Click Chemistry

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  1. Biochemical Assay Reagent

    4-Azide-TFP-amide-PEG4-acid is a biochemical assay reagent designed for efficient conjugation reactions. Featuring an aryl azide that can be photo-activated under UV light (250 to 350 nm), it facilitates the covalent attachment to various biomolecules. The inclusion of a PEG spacer enhances aqueous solubility and minimizes steric hindrance during ligation, while the carboxylic acid moiety allows for amine reactions in the presence of an activator to generate stable amide bonds. This reagent is suitable for applications in bioconjugation chemistry and the development of novel biosensors.
  2. Biochemical Assay Reagent

    6-(Biotinamido)hexylazide is a click chemistry biotinylation reagent that targets alkynes to form stable triazole linkages. This compound is essential for various biochemical assays, enabling efficient labeling of biomolecules for detection and isolation. Its versatility makes it suitable for applications in proteomics, cell biology, and drug discovery, facilitating the study of protein interactions and biological pathways.
  3. Biochemical Assay Reagent

    TCO-PEG2-acid is a click chemistry linker that features a trans-cyclooctene (TCO) moiety and a terminal carboxylic acid, enabling efficient interaction with primary amine groups when activated by agents such as EDC. This reagent exhibits high reactivity with tetrazine through an inverse electron demand Diels-Alder (IEDDA) reaction, facilitating the formation of stable conjugates. The inclusion of a hydrophilic polyethylene glycol (PEG) spacer enhances solubility in aqueous environments, making it suitable for biochemical assays and various bioconjugation applications.
  4. Biochemical Assay Reagent

    Methyltetrazine-amido-Tri-(acid-PEG1-ethoxymethyl)-methane is a versatile click chemistry PEG reagent featuring three carboxylic acid groups and a methyltetrazine moiety. This compound facilitates the formation of stable covalent bonds with TCO-containing compounds through a rapid inverse-electron demand Diels-Alder cycloaddition, notable for its exceptional selectivity and lack of reliance on copper catalysts or elevated temperatures. Additionally, the terminal carboxylic acid can react with primary amine groups using coupling agents such as EDC or HATU to generate stable amide bonds, making it suitable for various biochemical assay applications.
  5. Biochemical Assay Reagent

    4-Azide-TFP-amide-SS-propionic acid is a biochemical assay reagent featuring an aryl azide, a cleavable disulfide bond, and a carboxylic acid. The aryl azide undergoes photo-activation with UV light (250 to 350 nm), facilitating conjugation with various biomolecules. The carboxylic acid is reactive towards amines in the presence of an activator, allowing for the formation of stable amide bonds. The associated disulfide bond can be selectively cleaved using reducing agents, making this compound valuable for applications in protein labeling and conjugation studies.
  6. Biochemical Assay Reagent

    Methyltetrazine-PEG11-DBCO is a TCO-reactive reagent featuring a DBCO group and a hydrophilic PEG spacer. This compound enables the efficient conversion of azide-containing peptides or proteins into tetrazine-modified analogs without the need for catalysts or auxiliary reagents. The DBCO moiety is particularly beneficial for facilitating copper-free Click Chemistry reactions, making this reagent valuable for biochemical assays and labeling applications in chemical biology and therapeutic research.
  7. Biochemical Assay Reagent

    TCO-PEG4-TFP Ester is an amine-reactive labeling reagent, primarily targeting amine-containing biopolymers such as proteins and antibodies. The inclusion of 2,3,5,6-tetrafluorophenol (TFP) provides enhanced hydrolytic stability in aqueous environments, leading to more efficient and reproducible labeling processes. TFP esters react with primary amines to form covalent amide bonds at rates comparable to NHS esters, making this reagent valuable for biochemical assays and various protein modification applications.
  8. Biochemical Assay Reagent

