DNA Damage

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  1. Purine Nucleoside Analog

    9-(2-O-Acetyl-3,5-di-O-benzoyl-β-D-xylofuranosyl)-6-chloro-9H-purine is a purine nucleoside analog with notable antitumor activity. This compound primarily targets indolent lymphoid malignancies, functioning through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. Its application in cancer research offers insights into therapeutic strategies against various malignancies, making it a valuable reagent for investigating purine metabolic pathways.
  2. Purine Nucleoside Analog

    5'-Deoxy-5'-N-(2-chloroethyl)amino thymidine is a purine nucleoside analog that exerts its biological effects through inhibition of DNA synthesis and induction of apoptosis. This compound demonstrates broad antitumor activity, particularly against indolent lymphoid malignancies. Research applications include investigating the molecular mechanisms of cancer cell proliferation and exploring novel therapeutic strategies in oncology.
  3. Purine Nucleoside Analog

    3'-Amino-3'-deoxy-5-methyl uridine is a purine nucleoside analog that exhibits significant anticancer and antiviral properties. Its mechanism of action includes the inhibition of DNA synthesis and the induction of apoptosis, making it effective against indolent lymphoid malignancies. This compound is suitable for research applications focusing on cancer therapy and the study of nucleoside metabolism in cellular processes.
  4. Uridine Analog

    2',5-Difluoro-2'-deoxy-1-arabinosyluracil is a uridine analog that primarily targets nucleoside metabolism. It exhibits potential antiepileptic effects, making it relevant for research into anticonvulsant and anxiolytic properties. Additionally, this compound may serve as a valuable tool in the development of novel antihypertensive agents, contributing to advancements in therapeutic strategies for various neurological and cardiovascular conditions.
  5. Adenosine Analog

    5′-O-[(4-Cyanophenyl)methyl]-2′,3′-O-(1-methylethylidene)adenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits vasodilatory properties and demonstrates potential in inhibiting cancer cell proliferation. It is a valuable tool in research exploring the effects of adenosine signaling in cardiovascular diseases and cancer therapy.
  6. Purine Nucleoside Analog

    2-Chloroinosine is a purine nucleoside analog that exerts significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is useful for studying the effects of purine metabolism and the therapeutic potential of nucleoside analogs in various malignancies.
  7. Purine Nucleoside Analog

    3'-beta-Azido-2',3'-dideoxyuridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. It functions primarily by inhibiting DNA synthesis and inducing apoptosis, thereby impeding cancer cell proliferation. This compound is useful in various research applications, including studies focused on cancer therapeutics and mechanisms of action of nucleoside analogs.
  8. Nucleoside Metabolite

    12(R)-HPETE is a nucleoside metabolite that plays a significant role in the biosynthesis of lipids and signaling molecules. It is known to modulate various biological pathways, influencing processes such as inflammation and cell proliferation. This compound serves as a valuable tool for researchers investigating lipid metabolism and its implications in disease states.
  9. Nucleoside Metabolite

    N-(2-Cyanoethyl)-L-glutamine is a nucleoside metabolite that acts as an important precursor in nucleotide biosynthesis. This compound can be utilized in metabolic studies to investigate the roles of nucleoside derivatives in cellular processes. Its relevance in research applications includes exploring pathways related to nucleotide metabolism and potential therapeutic implications in metabolic disorders.
  10. Purine Nucleoside Analog

    5'-Azido-5'-deoxy-2'-O-methyl-5-methyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as a versatile click chemistry reagent due to its azide functional group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that contain alkyne groups, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing molecules.
  11. Purine Nucleoside Analog

    N6-Furfuryl-2-aminoadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focused on exploring anticancer therapies and understanding the underlying mechanisms of tumor growth and progression.
  12. Purine Nucleoside Analog

    9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin is a purine nucleoside analog primarily known for its antitumor activity. This compound exerts its biological effects by inhibiting DNA synthesis and inducing apoptosis, making it relevant for the study of indolent lymphoid malignancies. Its unique structural modifications enhance its potential as a therapeutic agent in cancer research.
  13. Cytidine Analog

