Catalog No.
Product Name
Application
Product Information
Citations
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Adenosine Nucleoside
8-Methyladenosine is a modified adenosine nucleoside that exerts its effects through methylation at the 8-position. This modification imparts resistance to five classes of antibiotics that target the ribosomal peptidyl transferase center, making it a valuable tool in research on antibiotic-resistant bacterial infections. Its unique properties make it essential for understanding the mechanisms of resistance and developing strategies to counteract such infections. -
Nucleoside Antimetabolite/Analog
N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine is a nucleoside antimetabolite and analog that serves as a valuable intermediate for synthesizing oligodeoxynucleotides with 3'-S-phosphorothiolate linkages. This compound is instrumental in studying enzyme-catalyzed cleavage processes within DNA, aiding in the investigation of nucleic acid interactions and mechanisms. Its structural features enhance its utility in various genetic and molecular biology research applications. -
Purine Nucleoside Analog
N6-Ethyl-2’-deoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism includes the inhibition of DNA synthesis, which plays a crucial role in inducing apoptosis. This compound is valuable for research applications aimed at investigating cancer biology and developing therapeutic strategies for lymphoid malignancies. -
Purine Nucleoside Analog
5-Iodouridine is a purine nucleoside analog that primarily targets dihydroorotase, exhibiting an inhibition constant (Ki) of 340 µM. This compound has been shown to notably enhance the cytotoxic effects of gamma irradiation. Its applications in research extend to investigating herpes simplex virus type 1 (HSV-1) infection and leukemia, providing valuable insights into therapeutic mechanisms and potential treatment strategies. -
Nucleoside
L-Guanosine is a purine nucleoside that primarily targets nucleoside metabolism. It exhibits anti-herpesvirus activity, making it a valuable tool for studying viral infections. Additionally, L-Guanosine can be utilized in the preparation of supramolecular hydrogels, which have potential applications in drug delivery and tissue engineering. -
Uridine Analog
N3-Methyl-2’-O-methyluridine is a uridine analog that targets diverse biological processes. It has been investigated for its potential anticonvulsant and anxiolytic effects, contributing to research in neurological disorders. Additionally, this compound is valuable in the exploration of new antihypertensive agents, making it a versatile tool in chemical research. -
Purine Nucleoside Analog
2’-Chloro-N6-(3-methoxy)benzyl adenosine is a purine nucleoside analog that exerts its anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. This compound demonstrates significant biological activity against indolent lymphoid malignancies, making it a valuable tool in cancer research. Its mechanisms of action are beneficial for studies focusing on therapeutic strategies for various malignancies. -
Purine Nucleoside Analog
Adenosine-2-carboxamide is a purine nucleoside analog that primarily targets cellular proliferation pathways. It exhibits significant antitumor activity against indolent lymphoid malignancies through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable research tool for investigating cancer treatment strategies and understanding purine metabolism in cancer cells. -
Uridine Analog
6-Methyluridine is a uridine analogue that serves as an important tool in neurological research. Its structure allows for the exploration of potential antiepileptic effects, making it useful in studies focused on anticonvulsant and anxiolytic activities. Additionally, this compound may assist in the development of novel antihypertensive agents, contributing to advancements in treatments for hypertension. -
Wobble Modification in tRNA
Mnm5s2U is a wobble modification present in the anticodon of lysine and glutamate tRNAs. This compound plays a crucial role in stabilizing codon-anticodon pairing, thereby enhancing translation fidelity and efficiency. Mnm5s2U is essential for studying tRNA modifications and their impact on protein synthesis, making it a valuable reagent for research in molecular biology and genetics. -
Nucleotide Prodrug
Fostroxacitabine bralpamide is an orally active nucleotide prodrug that targets cancerous cells through the cytotoxic effects of Troxacitabine. Upon conversion within the body, it exhibits potent antitumor activity, making it a valuable tool for cancer research. Its application in studies focused on cancer metabolism and therapeutic efficacy positions it as a significant compound in the development of innovative cancer treatments. -
Purine Nucleoside Analog
