Catalog No.
Product Name
Application
Product Information
Citations
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Nucleoside Antimetabolite/Analog Inhibitor
Netivudine is a nucleoside antimetabolite that acts as an analog inhibitor with significant antiviral activity against varicella zoster virus. In addition to its biological applications, Netivudine features an alkyne group, enabling its use in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc). This reagent is valuable for molecular biology research and chemical biology applications, particularly in the development of novel therapeutic agents. -
Topoisomerase II α/β Inhibitor
Chloroquinoxaline sulfonamide is a potent inhibitor of topoisomerase II α/β, disrupting the enzyme's function and causing DNA damage. This compound exhibits significant antitumor activity, making it a valuable tool for cancer research. Additionally, it is employed in veterinary medicine to control coccidiosis in various livestock, including poultry, rabbits, sheep, and cattle. Its varied applications underscore its importance in both therapeutic and research settings. -
Nucleoside Analogue
2-Fluoroadenosine is a nucleoside analogue targeting adenosine kinase (ADK). It exhibits significant antiparasitic activity, with an EC50 value of 0.842 mM against Cryptosporidium parvum. This compound serves as a valuable tool in the research of parasitic diseases, facilitating studies on metabolic pathways and therapeutic interventions. -
Purine Nucleoside Analog
7-Deazaguanosine is a purine nucleoside analog that exhibits antitrypanosomal activity. This compound targets the pathways involved in nucleotide metabolism, making it useful in the study of parasitic diseases such as Trypanosomiasis. Its biological activity aids in the exploration of nucleoside analogs for therapeutic applications in infectious diseases. -
Ns5b Polymerase Inhibitor
Anti-infective agent 10 is an NS5B polymerase inhibitor designed for research into hepatitis C virus (HCV) infections. This compound effectively disrupts the viral replication process, making it a valuable tool for studying HCV biology and developing antiviral therapies. Its applications extend to evaluating drug resistance mechanisms and supporting drug discovery efforts in combating HCV. -
Ns5b Polymerase Inhibitor
HCV NS5B polymerase-IN-2 is an inhibitor targeting the NS5B polymerase of the hepatitis C virus (HCV). This compound demonstrates significant antiviral activity against HCV replication, making it a valuable tool for the investigation of hepatitis C viral infections and the development of therapeutic strategies. Its efficacy in inhibiting NS5B polymerase highlights its potential role in studying HCV dynamics and drug resistance. -
HCV/HDAC6 Inhibitor
Nicoxamat, also known as N-Hydroxynicotinamide, functions as an inhibitor of hepatitis C virus (HCV) and selectively targets HDAC6. This compound exhibits antiviral activity against HCV, making it a useful tool in research on hepatitis C infection. Its role as an HDAC6 inhibitor further supports investigations into epigenetic regulation and potential therapeutic strategies. -
HCV NS5B Polymerase Inhibitor
BI 207524 is a selective non-nucleoside inhibitor of HCV NS5B polymerase, specifically targeting thumb pocket 1. This compound demonstrates antiviral activity against hepatitis C virus (HCV). BI 207524 is applicable in research focused on HCV infection and the mechanisms of antiviral response. -
HCV Polymerase Inhibitor
HCVP-IN-1 is a potent inhibitor of hepatitis C viral polymerase (HCVP). This compound effectively disrupts viral replication, making it a valuable tool for studying the dynamics of hepatitis C virus infection. HCVP-IN-1 is particularly relevant in research focused on developing antiviral therapies and understanding the mechanisms of HCV-related diseases. -
Nucleoside Analog
2'-Deoxy-2'-fluoroarabinoadenosine is a nucleoside analog that targets DNA synthesis. It demonstrates significant anticancer activity, particularly in the context of human immunodeficiency virus (HIV) research. This compound is valuable for studies involving nucleoside metabolism and the investigation of antiviral therapies. -
Anti-HIV-1 Nucleoside Analog
QYL-685 is an anti-HIV-1 nucleoside analog featuring a Z-methenylcyclopropane structure with 2,6-diaminopurine, demonstrating significant antiviral activity against HIV-1. This compound is effective against HIV-1 strains resistant to Zidovudine and Didanosine in vitro. QYL-685 serves as a valuable tool for researching HIV-1 infection and evaluating antiviral mechanisms. -
