Catalog No.
Product Name
Application
Product Information
Citations
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Tubulin Inhibitor
Tubulin polymerization-IN-12 is a potent tubulin polymerization inhibitor with an IC50 of 0.75 μM. By disrupting normal tubulin assembly, it effectively arrests the cell cycle at the G2/M phase, leading to significant cytotoxic effects against cancer cells. This compound is valuable for research in cancer biology and the mechanisms of cell cycle regulation. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-16 is a potent tubulin polymerization inhibitor designed to disrupt microtubule dynamics. This compound demonstrates significant anti-cancer activity with IC50 values ranging from 0.084 to 0.221 μM, effectively inducing cell cycle arrest at the G2/M phase in SGC-7901 cells. Its ability to inhibit tubulin polymerization makes it a valuable tool for research in cancer biology and therapeutic development. -
Tubulin Polymerisation Inhibitor
N-Acetylcolchinol phosphate is a potent inhibitor of tubulin polymerization. It binds to the tubulin cytoskeleton in the endothelial cells of tumor blood vessels, disrupting microtubule dynamics. This compound is valuable in anti-cancer research, providing insights into tumor vasculature and potential therapeutic strategies. Its application facilitates the study of tumor progression and vascularization in various cancer models. -
Tubulin Inhibitor
Tubulin Inhibitor 49 is a potent tubulin polymerization inhibitor with an IC50 value of 48 μM. This compound disrupts the microtubule network, leading to G2 phase cell cycle arrest and demonstrating cytotoxicity with an IC50 of 8.8 μM in HeLa cells. Tubulin Inhibitor 49 serves as a valuable tool for researching cervical cancer and understanding the mechanisms of microtubule dynamics in cancer cell proliferation. -
Tubulin Inhibitor
Tubulin polymerization-IN-48 is a potent inhibitor of tubulin polymerization, demonstrating the ability to disrupt microtubule networks. This compound exhibits significant anti-proliferative activity in neuroblastoma cancer cell lines, with IC50 values of 79 nM for Chp-134 and 165 nM for Kelly cells. Its mechanism makes it a valuable tool for research in cancer biology and cellular dynamics. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-36 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 of 2.8 μM. This compound selectively binds to the colchicine site of tubulin, thereby obstructing colchicine binding and disrupting microtubule formation. Tubulin polymerization-IN-36 is valuable for researching various cancers, including lymphomas, and provides insights into the mechanisms of tumorigenesis and cell division. -
Microtubule/Tubulin Inhibitor
Denibulin is a microtubule-tubulin inhibitor that reversibly disrupts microtubule assembly, affecting the cytoskeleton of tumor vascular endothelial cells. This novel vascular-disrupting agent exhibits tolerability and shows potential for anti-vascular effects, making it a candidate for further research in cancer therapy applications. Its mechanism offers insights into the modulation of tumor vasculature, supporting its exploration in studies of tumor growth and metastasis. -
Tubulin Inhibitor
Tubulin Inhibitor 28 is a highly effective tubulin inhibitor, demonstrating an IC50 value of 1.2 µM. This compound exhibits significant anti-proliferative activity in MCF-7 breast cancer cell lines, making it a valuable tool for cancer research and studies focusing on cell division and cytoskeletal dynamics. Its ability to disrupt microtubule formation suggests potential applications in exploring therapeutic strategies for cancer treatment. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-19 is a potent inhibitor of tubulin polymerization, acting on microtubule dynamics. This compound is relevant for studying the mechanisms underlying breast cancers and chemoresistant colon cancers, providing insights into tumor biology and potential therapeutic targets. Its specificity for tubulin makes it a valuable tool in cancer research and drug development. -
Tubulin Polymerization Inhibitor
Glochidiol is an orally active inhibitor of tubulin polymerization, exhibiting an IC50 of 2.76 μM. This compound demonstrates significant anti-cancer activity and is utilized in research applications focused on cancer cell proliferation and microtubule dynamics. Glochidiol's mechanism of action makes it a valuable tool for studying cancer therapeutics and cell cycle regulation. -
