemistry applications in biological research. -
Click Chemistry Reagent
DBCO-amine is a click chemistry reagent featuring a dibenzocyclooctyne (DBCO) group, which facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound is instrumental in the synthesis of antibody-drug conjugates (ADCs), providing a targeted approach for delivering therapeutics. Its utility extends to various applications in chemical biology, including bioconjugation and the development of precision medicine strategies. -
Click Chemistry Reagent
DBCO-acid is a click chemistry reagent that features a DBCO (dibenzocyclooctyne) moiety, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is essential for the synthesis of antibody-drug conjugate (ADC) linkers, such as DBCO-NHS ester and DBCO-PEG-MMAE. DBCO-acid facilitates the formation of agent-linker conjugates, providing researchers with robust tools for bioconjugation applications in drug delivery and molecular labeling. -
Biotinylation Reagent
DBCO-PEG4-Biotin is an azadibenzocyclooctyne-biotin conjugate designed for biotinylation applications. This reagent facilitates the introduction of a biotin moiety to azide-tagged biomolecules through copper-free strain-promoted alkyne-azide cycloaddition (SPAAC). DBCO-PEG4-Biotin is particularly valuable in applications involving protein labeling, detection, and purification, enhancing the study of biomolecular interactions and cellular processes. Its PEG components improve solubility and stability, making it an essential tool in chemical biology research. -
Biochemical Assay Reagent
Carboxyl diazirine alkyne is a protein cross-linking compound that enables the study of protein interactions and modifications. This reagent is particularly valuable in biochemical assays focused on the inhibition and labeling of the FTO protein using fluorescein derivatives, facilitating advanced research in metabolism and epigenetics. Its unique properties allow for covalent bonding, thereby enhancing the specificity and sensitivity of detection methods in various biological applications. -
Click Chemistry Agent
endo-BCN-NHS carbonate is a versatile click chemistry agent that modifies elastin-like proteins (ELPs) by introducing BCN groups through reaction with lysine residues. This compound facilitates the formation of hydrogels via the strain-promoted azide-alkyne cycloaddition (SPAAC) mechanism, enabling enhanced structural integrity in biomaterials. endo-BCN-NHS carbonate is primarily utilized in cell encapsulation studies, supporting advancements in tissue engineering and regenerative medicine research. -
Click Chemistry Reagent
Tetrazine-Amine monohydrochloride is a click chemistry reagent featuring a tetrazine group, which facilitates covalent labeling of living cells via inverse electron demand Diels-Alder (iEDDA) reactions with TCO-containing molecules. This compound enables precise bioconjugation in various biological studies, making it an essential tool for researchers focusing on protein labeling, drug delivery, and imaging applications. Its ability to promote rapid and selective reactions enhances its utility in the design of targeted therapeutics and biomolecular probes. -
BCN-TPP Probe Control
BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is an alcohol-functionalized cyclooctyne derivative that serves as a precursor for the synthesis of various bioconjugation probes, including BCN-TPP. It facilitates the construction of targeted probes through coupling reactions with carboxyl-containing compounds, such as TPP-COOH. Additionally, BCN-OH functions as a control reagent for experiments involving BCN-TPP, providing a valuable tool for researchers in chemical biology and bioconjugation studies. -
Cross-Linked Peptide
Azide-A-DSBSO crosslinker is a homobifunctional, azide-labeled crosslinking reagent that targets lysine residues through an NHS ester reaction. This membrane-permeable and acid-cleavable compound is particularly useful in cross-linking mass spectrometry (XL-MS) to investigate protein-protein interactions. Its mass spectrometry-cleavable properties enable efficient analysis of cross-linked complexes, facilitating deeper insights into protein dynamics and interactions in biological systems. -
Tetrazines
Methyltetrazine-amine is a tetrazine compound that enables site-specific dual functionalization of bioconjugates. This reagent facilitates the precise modification of biomolecules, making it valuable in the development of targeted therapeutics and imaging agents. Its unique reactivity allows for selective labeling and conjugation, supporting various applications in chemical biology and drug development. -
Click Chemistry Reagent
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a click chemistry reagent featuring an azide functional group. This compound facilitates the efficient and specific labeling of biomolecules, including nucleic acids, lipids, and proteins, making it valuable in various research applications. Its properties allow for high-yield reactions and straightforward conjugation processes, enabling advancements in drug development, bioconjugation, and materials science. -
Long Chain Protein Modification Reagent
Biotin LC hydrazide is a long chain protein modification reagent that specifically targets periodate-oxidized glycoproteins. It facilitates the biotinylation of these proteins, enhancing their detection and isolation in various biological assays. This reagent is widely used in research applications that require the study of glycoprotein functionality and interactions. -
APEX2 Probe
Tyramide alkyne serves as a novel labeling substrate for APEX2 probes, effectively facilitating the detection and enrichment of specific biomolecules. It can be conjugated to various detection moieties through a Copper-catalyzed Azide/Alkyne Cycloaddition (CuAAC) "click" reaction. This compound is instrumental in enhancing spatial resolution in biological imaging and is utilized in advanced proteomics and cellular studies. -
Tetrazines Compound
Methyltetrazine-amine hydrochloride is a tetrazine compound that serves as a versatile reactive moiety for site-specific dual functionalization of bioconjugates. This reagent facilitates efficient labeling and immobilization strategies in chemical biology applications. It can be effectively utilized during protein precipitation in experiments employing trans-cyclooctene, making it a valuable tool for researchers focusing on conjugation methodologies and biomolecular studies. -
DBCO Iridium Catalyst
DBCO Iridium Catalyst functions as a powerful tool for in situ labeling and imaging of biomolecules, including proteins and nucleic acids, in living organisms. Its unique DBCO labeling capability enhances the specificity and efficiency of targeted drug delivery systems. This catalyst is essential for researchers investigating biomolecular interactions and developing advanced imaging techniques in biological systems. -
