Catalog No.
Product Name
Application
Product Information
Citations
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Tubulin Modulator
Isocephalomannine is a tubulin modulator that exhibits cytotoxic activity against cancer cells. This compound disrupts microtubule dynamics, leading to apoptotic cell death, particularly in breast cancer cells. Isocephalomannine is a valuable tool for research applications focused on cancer biology and therapeutic strategies targeting microtubule stabilization and destabilization. -
Tubulin Inhibitor
Tubulin polymerization-IN-47 is a potent inhibitor of tubulin polymerization, specifically targeting mitotic processes. This compound demonstrates significant inhibitory effects on neuroblastoma cancer cell proliferation, exhibiting IC50 values of 7 nM and 12 nM against the Chp-134 and Kelly cell lines, respectively. It is a valuable tool for research in cancer biology, particularly in the study of cell division and the mechanisms of tumor growth. -
Tubulin Polymerization Inhibitor
Antiproliferative agent-14 is a potent tubulin polymerization inhibitor with an IC50 of 3.41 μM. This compound demonstrates significant antiproliferative activity, effectively disrupting cell cycle progression by arresting cells at the G2/M phase. It is a valuable tool for studying tumor biology and the mechanisms underlying cell division in cancer research. -
Tubulin/NEDDylation Inhibitor
Tubulin/NEDDylation-IN-1 (compound C11) is a potent dual inhibitor targeting tubulin and NEDDylation, exhibiting an IC50 of 2.40 μM for tubulin. This compound effectively disrupts microtubule dynamics and inhibits the NEDDylation process, a crucial post-translational modification involving the attachment of the ubiquitin-like protein NEDD8 to target proteins. By forming hydrogen bonds with key residues in tubulin and the NEDD8 activating enzyme (NAE) through its methoxy and dithiocarbamate functionalities, Tubulin/NEDDylation-IN-1 demonstrates significant anti-proliferative activity and serves as a valuable tool for research investigating cellular proliferation and microtubule regulation. -
Tubulin Inhibitor
Tubulin Inhibitor 6 targets tubulin polymerization, displaying potent inhibitory activity across various cancer cell lines. It demonstrates an IC50 of 0.87 μM for tubulin polymerization and effectively inhibits the growth of K562 cells with an IC50 of 840 nM. This compound is useful for research applications focused on elucidating mechanisms of cancer cell proliferation and treatment strategies. -
Microtubule/Tubulin Inhibitor
OSIP-486823 is a novel tubulin inhibitor that disrupts microtubule dynamics. It demonstrates significant biological activity by affecting protein kinase G (PKG) pathways alongside its microtubule-interfering properties. This dual action positions OSIP-486823 as a valuable tool for studying cell division, cytoskeletal organization, and various signaling pathways in cancer research and other related fields. -
Tubulin Inhibitor
Tesetaxel is a taxane tubulin inhibitor that demonstrates oral activity and effective brain penetration. It inhibits tubulin depolymerization with an IC50 of 0.44 μM, leading to a reduction in cancer cell proliferation. This compound exhibits potent antitumor effects, particularly against P-glycoprotein-positive cancer cells, making it valuable for research applications related to solid tumors, liver metastasis, and advanced breast cancer. -
Tubulin Targeting Agent
PM534 is a tubulin-targeting agent that inhibits tubulin assembly with IC50 values ranging from 0.8 to 3.2 nM. By binding to the colchicine site of tubulin, PM534 disrupts microtubule dynamics, demonstrating significant antitumor activity. This compound is valuable for research applications in cancer biology, particularly in studies focused on cell division and microtubule-targeting therapies. -
Tubulin Polymerization Inhibitor
S516 is a potent tubulin polymerization inhibitor with an IC50 of 4.29 μM. This active metabolite of CKD-516 exhibits significant antitumor activity, making it a valuable tool for cancer research. Its ability to disrupt microtubule dynamics may provide insights into cell cycle regulation and potential therapeutic strategies against cancer. -
Tubulin Polymerisation Inhibitor