Tubulin Polymerization Inhibitor
NSC 330770 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 value of 2 μM. This compound enhances GTPase activity and promotes the formation of abnormal polymer structures in tubulin. NSC 330770 has valuable applications in cancer research and studies examining microtubule dynamics. -
Tubulin Inhibitor
Phomopsinamine A is a potent tubulin inhibitor that effectively disrupts tubulin polymerization, exhibiting an IC50 of 0.53 μM. It inhibits the binding of Vinblastine to tubulin (IC50 = 0.56 μM) while enhancing the binding of Colchicine to tubulin (IC50 = 0.32 μM). This compound is valuable for studies investigating microtubule dynamics and their role in cellular processes, making it a useful tool in cancer research and the exploration of cytoskeletal modulation. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-30 is an effective inhibitor of tubulin polymerization, specifically targeting the colchicine binding site. By disrupting microtubule organization, it induces cell cycle arrest at the G2/M phase. This compound demonstrates significant antiproliferative activity against various cancer cell lines, including SGC-7901, A549, and HeLa, with respective IC50 values of 2.16, 2.21, and 0.403 μM, making it a valuable tool for cancer research applications. -
Tubulin Inhibitor
N-Deacetylthiocolchicine is a potent tubulin inhibitor with an IC50 value of 2.2 nM in multidrug-resistant MDA-MB 231 breast cancer cells. This compound exerts its antiproliferative effects by binding to tubulin, disrupting microtubule assembly, and causing cell cycle arrest during mitosis. N-Deacetylthiocolchicine is a valuable tool for investigating therapeutic strategies in malignancies, particularly breast cancer. -
Microtubule/Tubulin Inhibitor
Sudocetaxel is a microtubule depolymerization inhibitor that targets tubulin, impairing microtubule dynamics. This compound is particularly useful in drug delivery systems that are pH-sensitive, enhancing the therapeutic efficacy of docetaxel. It holds potential applications in cancer research, providing insights into microtubule-targeting therapies. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-21 is a potent tubulin polymerization inhibitor that disrupts microtubule assembly, leading to compromised cellular integrity. This compound demonstrates significant anti-cancer activity by interfering with glucose metabolism and cellular proliferation. It is suitable for research applications aimed at understanding cancer biology and the mechanisms of tubulin-targeting therapies. -
PLK-1/Tubulin Inhibitor
3,4,3'-Tri-O-methylflavellagic acid is a flavonoid compound that functions as an inhibitor of polo-like kinase-1 (PLK-1) and αβ-tubulin at the colchicine binding site. This compound disrupts microtubule assembly dynamics and modulates kinase activity, making it valuable for research into cancer cell proliferation and anti-nociceptive properties. Its unique biological activities make it a significant reagent for studies focused on cancer therapies and pain management. -
Tubulin Inhibitor
Tubulin-IN-52 is a potent tubulin inhibitor that exhibits notable cytotoxicity against various cancer cell lines, including prostate, lung, and ovarian cancers, with an impressive IC50 range of 0.9-3.8 mM in highly aggressive cancer models. This compound effectively inhibits the growth of established tumors while displaying minimal toxicity to normal cells. Tubulin-IN-52 serves as a valuable tool for investigating cancer biology and exploring potential therapeutic strategies in oncology research. -
Microtubule/Tubulin Control
CHM-1-P-Na is a sodium monophosphate salt of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one, targeting microtubule dynamics through tubulin interaction. This compound exhibits significant antitumor activity in both in vitro and in vivo models, demonstrating a distinct mechanism of action. CHM-1-P-Na offers promising applications in cancer research, particularly in studies focusing on tumor growth inhibition and the modulation of related enzymatic pathways. -
Tubulin Inhibitor
BKS3031A is a potent αβ-tubulin inhibitor that targets the colchicine binding site, effectively disrupting microtubule assembly dynamics. This compound demonstrates significant biological activity in modulating cellular processes such as mitosis and intracellular transport. BKS3031A is valuable for research applications in cancer biology and studies involving cytoskeletal dynamics. -