    Methyltetrazine-PEG2-DBCO is a water-soluble reagent designed for efficient bioconjugation through the copper-free Click Chemistry mechanism. Featuring a DBCO moiety linked by a PEG spacer, this compound facilitates the conversion of azido-tagged peptides or proteins into tetrazine-functionalized derivatives without the need for catalysts or auxiliary reagents. Its key biological activity enhances the versatility of biochemical assays and is particularly valuable in the fields of proteomics and materials science.
  9. Biochemical Assay Reagent

    3-Maleimidylpropanoyl hydrazide hydrochloride is a biochemical assay reagent that primarily functions as a crosslinking agent. It facilitates the formation of stable conjugates between thiol-containing biomolecules, making it valuable for labeling and detecting proteins in various assays. This reagent is widely used in life sciences research for studying protein interactions and developing bioconjugates for drug delivery applications.
  10. Biochemical Assay Reagent

    Methyltetrazine-amido-PEG8-amine Trifluoroacetate is a heterobifunctional linker designed for biochemical assays. It features a terminal methyltetrazine that enables efficient reactions with TCO-containing compounds without the need for copper catalysis or elevated temperatures. The terminal amine facilitates specific reactions with NHS esters, while the PEG spacer improves water solubility, enhancing overall reagent performance in various research applications.
  11. Biochemical Assay Reagent

    Bromoacetamido-PEG2-azide is a heterobifunctional polyethylene glycol (PEG) linker that features a reactive bromoacetamido group and a terminal azide moiety. The bromoacetamido component facilitates nucleophilic substitution, enabling covalent attachment to various nucleophiles. The azide group is compatible with alkyne, BCN, and DBCO through Click Chemistry, making this reagent an essential tool for biochemical assays and bioconjugation applications in chemical biology and drug development.
  12. Biochemical Assay Reagent

    m-PEG2-DBCO is a monodisperse polyethylene glycol (PEG) reagent that facilitates copper-free click chemistry. It enables the efficient reaction between dibenzocyclooctyne (DBCO) and azide-containing compounds, making it a valuable tool for bioconjugation applications. This reagent is particularly useful in biochemical assays and labeling techniques where selective and efficient conjugation is required.
  13. Biochemical Assay Reagent

    BP Fluor 546 DBCO is an azide-reactive probe designed for imaging azide-tagged biomolecules through a copper-free click reaction. This reagent offers a stable triazole formation without the need for copper catalysts or elevated temperatures, making it suitable for applications sensitive to copper. The water-soluble, orange-fluorescent dye exhibits absorption and emission maxima at 554 nm and 570 nm, respectively, and is compatible with 488 nm and 532 nm laser lines. BP Fluor 546 DBCO can be conjugated to various biomolecules, including antibodies, peptides, and proteins, facilitating reliable signal generation in imaging and flow cytometry.
  14. Crosslinker

    endo-BCN-PEG4-amine is a versatile crosslinker reagent that utilizes the BCN (Bicyclo[6.1.0]nonyne) moiety, enabling efficient click chemistry reactions with azide-tagged molecules. The attached amine group exhibits reactivity towards carboxylic acids, activated NHS esters, and carbonyls, including ketones and aldehydes. This compound is ideal for applications in bioconjugation, surface modification, and the synthesis of complex biomolecular architectures, facilitating the study of protein interactions, drug delivery systems, and other research applications in chemical biology.
  15. Metal-organic Framework

    2,2'-((1,2,4,5-Tetrazine-3,6-diyl)bis(sulfanediyl))diacetic acid serves as a ligand for metal-organic frameworks (MOFs). This compound is characterized by its ability to stabilize metal ions, enhancing the structural integrity of the framework. It is utilized in research applications involving gas adsorption, catalysis, and sensor development due to its promising electronic and chemical properties.
  16. Metal-organic Framework