9-(2-Deoxy-beta-D-ribofuranosyl)-6-methylpurine is a purine nucleoside analog that primarily targets nucleic acid synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, through mechanisms such as the inhibition of DNA synthesis and induction of apoptosis. It serves as a valuable tool for research into cancer therapeutics and the development of nucleoside-based treatments. -
Purine Nucleoside Analog
2’,3’-Dideoxy-3’-fluorocytidine is a purine nucleoside analogue that inhibits DNA synthesis, making it a valuable compound in cancer research. This reagent exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inducing apoptosis and interfering with cellular proliferation. Its application in preclinical studies supports investigations into novel therapeutic strategies for treating various cancers. -
Purine Nucleoside Analog
4',5'-Didehydro-5'-deoxyuridine is a purine nucleoside analog known for its significant antitumor activity against indolent lymphoid malignancies. Its mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound serves as a critical reagent for studies aimed at understanding cellular responses to nucleoside analogs and their potential therapeutic applications in oncology. -
Purine Nucleoside Analog
Dihydrodeoxyuridine (H2dUrd) is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its anticancer mechanisms primarily involve inhibition of DNA synthesis and the induction of apoptosis. H2dUrd is a valuable reagent for research focused on cancer biology and therapeutic developments targeting nucleoside metabolism. -
Pain Inhibitor
Brivoligide (AYX1) is a double-stranded, unprotected oligonucleotide composed of 23 base pairs, functioning as a pain inhibitor. It has demonstrated efficacy in reducing acute post-surgical pain through its ability to mimic the DNA sequence typically bound by the transcription factor EGR1 on chromosomes. This unique mechanism makes Brivoligide a valuable tool for research applications focused on pain management and therapeutic interventions in pain-related conditions. -
Purine Nucleoside Analog
5′-Azido-5′-deoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. As a versatile click chemistry reagent, 5′-Azido-5′-deoxyadenosine contains an azide group that readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds featuring DBCO or BCN moieties, making it suitable for various chemical biology applications. -
Adenosine Analog
3’-O-(2-Methoxyethyl)adenosine is an adenosine analog that primarily functions as a smooth muscle vasodilator. This compound has demonstrated potential in inhibiting cancer progression, making it a valuable tool for oncological research. Its properties enable the exploration of adenosine signaling pathways and may contribute to the development of novel therapeutic strategies in cardiovascular and cancer research. -
Guanosine Analog
8-Nitroguanosine is a guanosine analog that exerts immunostimulatory activity. It has been shown to induce type I interferons in various animal models, leading to notable antiviral effects. The biological activity of 8-Nitroguanosine is primarily mediated through the activation of Toll-like receptor 7 (TLR7), making it a valuable tool for research in antiviral response and immune modulation. -
Uridine Analog
4'-C-Azidouridine is a uridine analog that functions as a click chemistry reagent. It features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne, DBCO, or BCN-containing molecules. This compound is instrumental in the investigation of uridine's potential anticonvulsant and anxiolytic properties and may aid in the development of novel antihypertensive agents. Its unique reactivity and biological relevance make it a valuable tool for chemical biology research. -
Purine Nucleoside Analog
α-Cytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is utilized in studies focused on elucidating the molecular pathways underlying tumorigenesis and developing novel therapeutic strategies. -
Adenosine Analog
9-(β-D-Xylofuranosyl)adenine is an adenosine analog that primarily acts as a vasodilator by targeting adenosine receptors. This compound has demonstrated significant biological activity, including the inhibition of cancer progression. It is particularly useful for researchers exploring the mechanisms of vasodilation and the therapeutic potential of adenosine-related pathways in cancer biology. -
Purine Nucleoside Analog
2-Chloro-9-(beta-D-ribofuranosyl)purine functions as a purine nucleoside analog. It exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptosis. This compound is valuable for research applications focused on cancer treatment and the underlying mechanisms of nucleoside analogs in therapeutic contexts. -
Adenosine Analog
2'-Fluoro-2'-deoxy-ara-A(Bz)-3'-phosphoramidite is an adenosine analog that functions primarily as a smooth muscle vasodilator. This compound demonstrates significant biological activity by potentially inhibiting cancer progression. It is widely utilized in research focused on nucleoside metabolism, therapeutic development, and the exploration of adenosine pathways in various physiological and pathological contexts. -