Microtubulin Inhibitor
Epothilone E is a microtubulin inhibitor that disrupts microtubule protein function, leading to the blockage of cell division. This compound exhibits significant anti-tumor activity and is valuable for research applications in cancer biology, particularly in studies focused on cell cycle regulation and mitotic progression. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-18 is a potent inhibitor of tubulin polymerization, targeting the microtubule dynamics essential for cellular structure and function. This compound exhibits significant anti-proliferative activity, making it valuable for research applications in breast cancer and chemoresistant colon cancer. Its ability to disrupt microtubule formation provides insights into the mechanisms of cancer cell growth and resistance, facilitating the development of new therapeutic strategies. -
Microtubule/Tubulin Inhibitor
Tubulin polymerization-IN-42 is an indole-substituted furanone that acts as a potent inhibitor of tubulin polymerization. Its primary mechanism targets microtubule dynamics, thereby interrupting the mitotic spindle formation. This compound exhibits significant anti-cancer activity, making it a valuable tool for research into cancer therapeutics and the study of microtubule-related cellular processes. -
Tubulin Polymerization Inhibitor
Tubulin Polymerization-IN-90 is a selective inhibitor of tubulin polymerization, targeting the nocodazole-binding site on β-tubulin. By disrupting microtubule formation, it induces the release of extracellular vesicles marked by CD63 and promotes IL-8 secretion from cells. This compound has demonstrated reduced viability in various cancer cell lines and is particularly relevant for research applications in acute T-lymphoblastic leukemia and other malignancies characterized by aberrant tubulin dynamics. -
Microtubule/Tubulin
Alestramustine is an antineoplastic cytostatic agent that primarily targets microtubules by binding to microtubule-associated proteins and β-tubulin via its active metabolites. This interaction disrupts microtubule function, leading to the inhibition of cell division. Alestramustine is utilized in research applications aimed at understanding cancer cell proliferation and the mechanisms of microtubule dynamics. -
Microtubule/Tubulin
Microtubule Inhibitor 7 targets tubulin, disrupting microtubule dynamics. This compound exhibits potent cytotoxic activity with IC50 values of 14.0 nM and 2.9 nM against the NCI-H460 human cancer cell line. It is valuable for research into cancer mechanisms and the evaluation of antiproliferative efficacy in various human cancer cell models. -
Microtubule/Tubulin Inhibitor
Dolastatinol is a synthetic analog of dolastatin 10 that acts as a potent inhibitor of tubulin polymerization. Its low nanomolar activity effectively disrupts microtubule formation, leading to significant effects on cell division and proliferation. This compound is valuable for research applications in cancer biology and studies investigating microtubule dynamics. -
Tubulin Inhibitor
J-30 is a potent tubulin inhibitor that selectively interferes with microtubule polymerization, demonstrating an IC50 of 15-20 nM. By inducing G2/M phase arrest, J-30 exhibits significant potential in the study of solid tumors, including gastric and oral cancers. This compound serves as a valuable tool for researchers investigating the mechanisms of cancer cell proliferation and progression. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-7 is an effective inhibitor of tubulin polymerization, disrupting microtubule dynamics. This compound demonstrates significant potential in cancer research by interfering with cellular division and tumor growth. It is a valuable tool for investigating mechanisms of tumorigenesis and evaluating therapeutic strategies targeting tubulin. -
Tubulin inhibitor
Tubulin inhibitor 16 is a potent compound targeting tubulin, effectively disrupting microtubule dynamics. It demonstrates significant antiproliferative activity and exhibits cytotoxic effects in HepG2 hepatic cancer cells. This reagent is valuable for research applications focusing on cancer cell biology and the mechanistic study of tubulin modulation. -
Tubulin Inhibitor