    3,6-Di(pyridin-2-yl)-1,4-dihydro-1,2,4,5-tetrazine is a compound with significant potential as a building block for metal-organic frameworks (MOFs). It exhibits unique structural properties that facilitate the coordination of metal ions, enabling the formation of stable and functionalized MOFs. This compound is suitable for research applications in gas storage, catalysis, and drug delivery systems, contributing to advancements in material science and nanotechnology.
  17. Click Chemistry Reagent

    Tetrazine-Amine is a click chemistry reagent featuring a tetrazine functional group that enables covalent labeling of live cells via cycloaddition. This compound undergoes an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, facilitating bioorthogonal reactions in complex biological systems. Tetrazine-Amine is utilized in various research applications, including probes for imaging and tracking biomolecules, as well as in the development of drug delivery systems.
  18. Metal-organic Framework

    1,4-Benzenedicarboxylic acid, 2,3-dihydroxy-, 1,4-dihydrazide, also known as 2,3-Dihydroxyterephthalohydrazide, serves as a key building block in the synthesis of metal-organic frameworks (MOFs). This compound exhibits significant potential in applications related to gas storage, catalysis, and separation technologies. Its dual functional groups enhance coordination with metal ions, thereby facilitating the formation of robust MOF structures suitable for various research applications in material science and chemistry.
  19. Metal-organic Framework

    4,4'-(1,2,4,5-Tetrazine-3,6-diyl)dibenzoic acid serves as a key building block for the synthesis of metal-organic frameworks (MOFs). Its unique structural features facilitate rigorous coordination with metal ions, enhancing the stability and functionality of the resulting frameworks. This compound is invaluable in studies focusing on gas storage, separation processes, and catalysis applications within the field of materials science.
  20. Stable Isotope

    Acetohydrazide-d3 is a deuterium-labeled derivative of Acetohydrazide, functioning as a stable isotope. This compound is utilized in organic synthesis and can undergo catalytic hydrogenation to yield N′-methyl acethydrazide (MAH). It serves as a valuable tool for researchers studying reaction mechanisms and developing novel chemical pathways in organic chemistry.
  21. Metal-organic Framework

    3,6-Di(pyridin-2-yl)-1,2,4,5-tetrazine targets metal-organic frameworks (MOFs) and serves as a versatile building block in their construction. This compound exhibits significant potential for enhancing the structural stability and surface area of MOFs, making it valuable for applications in gas storage, catalysis, and sensing. Its unique chemical properties facilitate the design of innovative materials for advanced technological applications in the fields of energy and environmental science.
  22. Metal-organic Framework

    3,6-Di(pyridin-4-yl)-1,2,4,5-tetrazine serves as a scaffold for the design of metal-organic frameworks (MOFs). This compound exhibits significant coordination properties due to its multi-dentate nature, facilitating the formation of stable MOFs with potential applications in gas storage, catalysis, and sensing. Its unique structural features make it a valuable tool for researchers exploring advanced materials in inorganic chemistry.
  23. Metal-organic Framework

    3,6-Di(pyridin-3-yl)-1,2,4,5-tetrazine is a metal-organic framework (MOF) known for its exceptional ligand properties. It exhibits significant interactions with metal ions, facilitating the formation of stable and structured frameworks. This compound is widely utilized in research applications aimed at developing advanced materials for gas storage, catalysis, and sensing technologies. Its unique structure makes it a valuable tool for exploring metal coordination and enhancing material functionalities.
  24. Stable Isotope

    Chlorothiazide-13C,15N2 is the stable isotope-labeled form of Chlorothiazide, incorporating 13C and 15N isotopes. Chlorothiazide functions as an orally active diuretic and anti-hypertensive agent, primarily targeting renal sodium-coupled transport processes. This reagent is beneficial for research applications involving metabolic studies, pharmacokinetic assessments, and isotopic tracing in physiological experiments.
  25. Stable Isotope