Tubulin Inhibitor 27 (DYT-1) is a potent tubulin polymerisation inhibitor with an IC50 value of 25.6 μM. This compound exhibits significant anti-angiogenic and antitumor activities, making it valuable for research into cancer biology and potential therapeutic applications. Its ability to disrupt microtubule dynamics can aid investigations into cellular processes related to tumor growth and metastasis. -
Tubulin Inhibitor
Tubulin Inhibitor 22 is a potent inhibitor of tubulin, demonstrating significant anti-angiogenic and anti-cancer properties. It effectively arrests the MGC-803 cell cycle at the G2/M phase, leading to a dose-dependent induction of Caspase-mediated apoptosis through mitochondrial dysfunction. This compound is valuable for research applications in cancer biology and the study of cell cycle regulation. -
Tubulin Inhibitor
ABI-274 is a potent tubulin inhibitor that targets the colchicine binding site. This compound significantly enhances cancer cell apoptosis in vitro when used in combination with vemurafenib, exhibiting strong synergistic effects. In vivo studies demonstrate its efficacy in vemurafenib-resistant xenograft models in nude mice, making ABI-274 a critical tool for research on melanoma and potential therapeutic strategies in resistant cancer forms. -
Tubulin Inhibitor
Tubulin inhibitor 8 (Compound 33b) is a potent inhibitor of tubulin polymerization, demonstrating an IC50 value of 0.73 μM. This compound effectively inhibits the growth of K562 cancer cells, achieving an IC50 of 14 nM. Tubulin inhibitor 8 is valuable for studies in cancer research, particularly in evaluating mechanisms of action related to cytoskeletal dynamics and potential therapeutic interventions in tumor proliferation. -
Tubulin Inhibitor
Tubulin Inhibitor 7 is a potent inhibitor of tubulin polymerization, targeting microtubule dynamics critical for cell division. With an IC50 of 0.52 μM, it effectively disrupts tubulin assembly, exhibiting significant anti-proliferative activity in various cancer cell lines. Notably, Tubulin Inhibitor 7 demonstrates an IC50 of 11 nM against K562 cells, making it a valuable tool for cancer research and studies focused on mitotic disruption. -
Tubulin Inhibitor
Tubulin Inhibitor 29 is a potent inhibitor of tubulin assembly, exhibiting an IC50 value of 1.2 µM. This compound demonstrates significant antiproliferative activity, with an IC50 value of 7.5 µM against MCF-7 breast cancer cells. By binding to the colchicine site on tubulin, Tubulin Inhibitor 29 disrupts microtubule dynamics, making it a valuable tool for cancer research and studies focused on cell cycle regulation. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-63 is a potent inhibitor of tubulin polymerization, demonstrating an IC50 value of 0.29 μM in MES-SA cells. This compound disrupts microtubule dynamics, making it a valuable tool for cancer research. It aids in the exploration of cellular responses to tubulin modulation and contributes to the understanding of tumor biology and therapeutic strategies. -
Tubulin Inhibitor
Tubulin Inhibitor 26 is a potent indazole derivative targeting tubulin. It exhibits low nanomolar potency against various cancer cell lines, including HepG2, HCT116, SW620, HT29, and A549. This compound effectively induces G2/M phase arrest and promotes apoptosis in tumor cells. Furthermore, Tubulin Inhibitor 26 demonstrates the ability to suppress tumor growth in vivo while maintaining normal body weight in mice. -
Tubulin/FTase Inhibitor
Tubulin polymerization-IN-25 is a dual inhibitor targeting tubulin polymerization and farnesyl transferase (FTase), exhibiting IC50 values of 1.11 μM and 0.39 μM, respectively. This compound demonstrates significant cytotoxicity and potent antitumor activity, making it a valuable tool for cancer research. Its ability to disrupt microtubule dynamics and inhibit protein farnesylation underscores its potential in therapeutic applications focused on tumor growth suppression. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-87 is a potent inhibitor of tubulin polymerization. This compound disrupts the assembly of microtubules, resulting in G2/M cell cycle arrest and exhibiting significant anti-proliferative effects. It is particularly effective against ovarian cancer, providing valuable insights for research applications in cancer biology and therapeutic development. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-10 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 of 4.25±0.75 μM. This compound demonstrates significant anti-tumor activity, making it a valuable tool for cancer research and studies focusing on microtubule dynamics. Its ability to disrupt tubulin assembly can be leveraged in the investigation of various cancer therapies. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-37 is an effective tubulin polymerization inhibitor, exhibiting an IC50 value of 2.3 μM. By binding to the colchicine site on tubulin, it disrupts the normal polymerization process and inhibits colchicine binding. This compound is valuable in cancer research, particularly in studying various lymphomas and their underlying mechanisms. -