Purine Nucleoside Analog
2’-Deoxy-5,N4-dimethylcytidine is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is useful for studying the molecular pathways involved in tumor cell proliferation and can aid in the development of targeted therapies. -
Dinucleotide Derivative
Cytidylyl-(3′,5′)-uridine is a dinucleotide derivative that plays a crucial role in nucleotide metabolism. It serves as an important component for the investigation of RNA synthesis and degradation pathways. This compound is utilized in various research applications, including studies on enzymatic activity and cellular signaling processes associated with nucleotide functions. -
Purine Nucleoside Analog
DMTr-TNA-G(O6-CONPh2)(N2Ac)-amidite is a modified purine nucleoside analog that plays a critical role in the field of cancer research. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptosis. It is a valuable reagent for studies focusing on anticancer mechanisms and the development of therapeutic strategies. -
Purine Nucleoside Analog
Alpha-Guanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include inhibition of DNA synthesis and induction of apoptosis in cancer cells, making it a valuable reagent for cancer research. This compound can aid in investigations focused on understanding nucleoside metabolism and the development of novel therapeutic strategies in oncology. -
Purine Nucleoside Analog
2’-Deoxy-N3-methylcytidine is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is utilized in various studies aimed at understanding its effects on cancer cell proliferation and survival pathways. -
Purine Nucleoside Analog
2-Amino-9-β-D-ribofuranosylpurine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is useful in biochemical research focusing on cancer therapeutics and the exploration of nucleoside analog mechanisms in tumor biology. -
Purine Nucleoside Analog
5-Methoxycarbonyl methyl uridine is a purine nucleoside analog that exhibits significant antitumor activity. It operates through mechanisms including the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for studying indolent lymphoid malignancies. This compound is utilized in cancer research to explore its potential therapeutic effects and understand the underlying molecular pathways. -
Purine Nucleoside Analog
N4-Methyl-2’-O-methyl-cytidine functions as a purine nucleoside analog with significant antitumor activity, particularly effective against indolent lymphoid malignancies. Its mechanism of action includes the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research and therapeutic development. This compound is suitable for studies exploring nucleoside analogs in cancer treatment strategies. -
Nucleoside Analogue
1,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-D-ribofuranose is a nucleoside analogue that acts as a structural mimic of ribonucleosides. This compound exhibits potential antiviral properties and can be utilized in research focused on nucleoside metabolism and the development of antiviral therapeutics. Its unique modifications provide valuable insights for studies involving nucleic acid synthesis and enzymatic interactions in cellular systems. -
Purine Nucleoside Analog
2-Thiothymidine is a purine nucleoside analog with significant antitumor activity specifically targeting indolent lymphoid malignancies. Its primary mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research. This reagent is suitable for studies focused on elucidating mechanisms of tumorigenesis and evaluating therapeutic strategies in lymphoid cancers. -
Thymidine Analog
5-Methyl-2'-O-methyl-uridine is a thymidine analog that exhibits insertional activity within replicated DNA. This modified nucleoside plays a significant role in cellular labeling and tracking of DNA synthesis processes. Naturally occurring in tRNA from rabbit liver, 5-Methyl-2'-O-methyl-uridine is valuable in various biochemical research applications, particularly in studies involving nucleic acid dynamics and cellular metabolism. -
Adenosine Analog
2'-O-Methyladenosine 5'-monophosphate triethylammonium is an adenosine analog that primarily targets adenosine receptors. It exhibits significant biological activity, functioning as a smooth muscle vasodilator while also demonstrating potential for inhibiting cancer progression. This compound is valuable for research applications focusing on cardiovascular studies and cancer biology. -
Purine Nucleoside Analog
Raluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological effects are primarily mediated through the inhibition of DNA synthesis, leading to cell cycle arrest and the induction of apoptosis. This agent serves as a valuable tool in cancer research, facilitating studies aimed at understanding tumor biology and developing novel therapeutic strategies. -
Oxidation Product of 5-Hydroxykynuramine