Oxathiolane Nucleoside Analog
rel-Emtricitabine is an oxathiolane nucleoside analog primarily targeting reverse transcriptase in HIV. It exhibits potent antiviral activity against HIV, making it an essential component of combination therapy for effectively managing HIV infections. This compound is valuable for research applications focused on HIV replication and therapeutic strategies. -
Nucleoside Analog
N6-Benzoyl-2'-deoxyadenosine monohydrate is a nucleoside analog that interacts with DNA duplexes, resulting in structural alterations. This modification can be utilized in the diagnosis of bacterial infections, with detection methods often employing electrophoresis. Its ability to bind to and perturb DNA structures makes it valuable for research in molecular biology and nucleic acid studies. -
Chikungunya Virus Polymerase Inhibitor
GAP-1173149 is a selective inhibitor of the Chikungunya virus (CHIKV) polymerase, specifically targeting the nsP4 RNA-dependent RNA polymerase. This compound demonstrates potent antiviral activity by hindering viral RNA replication, making it a valuable tool for studying CHIKV biology and developing antiviral strategies. Its application is particularly relevant in research focused on emerging viral threats and potential therapeutic interventions for Chikungunya virus infections. -
SIRT1 Inhibitor
SIRT1-IN-1 is a selective inhibitor of SIRT1, exhibiting an IC50 of 0.205 μM. In addition to its primary target, it also inhibits SIRT2 with an IC50 of 11.5 μM. This indole compound demonstrates antiviral activity, particularly against cytomegalovirus (CMV), making it a valuable tool for research into SIRT1-related pathways and antiviral applications. -
Viral DNA Polymerases Inhibitor
Cidofovir diphosphate is a potent inhibitor of viral DNA polymerases, primarily targeting human cytomegalovirus (HCMV), herpes simplex virus type 1 (HSV-1), and herpes simplex virus type 2 (HSV-2). With Ki values of 6.6 μM, 0.86 μM, and 1.4 μM for these polymers, respectively, it demonstrates selective antiviral activity. This compound is instrumental in research focusing on antiviral drug development and elucidating the mechanisms underlying viral DNA replication. -
Polymerase Inhibitor
T-1105 is a novel broad-spectrum viral polymerase inhibitor that acts by being converted into a ribonucleoside triphosphate (RTP) metabolite. This compound demonstrates antiviral activity against multiple RNA viruses by inhibiting their polymerases. T-1105 is particularly significant in studies aimed at understanding viral replication and developing antiviral strategies. Its mechanism of action highlights its potential applications in viral pathogenesis research and therapeutic interventions. -
SIRT Inhibitor
Nicotinamide hydrochloride is an inhibitor of SIRT1 and SIRT2, targeting the sirtuin family of proteins critical for cellular regulation. This reagent has been shown to enhance cellular levels of NAD+ and ATP while increasing reactive oxygen species (ROS) levels. Research applications include investigation into tumor growth inhibition and potential improvements in survival, as well as exploring its anti-hepatitis B virus (HBV) activity. -
HCV NS5B Polymerase Inhibitor
MB-11362 is a potent, orally active inhibitor of the hepatitis C virus (HCV) NS5B polymerase, functioning as a 4′-azidouridine triphosphate prodrug. Upon oral administration, MB-11362 is converted to its active form, 4′-azidouridine triphosphate, which effectively disrupts viral RNA synthesis. This compound is valuable for research focusing on HCV infection and understanding the mechanisms of antiviral therapies targeting RNA polymerases. -
Nucleoside Analog/Anti-HCV Agent
Valopicitabine dihydrochloride is a nucleoside analog that serves as the orally bioavailable prodrug of the potent anti-HCV agent 2'-C-methylcytidine. It functions by competitively inhibiting the NS5B polymerase, leading to chain termination and subsequent viral replication inhibition. This compound is primarily utilized in research related to Hepatitis C virus (HCV) treatment and antiviral drug development. -
HCV RNA Polymerase Inhibitor
BILB 1941 is a potent nonnucleoside inhibitor targeting the hepatitis C virus (HCV) RNA polymerase. It demonstrates significant antiviral activity in vitro, making it a valuable tool for research applications related to HCV replication and drug development strategies against hepatitis C. -