    5-Iodo-2'-O-methylcytidine is a cytidine nucleoside analog that inhibits DNA methyltransferases. This compound exhibits significant anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research. Its ability to modify epigenetic regulation provides insights into gene expression and cellular processes, supporting the exploration of novel therapeutic strategies.
  14. Adenosine Analog

    N4-Benzoyl-5'-O-DMT-2'-O-propargyl adenosine is an adenosine analog that acts primarily as a smooth muscle vasodilator. This compound has demonstrated potential in inhibiting cancer progression, making it valuable for various biological research applications. Its distinctive structural properties facilitate the study of adenosine receptor interactions and signaling pathways, contributing to the understanding of cardiovascular physiology and tumor biology.
  15. Purine Nucleoside Analog

    2-Cyanoadenosine is a purine nucleoside analog that primarily targets cellular pathways involved in DNA synthesis and apoptosis. It exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, making it a valuable compound for cancer research. Its ability to inhibit DNA synthesis contributes to its potential effectiveness in therapeutic applications for various malignancies.
  16. Purine Nucleoside Analog

    2-[(3-Pyridyl) pyrrolidin-1-yl]-2’-deoxyinosine is a purine nucleoside analog that exerts its effects primarily by inhibiting DNA synthesis and inducing apoptosis. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. It serves as a valuable tool for research applications focused on cancer biology and the development of novel therapeutic strategies.
  17. Cytidine Analog

    2'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride is a cytidine nucleoside analog that specifically inhibits DNA methyltransferases. This compound demonstrates significant anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research. Its unique structure provides insights into nucleoside function and paves the way for therapeutic applications in epigenetic modulation.
  18. Nucleoside Metabolite

    Bitocholate is a nucleoside metabolite involved in cellular metabolism. It plays a significant role in regulating nucleoside levels and may impact various biological pathways. Its applications in research include studies on nucleoside metabolism and the exploration of related therapeutic targets.
  19. Nucleoside Metabolite

    11(S)-HPODE is a nucleoside metabolite that plays a critical role in cellular signaling and metabolic regulation. This compound is known to exhibit significant biological activity by modulating lipid peroxidation and promoting inflammatory responses. It is utilized in research applications focused on oxidative stress, inflammation, and related diseases, providing valuable insights into cellular processes and potential therapeutic interventions.
  20. Nucleoside Metabolite

    2-(Dimethylamino)ethylphosphonic acid is a nucleoside metabolite that functions primarily as an intermediate in phosphate metabolism. This compound plays a crucial role in biochemical pathways associated with nucleotide synthesis and degradation. Its applications in research include studies on cellular signaling, metabolic regulation, and the effects of phosphonates in various biological systems.
  21. Purine Nucleoside Analog

    5’-Deoxy-5’-iodo-2’-O-methyl-5-methyluridine is a purine nucleoside analog that demonstrates significant antitumor activity against indolent lymphoid malignancies. Its anticancer effects primarily involve the inhibition of DNA synthesis and the induction of apoptotic pathways. This compound is valuable for research applications focused on cancer therapeutics and the mechanistic study of nucleoside analogs in oncology.
  22. Nucleoside Metabolite

    Formylisoglutamine is a nucleoside metabolite that plays a crucial role in cellular metabolism. It is involved in the regulation of purine and pyrimidine biosynthesis, influencing various biological processes. This compound has potential applications in research related to metabolic pathways and the study of nucleoside derivatives in cellular function.
  23. Nucleoside Metabolite

    (R)-2-Hydroxy-α-linolenic acid is a nucleoside metabolite that plays a crucial role in lipid metabolism. This compound is known to exhibit various biological activities, including anti-inflammatory effects and modulation of cellular signaling pathways. It is utilized in research applications related to lipid biochemistry and metabolic disorders, aiding in the understanding of physiological processes and potential therapeutic targets.
  24. Purine Nucleoside Analog

    3’-Deoxy-N6-ethyladenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic development. Additionally, this compound can be employed in various studies related to nucleoside metabolism and its effects on cell proliferation.
  25. Antiviral Agent

    Detiviciclovir is an antiviral nucleoside analogue that targets viral DNA synthesis. It exhibits potent activity against a range of viral infections by inhibiting the replication of viral genomes. This compound is useful in research applications focused on developing antiviral therapies and understanding viral replication mechanisms.
  26. Nucleoside Metabolite