    Hydroflumethiazide-13C,d2 is a stable isotope-labeled form of Hydroflumethiazide, incorporating both deuterium and carbon-13 isotopes. This compound serves as an important tool in pharmacokinetic studies and metabolic research, allowing for precise tracking of drug metabolism and distribution in biological systems. Its application extends to studies involving the pharmacological effects and mechanisms of thiazide diuretics in various physiological contexts.
  26. Stable Isotope

    Potassium Azide-15N is a stable isotope-labeled compound primarily utilized in research involving stable isotope labeling and mass spectrometry. It serves as a valuable tool in metabolic studies, tracing nitrogen incorporation in biological systems, and advancing the understanding of azide chemistry in various applications. This compound supports research in fields such as chemical biology, metabolic profiling, and environmental studies.
  27. Stable Isotope

    4-Hydroxybenzhydrazide-d4 is a deuterated analogue of 4-Hydroxybenzohydrazide, serving as a stable isotope labeled reagent. This compound is primarily utilized in quantitative mass spectrometry and tracing studies in various biological research applications. Its use enables enhanced sensitivity and specificity in the analysis of metabolic processes and biomolecular interactions.
  28. Stable Isotope

    4-Benzyl-1-piperazineacetic Acid Hydrazide-d8 is a stable isotope-labeled derivative of 1-Piperazineacetic acid, 4-(phenylmethyl)-, hydrazide. This compound is primarily utilized in mass spectrometry and other analytical techniques, allowing for precise quantification and tracking of biological pathways. It serves as a valuable tool in pharmacokinetic studies, drug metabolism research, and isotopic labeling applications, facilitating enhanced understanding of complex biological systems.
  29. Stable Isotope

    4-Methylbenzenesulfonhydrazide-d3 is a stable isotope-labeled derivative of 4-Methylbenzenesulfonhydrazide. This compound is utilized primarily in mass spectrometry and metabolic studies, serving as a tracer in biological research. Its deuterium labeling enables enhanced quantification and tracking of biochemical reactions, making it a valuable tool in the study of hydrazine derivatives and related biological pathways.
  30. Stable Isotope

    Adipic acid dihydrazide-d8 is a deuterium-labeled derivative of adipic acid dihydrazide, primarily serving as a stable isotope for research applications. This compound can be utilized in metabolic studies and isotopic labeling experiments to trace pathways in biological systems. Its unique isotopic signature enhances the accuracy of analytical techniques such as mass spectrometry, facilitating deeper insights into chemical reactions and biological processes.
  31. Stable Isotope

    Semicarbazide-13C,15N2 hydrochloride is a stable isotope labeled compound featuring both 15N and 13C isotopes. It primarily serves as a precursor in the synthesis of various nitrogen-containing compounds and can be utilized in studies involving metabolic pathways and tracer experiments. Its stable isotopic labeling makes it an essential reagent for researchers investigating the mechanisms of action and metabolism of biologically relevant molecules.
  32. Stable Isotope

    Benzylhydrochlorothiazide-d5 is a deuterated analog of Benzylhydrochlorothiazide, serving as a stable isotope labeled compound. This reagent is primarily utilized in quantitative analysis, facilitating studies in pharmacokinetics and metabolism of thiazide diuretics. Its stable isotope nature allows for precise tracking and differentiation in biological assays and isotope labeling experiments.
  33. Fluorescent Dye

    BP Fluor 488 Alkyne is a fluorescent dye specifically designed for labeling in Click Chemistry reactions. It conjugates effectively with azide-modified biomolecules, including antibodies, proteins, peptides, and amino-modified oligonucleotides. With an excitation peak at 499 nm and emission peak at 520 nm, this dye allows for enhanced visualization in applications such as microscopy and flow cytometry. BP Fluor 488 Alkyne is a pure 5-sulfonated rhodamine derivative, providing consistent results free from lot-to-lot variation.
  34. Fluorescent Dye