NS5B Polymerase Inhibitor
ABT-072 potassium trihydrate is a potent non-nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase. It demonstrates significant antiviral activity, exhibiting EC50 values of 1 nM against HCV genotype 1a and 0.3 nM against genotype 1b. This compound is primarily utilized in research focused on HCV replication and the development of antiviral therapies. -
Nucleoside Analog/Anti-HCV Agent
Valopicitabine is a nucleoside analog and an orally bioavailable prodrug of the potent anti-hepatitis C virus (HCV) agent 2'-C-methylcytidine. It selectively targets the NS5B polymerase, competitively inhibiting its activity and resulting in chain termination during viral RNA synthesis. Valopicitabine is primarily utilized in research focused on HCV infection and antiviral therapy development. -
HCV NS5B Polymerase Inhibitor
MK3281 is a non-nucleoside inhibitor targeting the hepatitis C virus (HCV) NS5B polymerase. It demonstrates significant antiviral activity, with an EC50 of 28 nM for genotype 1a. This compound is utilized in research focused on antiviral drug development and understanding HCV replication mechanisms. -
NS5B Polymerase Inhibitor
PSI-353661 is a purine nucleotide inhibitor targeting the NS5B polymerase of Hepatitis C Virus (HCV). It demonstrates potent antiviral activity with EC90 values of 8 nM for wild-type HCV and 11 nM for the S282T resistant strain. Additionally, PSI-353661 achieves elevated levels of its active triphosphate form in primary human hepatocytes, making it a valuable tool for studying HCV replication and resistance mechanisms. -
HCV NS5B Polymerase Inhibitor
HCV NS5B polymerase-IN-3 is a potent inhibitor of the hepatitis C virus (HCV) NS5B polymerase, demonstrating significant antiviral activity. In the Huh7 replicon cell line, it exhibits an EC50 value of 0.23 μM while maintaining a favorable cytotoxicity profile. This compound is relevant for research applications focused on HCV replication and drug development strategies targeting hepatitis C. -
HCV Polymerase Inhibitor
VCH-916 free base is a non-nucleoside inhibitor targeting the NS5B polymerase of Hepatitis C virus (HCV). This compound demonstrates potent antiviral activity, making it a valuable tool for research on HCV replication. It is primarily utilized in studies focused on developing effective treatments for Hepatitis C and understanding the viral mechanisms of polymerase function. -
DNA Gyrase/Topoisomerase IV Inhibitor
Topoisomerase Inhibitor 6 is a dual irreversible inhibitor targeting DNA gyrase and topoisomerase IV, demonstrating a minimum inhibitory concentration (MIC) of 0.06 μg/mL against fluoroquinolone-resistant Staphylococcus aureus. This compound functions by obstructing the DNA strand break-reunion process, thereby causing lethal DNA damage. It holds potential for the study of Gram-positive bacterial infections, including those caused by S. aureus and Streptococcus pneumoniae. -
Topoisomerase II Inhibitor
NBTI 5463 is an inhibitor of bacterial type II topoisomerases, specifically targeting topoisomerase II. This compound exhibits potent antibacterial activity by inhibiting GyrA and TopoIV in Pseudomonas aeruginosa and Escherichia coli. By binding to topoisomerase II, NBTI 5463 disrupts DNA cleavage and religation, thereby obstructing bacterial DNA replication and transcription. This compound holds promise for advancing research on Gram-negative bacterial infections. -
Topoisomerase II Inhibitor
(-)-BO 2367 is a potent topoisomerase II inhibitor, exhibiting significant antibacterial and antitumor properties. It demonstrates IC50 values of 3.8 μM against the DNA relaxation activity of L1210 topoisomerase II and 0.5 μM and 1 μM against the supercoiling activities of Escherichia coli and Micrococcus luteus gyrases, respectively. This compound is valuable for research applications in cancer biology and microbial resistance studies, facilitating further exploration of therapeutic interventions. -
DNA Topoisomerase IV Inhibitor
Topoisomerase IV inhibitor 1 is a selective inhibitor of DNA topoisomerase IV, exhibiting an IC50 value of 0.23 μM, which highlights its potent activity. It additionally demonstrates inhibitory effects on DNA gyrase with an IC50 of 0.43 μM. This compound showcases significant antibacterial properties, with minimum inhibitory concentrations (MICs) of 0.972 μM against Staphylococcus aureus Newman and 0.608 μM against Escherichia coli ATCC8739. It is ideal for research applications focused on bacterial topoisomerase mechanisms and the development of novel antimicrobial agents. -