    Acetyl adenylate (5'-Acetylphosphoadenosine) is a nucleoside metabolite that primarily functions as an intermediate in nucleotide metabolism. This compound plays a crucial role in cellular energy transfer and regulation of various biochemical pathways. Acetyl adenylate is often utilized in research applications involving nucleotide signaling and enzymatic assays, providing insights into metabolic processes and cellular functions.
  27. Nucleoside Metabolite

    2-Formylaminobenzaldehyde is a nucleoside metabolite that plays a significant role in biochemical processes. It exhibits key biological activities that are vital for studying nucleoside metabolism and related pathways. This compound is commonly utilized in research applications focused on enzymatic reactions and metabolic profiling in biological systems.
  28. Purine Nucleoside Analog

    2′-Deoxy-5-methylisocytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly in indolent lymphoid malignancies. Its mode of action includes the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This reagent can be utilized in studies aimed at understanding tumor biology and developing novel therapeutic strategies.
  29. Nucleoside Metabolite

    5'-Butyrylphosphoinosine is a nucleoside metabolite that plays a critical role in cellular signaling pathways. This compound acts as a key regulator in the synthesis and metabolism of inositol phosphate, impacting various biological processes including cell proliferation and differentiation. It is primarily used in biochemical and pharmacological research applications to study metabolic pathways and signal transduction mechanisms.
  30. Purine Nucleoside Analog

    2'-Deoxy-2'-fluoro-N3-[(pyrid-2-yl)methyl]-beta-D-arabinouridine is a purine nucleoside analog that interferes with DNA synthesis, leading to antitumor effects. This compound exhibits significant biological activity against indolent lymphoid malignancies, promoting apoptosis in affected cells. It serves as a valuable tool for cancer research, particularly in the exploration of new therapeutic strategies targeting lymphoid tumors.
  31. Purine Nucleoside Analog

    3-Deaza-4’-C-methyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the promotion of apoptosis in cancer cells. This compound is invaluable for research applications focused on cancer biology and therapeutic development.
  32. Uridine Analog

    3’-beta-C-Methyluridine is an uridine analog that serves as a valuable tool for studying its pharmacological potential in epilepsy. This compound may exhibit antiepileptic properties and can be utilized in research focused on anticonvulsant and anxiolytic activities. Additionally, it holds promise for the development of novel antihypertensive agents, making it relevant for various therapeutic applications.
  33. Purine Nucleoside Analog

    Rev 2’-O-MOE-G(iBu)-5’-amidite is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable in research applications aimed at understanding cancer biology and developing novel therapeutic strategies.
  34. Click Chemistry Reagent

    Pyrene phosphoramidite dU is a versatile click chemistry reagent that incorporates pyrene moieties into nucleic acids. This compound exhibits strong blue fluorescence upon incorporation into DNA, making it an effective tool for studying nucleic acid interactions and dynamics. Pyrene phosphoramidite dU is widely used in applications such as DNA labeling, imaging, and the development of fluorescent probes for biophysical studies.
  35. Purine Nucleoside Analog

    3'-Amino-3'-deoxycytidine is a purine nucleoside analog that primarily targets DNA synthesis inhibition. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, through mechanisms such as apoptosis induction and interruption of cellular replication processes. It is a valuable reagent for research applications focused on cancer biology and therapeutic development.
  36. Cytidine Analog

    5-(2-Hydroxyethyl)cytidine is a cytidine analog known for its ability to inhibit DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research and epigenetic studies. Its unique mechanism allows for the exploration of methylation patterns and their impact on gene expression in various biological contexts.
  37. Purine Nucleoside Analog

    2-Chloro-N6,N6-dimethyladenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to the induction of apoptosis in cancer cells. This reagent is valuable for research applications focused on cancer biology and therapeutic development.
  38. Nucleoside Metabolite

    L-4-Hydroxyglutamate semialdehyde is a derivative of L-glutamic 5-semialdehyde, featuring a hydroxyl group at the 4-position. This compound acts as a vital nucleoside metabolite in various biological systems, including yeast, mice, and humans. Its biological activity is closely linked to the metabolic pathways of arginine and proline, making it relevant for research into amino acid metabolism and related physiological processes.
  39. Nucleoside Metabolite