Tubulin Inhibitor 25 is a potent inhibitor of tubulin polymerization, with an IC50 value of 0.98 μM. It demonstrates significant activity against the HT29 cancer cell line, effectively inhibiting cell migration and tube formation, which are critical processes in angiogenesis. This compound is valuable for research applications related to cancer biology and investigations into anti-angiogenic therapies. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-50 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 of 5.05 μM in SK-Mel-28 cells. This compound effectively induces cell cycle arrest in the G2/M phase, making it a valuable tool for studying the mechanisms of cell division and tumor biology. Its application in research can aid in the development of novel therapeutic strategies targeting proliferative diseases. -
Microtubule/Tubulin Inhibitor
Ceratamine A is a microtubule/tubulin inhibitor derived from the marine sponge Pseudoceratina sp. This antimitotic heterocyclic alkaloid demonstrates significant cytotoxicity against various human cancer cell lines, making it a valuable tool for cancer research. Its ability to interfere with microtubule dynamics underscores its potential for studying cancer cell proliferation and treatment responses. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-57 is a potent tubulin polymerization inhibitor affecting microtubule dynamics. This α-naphthoxy-substituted carbendazim derivative induces mitotic arrest, effectively inhibiting proliferation in cancer cells. It demonstrates promising potential for research applications in cancer biology and therapeutic development. -
Microtubule/Tubulin Inhibitor
Tubulin Inhibitor 9 is a microtubule-targeting compound that selectively inhibits tubulin polymerization. Demonstrating potent anticancer activity, this compound achieves an IC50 of 0.9 nM in the MDA-MB 231 breast cancer cell line. It serves as a valuable tool for investigating microtubule dynamics and evaluating potential therapeutic strategies in cancer research. -
Microtubule/Tubulin Inhibitor
Cis-Trismethoxy resveratrol acts as a microtubule/tubulin inhibitor, demonstrating potent anti-mitotic properties. It effectively inhibits tubulin polymerization with an IC50 value of 4 μM. This compound is valuable for research applications focused on cell division, cancer biology, and the study of microtubule dynamics. -
Microtubule/Tubulin Inhibitor
2-Methylthiophenothiazine is a potent tubulin inhibitor known for its ability to disrupt microtubule dynamics. This compound has demonstrated potential anticancer activity by inhibiting tubulin aggregation, which may ultimately affect cell proliferation and survival. It is a valuable tool for research into cancer biology and for studies focusing on microtubule-targeting therapeutics. -
Tubulin polymerization Inhibitor
Tubulin polymerization-IN-74 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 value of 15 μM. This compound is utilized predominantly in anticancer research, providing valuable insights into microtubule dynamics and their role in cancer cell proliferation. Its inhibition of tubulin assembly makes it a valuable tool for studying pathways related to tumorigenesis and therapeutic strategies targeting cytoskeletal components. -
Tubulin Polymerization Inhibitor
Bifidenone is a potent inhibitor of tubulin polymerization, demonstrating significant antiproliferative effects across various human cancer cell lines. This compound's mechanism of action disrupts microtubule dynamics, making it a valuable tool for cancer research. Bifidenone is useful for investigating cellular processes related to mitosis and offers potential insights into therapeutic strategies targeting tumor cell proliferation. -
Tubulin Assembly Inhibitor
3,4',5-Trismethoxybenzophenone is a potent inhibitor of tubulin assembly, exhibiting an IC50 value of 2.6 µM. This compound disrupts microtubule polymerization, making it a valuable tool for studying cellular processes and the cytoskeleton. Its application ranges from investigating cancer biology to exploring mechanisms of drug resistance. -
Tubulin Inhibitor
NSC 145669 is a potent inhibitor of tubulin polymerization, demonstrating an IC50 of 1.7 μM. This compound exhibits significant cytotoxic effects on various cancer cell lines and has shown promising antileukemic activity in murine models. NSC 145669 serves as a valuable tool for research focused on cancer biology, particularly in the study of microtubule dynamics and therapeutic strategies targeting tubulin.
