2’-O-Methyl-5-methyl-4-thiouridine

Catalog No.: A55976
Purine Nucleoside Analog
2’-O-Methyl-5-methyl-4-thiouridine is a purine nucleoside analogue that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological effects are attributed to mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable in cancer research for exploring therapeutic strategies and understanding the cellular processes involved in tumorigenesis.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
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Nature volume 551, pages639-643 (2017)
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Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description2’-O-Methyl-5-methyl-4-thiouridine is a purine nucleoside analogue that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological effects are attributed to mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable in cancer research for exploring therapeutic strategies and understanding the cellular processes involved in tumorigenesis.
Product Information
Catalog NumA55976
FormulaC11H16N2O5S
Molecular Weight288.32
CAS Number2095417-26-6
SMILESOC[C@@H]1[C@@H](O)[C@@H](OC)[C@H](N2C(NC(C(C)=C2)=S)=O)O1
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