Microtubule/Tubulin Modulator
Fosbretabulin tromethamine is a tubulin modulator that disrupts microtubule dynamics. It acts as a vascular disrupting agent, primarily targeted for the treatment of anaplastic thyroid carcinoma (ATC) by inducing acute, reversible reductions in tumor blood flow and resulting in central necrosis. This compound is instrumental in researching tumor vasculature and assessing therapeutic strategies aimed at disrupting blood supply to tumors. -
Tubulin inhibitor
Tubulin Inhibitor 15 is a potent compound that disrupts microtubule dynamics by binding to tubulin. This reagent demonstrates significant antiproliferative activity, exhibiting cytotoxic effects specifically in HepG2 liver cancer cells. It is a valuable tool for research focused on cancer biology and the mechanisms of cell division and proliferation. -
Tubulin Inhibitor
BNZ-111 is an orally bioavailable inhibitor of tubulin, targeting microtubule dynamics. This compound exhibits significant antitumor activity, making it a valuable tool for cancer research. BNZ-111 can be utilized in studies focused on the mechanistic understanding of microtubule-targeting therapies and their potential clinical applications in oncology. -
Tubulin Inhibitor
Tubulin Inhibitor 44 is a potent inhibitor targeting tubulin, disrupting its function in microtubule dynamics. This compound exhibits significant cytotoxicity in cancer cell lines such as NCI-H460, BxPC-3, and HT-29, with IC50 values of 0.96 nM, 0.66 nM, and 0.61 nM, respectively. Its efficacy makes it a valuable tool for research in cancer biology and drug discovery focused on microtubule-targeting agents. -
Tubulin Inhibitor
Ohchinolide B is a potent tubulin inhibitor that effectively disrupts microtubule polymerization with an IC50 of 2.3 μM. This compound induces G2/M phase cell cycle arrest and activates mitochondrial apoptotic pathways, making it a valuable tool for studying cancer biology. Ohchinolide B is particularly promising for research involving solid tumors, including breast and lung cancer. -
Tubulin Inhibitor
3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl is a potent tubulin inhibitor with an IC50 of 10 μM, effectively inhibiting tubulin polymerization. This stilbenoid compound enhances the cytotoxic effects of SN-38 in BCRP-transduced cancer cells, making it a valuable tool for cancer research. Its application is particularly relevant in the study of breast cancer, where it can help elucidate mechanisms of drug resistance and potential therapeutic strategies. -
Tubulin Inhibitor
Tubulin Inhibitor 12 is a selective antagonist of tubulin with an IC50 value of 25.3 μM. This compound exhibits significant anti-tumor and anti-proliferative activities, making it a valuable tool for cancer research. It is ideally suited for studies focused on cell cycle regulation and mechanisms of tumor growth inhibition. -
Tubulin polymerization Inhibitor
Tubulin polymerization-IN-29 is a potent inhibitor of tubulin polymerization, effectively disrupting microtubule dynamics. This compound demonstrates significant antiproliferative activity and is capable of inducing cell cycle arrest in HeLa cells at the G2/M phase. It serves as a valuable tool for research involving cancer biology and cell proliferation studies. -
Tubulin Polymerization Inhibitor
Tubulin Polymerization-IN-52 is a selective inhibitor of tubulin polymerization, demonstrating an IC50 of 2.9 μM. This compound disrupts microtubule dynamics, making it a valuable tool for studying cytoskeletal function and cell division. Its inhibitory effects on tubulin polymerization can be leveraged in cancer research and investigations into related disorders. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-55 is a potent inhibitor of tubulin polymerization, disrupting microtubule dynamics. This reagent exhibits significant antiproliferative activity against various cancer cell lines, including A549, K562, HepG2, MDA-MB-231, and HFL-1, with IC50 values of 8, 3, 9, 24, and 62 nM, respectively. It serves as a valuable tool for researchers studying cancer biology and cellular mechanisms involving microtubules. -