    5-Ureidoimidazole-4-carboxylic acid is a nucleoside metabolite that serves as a key intermediate in purine metabolism. This compound has been utilized in research to study its role in nucleotide synthesis and its potential implications in metabolic disorders. Its biological activity can provide insights into cellular processes and contribute to investigations of metabolic pathways.
  40. Purine Nucleoside Analog

    2',3'-Dideoxy-3'-fluorouridine is a purine nucleoside analog that primarily inhibits DNA synthesis. Its key biological activity includes inducing apoptosis, which contributes to its broad antitumor efficacy against indolent lymphoid malignancies. This compound is valuable for research applications targeting cancer therapeutics and exploring mechanisms of nucleoside metabolism in tumor cells.
  41. Nucleoside Metabolite

    N,N-Dihydroxy-L-tyrosine is a nucleoside metabolite that acts as a precursor in biochemical pathways. This compound is involved in the regulation of neurotransmitter synthesis and may influence metabolic processes related to phenolic compounds. Its biological activity makes it valuable for research in neurobiology and metabolic studies.
  42. Purine Nucleoside Analog

    5-Methylcyclocytidine hydrochloride is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is suitable for investigating cellular proliferation and apoptosis pathways in various cancer models.
  43. Purine Nucleoside Analog

    4'-α-C-Methylcytidine is a purine nucleoside analogue that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, which can lead to the induction of apoptosis in cancer cells. This compound is an important tool in cancer research, providing insights into therapeutic strategies and the molecular pathways underlying tumor progression.
  44. Nucleoside Metabolite

    2-Oxo-3-sulfinopropanoic acid, also known as β-Sulfinyl pyruvate, is a nucleoside metabolite resulting from the deamination of cysteine sulfinic acid. It is known to decomposed into pyruvate and sulfite, thus playing a significant role in metabolic pathways. This compound is valuable for researchers investigating sulfur amino acid metabolism and related biochemical processes.
  45. Cytidine Analog

    5-Fluoro-4’-C-methylcytidine is a cytidine nucleoside analog that functions as an inhibitor of DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research. Its ability to interfere with DNA methylation processes facilitates studies on epigenetic regulation and therapeutic strategies targeting methylation pathways.
  46. Purine Nucleoside Analog

    7-Cyano-7-deazaguanosine is a purine nucleoside analog that exhibits significant antitumor activity. This compound targets indolent lymphoid malignancies through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. Its application in cancer research facilitates the exploration of therapeutic strategies against various malignant cell types.
  47. Purine Nucleoside Analog

    2’-Beta-C-Ethynyl inosine is a purine nucleoside analog that exhibits significant anticancer activity, particularly against indolent lymphoid malignancies. Its primary mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. Additionally, 2’-Beta-C-Ethynyl inosine serves as a click chemistry reagent due to its alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating various bioconjugation applications.
  48. 5'-AMP Analogue

    5'-AMPS is an analogue of 5'-AMP that functions as a substrate and competitive inhibitor of enzymes that interact with 5'-AMP. This compound is utilized in research to explore the regulatory mechanisms of cellular signaling pathways involving AMP, as well as to study enzyme kinetics. Its unique properties make it a valuable tool for dissecting the roles of AMP-related metabolic processes in various biological systems.
  49. Uridine Analog

    3′,5′-Bis-O-(triphenylmethyl)uridine is a uridine analog targeting nucleotide metabolism. This compound demonstrates potential antiepileptic properties and is utilized in research to explore anticonvulsant and anxiolytic activities. Additionally, it serves as a valuable tool in the development of novel antihypertensive agents, making it relevant for various therapeutic studies.
  50. Purine Nucleoside Analog

    5′-Azido-2′,5′-dideoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity by targeting indolent lymphoid malignancies. Its primary mechanisms include inhibition of DNA synthesis and induction of apoptosis. This compound is also a valuable click chemistry reagent, featuring an azide group that allows for copper-catalyzed azide-alkyne cycloaddition reactions with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules featuring DBCO or BCN groups, making it suitable for various biochemical applications.

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