Bacterial Topoisomerase Inhibitor
Topoisomerase Inhibitor 5 is a potent bacterial topoisomerase inhibitor, exhibiting a low inhibitory concentration of 0.125 µg/mL. This compound demonstrates significant antituberculous activity, making it valuable for the study of tuberculosis and related bacterial infections. Its mechanism of action primarily involves the disruption of DNA topology, which is essential for bacterial replication and survival. -
DNA Topoisomerase IV Inhibitor
Topoisomerase IV inhibitor 2 is a potent inhibitor of DNA topoisomerase IV, exhibiting IC50 values of 0.35 μM and 0.55 μM against topoisomerase IV and DNA gyrase, respectively. This compound demonstrates significant anti-bacterial activity, with minimum inhibitory concentrations (MICs) of 1.985 μM against Staphylococcus aureus Newman and 0.744 μM against Escherichia coli ATCC8739. It serves as a valuable tool for investigating bacterial topoisomerases and exploring novel antibacterial strategies in research applications. -
Topoisomerase II Inhibitor
TP0480066 is a selective inhibitor of topoisomerase II, demonstrating IC50 values of 1.10 nM and 62.89 nM for DNA gyrase and topoisomerase IV, respectively. This compound exhibits significant antibacterial activity against various bacterial species, including drug-resistant strains. Additionally, TP0480066 shows potent inhibitory effects against Neisseria gonorrhoeae, making it a valuable reagent for research focused on gonorrhea and related bacterial infections. -
Topoisomerase 1 Inhibitor
VIP236 is a potent topoisomerase 1 inhibitor that selectively targets αvβ3 integrin for tumor localization. Upon binding, VIP236 leverages its cleavable linker, which is activated by neutrophil elastase prevalent in the tumor microenvironment, to deliver 7-ethylcamptothecin directly to cancer cells. This payload induces DNA damage through topoisomerase 1 inhibition, resulting in significant anti-tumor effects. VIP236 has demonstrated a 10-fold increased tumor/plasma ratio compared to traditional treatments, inducing tumor regression and reducing metastasis in various preclinical models, including non-small cell lung cancer, triple-negative breast cancer, and other metastatic solid tumors. -
HDAC Inhibitor
CM-444 is a potent inhibitor of histone deacetylases (HDACs) with an IC50 range of 6 nM to 0.6 μM, and demonstrates inhibition of DNA methyltransferases (DNMT) with IC50 values between 1.8 and 2.3 μM. This compound facilitates the differentiation of acute myeloid leukemia cells and exhibits significant anti-leukemic activity, enhancing survival rates in mouse models. CM-444 serves as a valuable tool for research into cancer epigenetics and the development of targeted therapies for leukemia. -
CARM1/HDAC2 inhibitor
CARM1/HDAC2-IN-1 is a dual inhibitor targeting both CARM1 and HDAC2, exhibiting IC50 values of 3.71 nM and 4.07 nM, respectively. This compound demonstrates significant antitumor activity, making it a valuable tool for cancer research. CARM1/HDAC2-IN-1 is suitable for studies investigating the role of these epigenetic regulators in tumor biology and therapeutic strategies. -
Nucleoside Analog
3'-O-Azidomethyl-CTP is a nucleoside analog that serves as a crucial building block for nucleic acid synthesis. It exhibits versatility in the synthesis of modified RNA and DNA, making it valuable for applications in molecular biology and genetic engineering. This compound enables researchers to incorporate azidomethyl groups into nucleic acid structures, facilitating studies in genetic function, drug development, and bioconjugation techniques. -
Nucleoside Analog
DMTr-2'-O-propyl-rC(Bz)-3'-CE-phosphoramidite is a nucleoside analog designed for use in oligonucleotide synthesis. This monomer plays a critical role in the formation of modified RNA molecules, facilitating studies in molecular biology and gene therapy applications. Its unique structure enhances stability and incorporation efficiency, making it an invaluable tool for researchers exploring nucleic acid functionality and behavior. -
Nucleoside Analog
DMTr-S-5-C-Me-2'-O-Me-rA(Bz)-3'-CE-phosphoramidite is a nucleoside analog used primarily in the synthesis of modified oligonucleotides. This phosphoramidite allows for the incorporation of modified ribonucleotides, enhancing stability and binding affinity in nucleic acid constructs. It is valuable for applications in therapeutic research, molecular biology, and gene delivery systems. -