Tubulin Polymerization/Akt Pathway Inhibitor
KS-99 is an inhibitor that targets both tubulin polymerization and the Akt signaling pathway. This compound demonstrates significant biological activity by inhibiting cancer cell proliferation and inducing apoptosis in various cancer cell types. KS-99 is suitable for research applications involving colorectal cancer, breast cancer, lung epithelial cancer, and melanoma. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-77 is a potent inhibitor of tubulin polymerization, specifically targeting the microtubule dynamics crucial for cell division. This compound exhibits notable anti-glioblastoma activity by inducing G2/M phase arrest and promoting apoptosis in glioblastoma cells. Additionally, Tubulin polymerization-IN-77 is characterized by significant permeability across the blood-brain barrier and effectively reduces tumor cell migration, making it a valuable reagent for cancer research applications focused on glioblastoma therapeutics. -
Tubulin Inhibitor
ALB-109564 hydrochloride, a tubulin inhibitor, effectively disrupts mitosis in cancer cells, leading to cytotoxicity. This compound is utilized in research focused on cancer biology and treatment strategies, particularly in studies examining the mechanisms of cell division and potential therapeutic interventions for tumor growth. Its ability to impair microtubule dynamics makes it a valuable tool for investigating novel anti-cancer modalities. -
Microtubule/Tubulin
Microtubule Inhibitor 3 targets tubulin, disrupting microtubule dynamics and resulting in cytotoxic activity against diverse human cancer cell lines. With an IC50 value of 14.0 nM in NCI-H460 cells, this compound, along with its analogs, demonstrates potent efficacy in inhibiting cell proliferation. Its applications extend to cancer research, particularly in studying microtubule-targeted therapies. -
Tubulin Inhibitor
Neuroinflammatory-IN-3 is a tubulin inhibitor that exhibits anti-neuroinflammatory properties. It acts by preventing tubulin polymerization, which disrupts microtubule dynamics. This compound has demonstrated potential as an effective antitumor agent, making it valuable for research in cancer biology and neuroinflammatory diseases. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-8 is a potent inhibitor of tubulin polymerization, primarily targeting microtubule dynamics. It effectively induces G2/M phase cell cycle arrest in HCT116 tumor cells, demonstrating a significant inhibitory potency with an IC50 value of 12.7 μM. This compound is valuable for research applications in cancer biology, particularly in studies focused on tumor cell proliferation and microtubule-targeting therapies. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-20 is a potent inhibitor of tubulin polymerization, targeting the assembly of microtubules crucial for cell division. This compound exhibits significant potential in the study of breast cancers and chemoresistant colon cancers, facilitating research into mechanisms of resistance and offering insights for therapeutic strategies. Its effectiveness in disrupting microtubule dynamics makes it a valuable tool for cancer research applications. -
Tubulin Inhibitor
Tubulin Inhibitor 20 is a potent inhibitor of tubulin, disrupting microtubule dynamics and thereby affecting cellular processes such as mitosis and intracellular transport. This compound demonstrates significant anti-cancer activity, making it a valuable tool for research into cancer biology and therapeutic development. Its ability to inhibit tubulin polymerization positions it as a critical reagent for studies aimed at understanding tumor progression and the mechanisms of action of anti-cancer therapies. -
Tubulin Inhibitor
Cemadotin hydrochloride is a potent tubulin inhibitor that disrupts microtubule dynamics, leading to cell cycle arrest in the mitotic phase. With a Ki value of 1 μM, it effectively inhibits cell proliferation in vitro and reduces tumor xenograft growth in murine models. This compound is an important tool for investigating anticancer mechanisms and potential therapeutic applications in cancer research. -