4,6-Dihydroxyquinoline is an oxidation product of 5-hydroxykynuramine, primarily known for its role in influencing biological pathways through redox reactions. This compound exhibits notable biological activity as an antioxidant, which can contribute to the understanding of oxidative stress in cellular systems. Its applications in research include studies on neuroprotection, inflammation, and potential therapeutic interventions for various neurodegenerative diseases. -
Nucleoside
L-Inosine is an L-configured purine nucleoside primarily involved in cellular metabolism as a product of adenosine catabolism. It exhibits anti-inflammatory, antinociceptive, immunomodulatory, and neuroprotective properties, making it a valuable tool in research. L-Inosine can be applied in studies of neurodegenerative diseases, immune response modulation, and pain management, providing insights into its therapeutic potential in various biological contexts. -
Purine Nucleoside Analog
5-(Aminomethyl)uridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications focused on cancer biology and therapeutic development. -
Purine Nucleoside Analog
2′-Bromo-2′-deoxyuridine is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its primary mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is commonly utilized in research aimed at understanding cancer biology and developing therapeutic strategies for lymphoid cancers. -
Purine Nucleoside Analog
2'-Deoxy-2'-fluoro-4-thiouridine is a purine nucleoside analogue that exhibits potent antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focused on cancer biology and the development of nucleoside-based therapeutics. -
Nucleoside Analog
DMT-OMe-rA(Bz) is a nucleoside analog that functions by mimicking natural nucleosides, thereby influencing nucleic acid metabolism. This compound exhibits key biological activities such as incorporating into RNA and potentially interfering with RNA polymerase activity. DMT-OMe-rA(Bz) is primarily utilized in research applications focusing on RNA synthesis, gene expression modulation, and the development of antiviral therapeutics. -
Nucleobase
9-Ethylguanine is a modified nucleobase that serves as a valuable tool for studying nucleobase interactions and DNA alterations. This compound is particularly useful in exploring the antitumor activity of organometallic complexes. Its role in cancer research may contribute to a deeper understanding of nucleotide behavior and potential therapeutic applications. -
Ricin toxin A-chain (RTA) Substrate
DNA-GAGA is a specific substrate for Ricin toxin A-chain (RTA), exhibiting a slow depurination rate. Upon interaction, RTA cleaves a single adenylate at the GAGA stem-loop region of eukaryotic 28S RNA, highlighting its role as a potent ribosome-inactivating toxin. This compound is valuable for studying the mechanisms of RNA targeting and the toxic effects of ricin in cellular models. -
Guanosine Nucleoside Derivative
N-Isobutyryl-2',3'-Acetyl-Guanosine is a guanosine nucleoside derivative that serves as a substrate or inhibitor for various enzymatic reactions involving RNA metabolism. This compound is significant in studies investigating nucleoside signaling pathways and the modulation of guanosine-related biological processes. Its use can facilitate research into therapeutic strategies for diseases related to nucleoside metabolism. -
Linker
UnyLinker 12 is a universal linker designed for the synthesis of oligoribonucleotides. It facilitates the conjugation of ribonucleotides, enabling researchers to construct diverse RNA sequences for various applications. Its versatility makes it an essential tool in nucleic acid chemistry, including the development of RNA therapeutics and molecular probes. -
Nucleotide Analog
2'-F-Ac-C (N-Acetyl-2′-deoxy-2′-fluorocytidine) is a nucleotide analog that serves as a building block for the synthesis of oligoribonucleotides. Its incorporation into nucleic acid sequences can modulate biological activity and enhance stability. This reagent is valuable for research in nucleic acid chemistry, gene expression studies, and therapeutic applications involving RNA interference and antisense oligonucleotides. -
Adenosine Analog
N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine 3'CE-phosphoramidite is an adenosine analog that serves as a key building block for the synthesis of modified nucleotides. This compound exhibits smooth muscle vasodilatory activity and demonstrates potential in inhibiting cancer progression. Its applications in research include the development of therapeutic agents targeting adenosine pathways and investigations into nucleic acid functionality. -
Uridine Analog
5'-O-DMTr-3'-O-methyl uridine-3'-CED-phosphoramidite is a uridine analog that serves as a key substrate for nucleic acid synthesis. This compound exhibits potential anticonvulsant and anxiolytic properties, making it useful for studies in epilepsy and anxiety disorders. Additionally, its unique structure supports research focused on the development of novel antihypertensive agents.