Nucleoside Analog
m7ITP is a nucleoside analog that serves as a key monomer for nucleic acid synthesis. This compound exhibits essential properties for the development of RNA and DNA constructs, enabling detailed studies in molecular biology and genetic engineering. Its utility includes applications in the design of synthetic oligonucleotides and investigation of nucleic acid interactions. -
Nucleoside Analog
DMTr-2'-O-Me-rA(Bz)-3'-(D)-PSM-phosphoramidite is a nucleoside analog designed for efficient nucleic acid synthesis. This compound serves as a key monomer for the incorporation of modified ribonucleotides into oligonucleotides, enhancing stability and bioactivity. It is particularly useful in the development of RNA therapeutics, probes, and various molecular biology applications, facilitating precise manipulation of RNA structures. -
Nucleoside Analog
5'-OH-(2'OMe-U)pU is a nucleoside analog designed for use in nucleic acid synthesis. This compound serves as a monomeric building block, facilitating the incorporation of modified RNA structures. Its specific properties make it suitable for applications in RNA research, including the development of oligonucleotides and experimental RNA technologies. -
Nucleoside Analog
DMTr-2'-O-propyl-rA(Bz)-3'-CE-phosphoramidite is a specialized nucleoside analog designed for RNA synthesis. This phosphoramidite derivative facilitates the incorporation of modified nucleotides into RNA strands, enhancing the stability and functionality of nucleic acids. Its applications include the development of RNA-based therapeutics, probes, and biosensors, making it a valuable tool in nucleic acid research and biotechnological studies. -
Nucleoside Analog
5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu) is a nucleoside analog specifically designed for use in nucleic acid synthesis. This compound functions as a protected monomer, facilitating the incorporation of modified guanosine units into oligonucleotide sequences. Its unique structural features enhance stability and enzymatic properties, making it an essential reagent for researchers focused on developing therapeutics and diagnostic tools involving RNA and DNA. -
Nucleoside Analog
2'-O-MOE-GTP is a nucleoside analog that serves as a substrate in the synthesis of oligonucleotides. Its unique substitution at the 2' position enhances the stability and binding affinity of RNA molecules. This compound is widely utilized in RNA research, including studies on RNA interference and the development of therapeutics targeting RNA-based diseases. -
Nucleoside Analog
Spacer C12 phosphoramidite is a nucleoside analog that serves as a building block for nucleic acid synthesis. This monomeric reagent enables the incorporation of spacer elements into oligonucleotide sequences, facilitating studies in molecular biology and genetics. Its unique structure allows for enhanced structural flexibility and potential applications in functionalized nucleic acids for research purposes. -
Nucleoside Analog
2',3'-Di-O-Methyladenosine is a nucleoside analog primarily utilized in nucleic acid synthesis. This compound serves as a valuable monomeric building block, facilitating the production of modified RNA and DNA. Its unique structural properties enhance the stability and functionality of nucleic acid constructs, making it an essential tool for researchers in molecular biology and genetic engineering applications. -
Nucleoside Analog
Cy3-CTP is a nucleoside analog that functions as a fluorescently labeled cytidine triphosphate. It is utilized in nucleic acid synthesis, allowing for the incorporation of Cy3 dye into RNA and DNA molecules. This compound is particularly beneficial for applications in molecular biology, including real-time PCR, in situ hybridization, and RNA imaging techniques, facilitating enhanced tracking and visualization of nucleic acids. -
Nucleoside Analog
2'-O-Propargyl-rC(Bz) is a nucleoside analog with a propargylic functionality that serves as a versatile monomer for nucleic acid synthesis. Its structure enables incorporation into RNA strands, facilitating the study of nucleic acid interactions and modifications. This compound is particularly useful in research applications involving RNA synthesis, bioconjugation, and the development of nucleic acid-based therapeutics.