Azide
Cholesteryl-Teg azide is a cholesterol-modified azide that facilitates bioconjugation reactions. It serves as a valuable ligand for tagging and modifying biomolecules, particularly RNA strands, enabling advanced studies in molecular biology and drug development. Its properties support research in areas such as gene delivery and the synthesis of cholesterol-based therapeutics. -
Click Chemistry Agent
exo-BCN-NHS carbonate is a highly reactive Click Chemistry agent featuring a BCN (bicyclononyne) moiety. It facilitates strain-promoted alkyne-azide cycloaddition (SPAAC), enabling efficient coupling with azide-containing compounds. This reagent is particularly useful for bioconjugation applications, allowing researchers to label biomolecules or proteins selectively and efficiently, enhancing the study of biological systems and interactions. -
Glycoconjugates Label
Biocytin hydrazide is a selective labeling reagent designed for targeting sialic acids, galactose, and other sugars in glycoconjugates through avidin-biotin technology. This compound facilitates the study of glycan structures and their biological roles, aiding in research applications such as glycoprotein analysis, cell surface marker identification, and carbohydrate-protein interactions. Its specificity makes it an invaluable tool for investigating complex carbohydrate moieties in various biological systems. -
Click Chemical
Endo-BCN-L-Lysine is a Click Amino Acid designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. Its unique BCN group enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing partners, facilitating efficient and selective linking in complex molecular assemblies. This reagent is particularly valuable in chemical biology research, allowing for the development of targeted therapeutics and innovative protein degradation strategies. -
Biochemical Assay Reagent
Trivalent GalNAc-DBCO is a versatile biochemical assay reagent designed for efficient oligonucleotide coupling. It facilitates the bioconjugation of GalNAc moieties to oligonucleotides, enhancing targeting and delivery capabilities in nucleic acid research. This compound is particularly useful in developing targeted therapeutic strategies and studying oligonucleotide interactions within biological systems. -
Click Amino Acid
(2E)-TCO-PNB ester functions as a Click Amino Acid and serves as a versatile linker for the synthesis of PROTAC molecules. Its unique TCO group can participate in an inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-containing compounds, facilitating efficient conjugation in bioconjugation strategies. This reagent is suitable for applications in chemical biology, enabling the development of targeted therapeutics and advanced biomolecular constructs. -
Crosslinking Agent
Oxalyldihydrazide is a crosslinking agent that effectively captures carbonylated proteins, making it an essential tool in proteomics research. Its ability to form stable linkages allows for the precise analysis of protein modifications on microchips, facilitating the study of protein interactions and functions. Researchers utilize oxalyldihydrazide to enhance the detection and characterization of biomolecules in diverse applications, including disease biomarker discovery and cellular pathway analysis. -
Amine Reaction Reagent
TCO-PNB ester is an amine-reactive building block designed for the modification of amine-containing molecules. It features a strained trans-cyclooctene (TCO) group that participates in an inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-containing compounds. This reagent is valuable for applications in bioconjugation, enabling precise labeling and modification of biomolecules for use in various biochemical studies and therapeutic developments. -
Biochemical Assay Reagent
TAMRA alkyne, 5-isomer is an alkyne derivative of the fluorescent dye TAMRA, primarily used as a biochemical assay reagent. It enables the enrichment, in-gel fluorescence detection, and identification of O-GlcNAc-modified proteins. This compound participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules and is also reactive in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it valuable for bioconjugation applications in protein labeling and visualization. -
Biochemical Assay Reagent
DBCO-Tetraacetyl mannosamine is a click chemistry reagent featuring a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound is primarily employed in biochemical assays for the modification of glycoproteins and cell surface molecules, enabling applications in biomarker discovery and purification. Furthermore, it serves as a drug carrier in controlled release systems, making it a valuable tool for advancing research in bioconjugation and drug delivery mechanisms. -
PEG Derivative
Methyltetrazine-PEG4-amine hydrochloride is a PEG derivative characterized by the presence of a free amine and a methyltetrazine moiety. This compound serves as a versatile click chemistry reagent, capable of undergoing an inverse electron demand Diels-Alder reaction (iEDDA) with trans-cyclooctene (TCO)-containing molecules. Methyltetrazine-PEG4-amine hydrochloride is valuable in biological research for applications such as bioconjugation, drug delivery, and imaging studies, facilitating the development of targeted therapies and diagnostic tools. -
Biochemical Reagent
DSPE-PEG-DBCO ammonium is a biochemical reagent that facilitates copper-free click chemistry via strain-promoted alkyne-azide cycloaddition (SPAAC) with azido-functionalized peptide ligands. This compound is pivotal in drug delivery and nanoparticle research, enabling precise biomolecule conjugation and enhancing therapeutic efficacy. Its unique properties make it suitable for various applications in bioconjugation and nanomedicine. -
Benzothiadiazine Diuretic
Cyclopenthiazide is a benzothiadiazine diuretic that acts by inhibiting the reabsorption of sodium chloride and water in the distal renal tubules. This mechanism leads to increased renal excretion and antihypertensive effects. It is commonly utilized in research to study diuretic actions and their impact on blood pressure regulation. -
Click Chemistry Catalyst
VHLL-BCN serves as a highly effective catalyst for click chemistry reactions, enhancing the efficiency of various bioconjugation processes. Its utility extends to the development of transcription factor (TF)-PROTACs, facilitating targeted protein degradation research. This reagent is essential for researchers focused on innovative therapeutic strategies and the advancement of drug discovery methodologies.