    MB 543 DBCO is a fluorescent dye featuring a terminal DBCO group, which enables its application in copper-free Click Chemistry reactions through strain-promoted cycloaddition. This highly hydrophilic, water-soluble compound exhibits strong orange fluorescence with a maximum absorption at 543 nm and emission at 566 nm. Additionally, MB 543 DBCO demonstrates excellent stability across a broad pH range from 3 to 10, making it suitable for various biological imaging and labeling applications in research.
  35. Fluorescent Dye

    BP Fluor 350 Azide is a blue-fluorescent dye designed for bioorthogonal labeling, functioning primarily through copper-catalyzed azide-alkyne cycloaddition (CuAAC) and copper-free click chemistry with strained cyclooctynes to form stable triazole compounds. This water-soluble, moderately photostable probe is optimally excited at 350 nm and is ideal for applications in imaging and flow cytometry, providing robust signal generation for high-abundance target visualization. BP Fluor 350 is particularly suitable for experiments requiring direct imaging due to its outstanding brightness and stability.
  36. Fluorescent Dye

    BP Fluor 430 Picolyl Azide is a specialized fluorescent dye designed for enhanced signal amplification through its unique copper-chelating motif. This compound effectively increases the local concentration of Cu(I) at the reaction site, significantly accelerating the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction without the need to elevate the concentrations of azide or copper catalysts. Utilizing BP Fluor 430 Picolyl Azide allows for at least a tenfold reduction in copper catalyst concentration while maintaining optimal labeling efficiency, making it ideal for the detection of low-abundance targets or applications necessitating increased signal intensity.
  37. Dye

    BP Fluor 488 Azide is a multifunctional fluorescent dye that primarily targets cellular structures and biomolecules. This dye plays a crucial role in biological research by enabling the visualization and tracking of cell dynamics, facilitating the evaluation of cellular functions, and enabling the differentiation of cell types. Its versatile applications extend across fundamental research and clinical diagnostics, as well as in textile processing, food coloring, and advanced technologies such as dye-sensitized solar cells.
  38. Fluorescent Dye

    BP Fluor 430 Azide is a water-soluble, green-fluorescent azide probe that targets terminal alkynes through copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strained cyclooctynes via copper-free click chemistry, forming stable triazole compounds. It exhibits strong fluorescent properties with an excitation maximum at 432 nm and an emission maximum at 539 nm, demonstrating excellent brightness and photostability. This versatile probe remains pH-insensitive across a range of 4 to 10, making it suitable for a variety of biological applications, including the detection of low-abundance alkyne-tagged biomolecules.
  39. Fluorescent Dye

    BP Fluor 350 Picolyl Azide is a blue-fluorescent azide-activated probe designed for efficient labeling of biomolecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC). Additionally, it can react with strained cyclic alkynes through copper-free click chemistry to form stable triazole linkages. This compound is valuable for fluorescence imaging and in studies requiring precise biomolecular tagging, allowing researchers to visualize and track interactions in various biological systems.
  40. Fluorescent Dye

    Rhodamine B carbohydrazide is a fluorescent dye that utilizes the spirocyclic structure of Rhodamine B to target specific reactive species. This compound exhibits strong fluorescence and is applicable for the detection of copper ions (Cu2+), mercury ions, peroxynitrite, hydroxyl radicals, and nitric oxide (NO). Its utility in biological research includes fluorescence imaging and monitoring oxidative stress, making it valuable for studies in environmental monitoring and cellular processes.
  41. Fluorescent Dye

    Cy3 hydrazide is a cyanine dye linker designed for the selective labeling of carbonyl-containing molecules, including aldehydes and ketones. This reagent effectively labels proteins such as antibodies and glycoproteins following periodate oxidation, as well as proteins affected by oxidative stress or deamination. Cy3 hydrazide is suitable for various fluorescent applications and is compatible with a wide range of fluorescence instrumentation, facilitating advanced biochemical and cellular studies.
  42. Fluorescent Dye