Tubulin Inhibitor
IKP-104 is a potent tubulin inhibitor with an IC50 of 1.31 μM, targeting microtubule polymerization to arrest cells in mitosis during the M phase. This compound induces cytoskeletal microtubule depolymerization, effectively inhibiting the growth of various mouse and human tumor cell lines. Additionally, IKP-104 demonstrates notable anti-tumor effects in mouse ascites tumors and lung cancer models, making it a valuable tool for research in leukemia, lung cancer, and melanoma. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-15 is a selective inhibitor of tubulin polymerization, effectively disrupting microtubule dynamics. This compound exhibits significant potential in cancer research by hindering cell division and inducing apoptosis in tumor cells. It can be utilized to study the mechanisms of cancer progression and the role of microtubules in cellular processes. -
Tubulin Destabilizer
7-Benzoyloxindole is a tubulin destabilizer that disrupts microtubulin structure, leading to inhibited tumor cell growth. This compound is particularly relevant for research applications in gastric cancer and lung cancer, making it a valuable tool for studying tumor dynamics and potential therapeutic strategies. -
Tubulin Inhibitor
SPA107 is a tubulin inhibitor that prevents tubulin polymerization, demonstrating potent antimitotic activity with an IC50 of 0.5 nM. In addition, SPA107 exhibits significant cytotoxic effects in p53 mutated MCF-7 cells, with an IC50 of 0.5 nM. This compound is valuable for research in cancer biology, particularly in studies focused on mitotic disruption and the mechanisms underlying drug resistance. -
Tubulin Inhibitor
HD-800 is a potent tubulin inhibitor, exhibiting an IC50 of 4.3 nM and an EC50 for depolymerization of 24 nM. This compound is valuable for generating the radioactive tracer [11C]HD-800, which is capable of penetrating the blood-brain barrier. [11C]HD-800 serves as a useful tool for positron emission tomography (PET) applications in studying various neurological disorders. -
Tubulin Inhibitor
isoCA-4 is a tubulin polymerization inhibitor derived from Combretastatin A4. It exhibits significant anti-proliferative activity, making it a valuable tool for studying cancer cell growth and metastasis. This compound can be utilized in research applications focused on tumor biology and the development of novel cancer therapeutics. Its mechanism of action provides insights into disrupting microtubule dynamics in cellular systems. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-27 is a selective inhibitor of tubulin polymerization, disrupting microtubule dynamics and thereby arresting the cell cycle at the G2/M phase. This compound induces apoptosis in cancer cells, making it a valuable tool for studying cell cycle regulation and apoptosis mechanisms in various research applications. It is suitable for investigations into cancer biology and therapeutic strategies targeting microtubule assembly. -
Microtubule/Tubulin Inhibitor
BP-M345 is a potent microtubule/tubulin inhibitor that effectively targets cancer cells while demonstrating low toxicity to non-tumor cells. This compound exhibits significant antiproliferative activity, with a GI50 value ranging from 0.17 to 0.45 μM, making it an important tool for cancer research and therapeutic studies. Its ability to selectively inhibit cancer cell proliferation positions BP-M345 as a valuable reagent for exploring cancer biology and potential treatment options. -
Tubulin Inhibitor
Tubulin inhibitor 18 is a potent inhibitor of tubulin, primarily functioning through disruption of microtubule polymerization. As a chalcone derivative, it exhibits significant anti-proliferative activity in various cancer cell lines. This compound is valuable for research applications targeting cancer diseases, enabling further investigation into tubulin dynamics and therapeutics. -
Inhibitors of Tubulin Polymerization
KGP591 is a potent inhibitor of tubulin polymerization with an IC50 of 0.57 µM. It effectively induces G2/M phase stagnation, inhibits cell migration, and disrupts microtubule structure and cell morphology in MDA-MB-231 human breast cancer cells. Additionally, KGP591 exhibits notable antitumor activity in an orthotopic kidney cancer model (RENCA), making it a valuable reagent for cancer research applications.