    FAM tetrazine, 5-isomer is a fluorescent dye characterized by its terminal tetrazine group, facilitating rapid click chemistry reactions with trans-cyclooctene (TCO). This compound serves as a versatile labeling agent in various biological applications, including protein tagging, cellular imaging, and detection of biomolecular interactions. Its high fluorescence and effective reactivity make it a valuable tool for researchers in fields such as biochemistry and molecular biology.
  43. Fluorescent Dye

    BP Fluor 350 Azide Plus is a fluorescent dye characterized by its terminal azide group. This compound exhibits maximum absorption at 340 nm and emission at 440 nm, making it suitable for various imaging applications. The incorporation of a copper-chelating system facilitates the formation of robust copper complexes, serving as both reactants and catalysts in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. It is ideally suited for studies requiring efficient labeling and detection in biological systems.
  44. Fluorescent Dye

    BP Fluor 555 Azide is a fluorescent dye designed for the labeling of biomolecules through copper-catalyzed or copper-free click chemistry. Exhibiting bright orange fluorescence, it has optimal excitation wavelengths of 532 nm and 555 nm, making it suitable for imaging applications with TRITC filter sets. The dye demonstrates pH insensitivity from pH 4 to pH 10, facilitating the detection of low-abundance targets when conjugated to antibodies, peptides, or proteins. Its high brightness and photostability enhance the visibility and reliability of fluorescent imaging techniques in various biological research applications.
  45. Fluorescent Dye

    BP Fluor 430 Alkyne is a green-fluorescent alkyne-activated probe designed for the imaging of azide-containing biomolecules with moderate to high abundance. It utilizes a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction to produce a stable triazole linker. This probe exhibits bright and photostable fluorescence, optimally excited near 430 nm, and is water-soluble, maintaining pH-independent fluorescence across a wide range. Applications include cellular imaging and visualization of biomolecular interactions.
  46. Fluorescent Dye

    MB 660R DBCO is a far-red fluorescent dye, exhibiting strong fluorescence emission at approximately 685 nm. With an absorption maximum at around 665 nm, it can be effectively excited using 633 or 635 nm lasers. This dye is characterized by high water solubility and maintains stability across a broad pH range from 4 to 10. Its robust photostability and brightness make MB 660R DBCO suitable for various applications in fluorescent imaging and labeling in biological research.
  47. Fluorescent Dye

    BP Fluor 405 DBCO is a blue-fluorescent dye that utilizes copper-free click chemistry for targeted labeling of azides, resulting in stable triazole formation. Its excitation wavelength is optimal for use with the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. This dye is particularly useful in multi-color applications such as flow cytometry and super-resolution microscopy techniques like STORM, enabling precise visualization in complex biological samples.
  48. Fluorescent Dye

    BP Fluor 594 alkyne is a fluorescent dye designed for the specific imaging of azide-containing biomolecules. This probe utilizes a copper-catalyzed azide-alkyne cycloaddition (CuAAC) mechanism to react with azides, resulting in the formation of a stable triazole linkage. Its bright red fluorescence makes it an effective tool for various biological research applications, particularly in tracking biomolecular interactions and localization studies.
  49. Fluorescent Dye

    R6G azide, 5-isomer is a xanthene-derived fluorescent dye characterized by a terminal azide group. This compound can undergo Click Chemistry with alkynes, BCN, and DBCO, forming a stable triazole linkage. Its unique structure and fluorescent properties make it suitable for a range of applications, including bioimaging and labelling studies in chemical research.
  50. Fluorescent Dye

    BP Fluor 532 Azide Plus is a fluorescent dye featuring a terminal azide group, primarily used in click chemistry applications. With a maximum absorption at 532 nm and emission at 554 nm, this compound exhibits robust fluorescence properties. Its unique structure incorporates a copper-chelating system, facilitating the formation of stable copper complexes that function as both reactants and catalysts in CuAAC (Copper-catalyzed Azide-Alkyne Cycloaddition) reactions, making it ideal for a variety of biological and chemical research applications.

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