Catalog No.
Product Name
Application
Product Information
Citations
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Purine Nucleoside Analog
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-2-thiouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly in the context of indolent lymphoid malignancies. Its primary mechanisms include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This reagent is valuable for research applications in cancer therapy and the study of nucleoside metabolism. -
Microbial Metabolite
Beta-alanyl-L-arginine is an intestinal microbial metabolite that plays a significant role in neurotransmission. This compound has been identified as useful in the investigation of schizophrenia, providing insights into its potential metabolic pathways and relationship with gut-brain interactions. Researchers may explore its effects on neurochemical signaling, offering a novel avenue for understanding psychiatric disorders. -
Fatty Acid
8(Z),11(Z),14(Z)-Heptadecatrienoic acid, also known as Norlinolenic acid, is a fatty acid comprised of three double bonds. This compound is recognized for its potential bioactivity in modulating lipid metabolism and promoting anti-inflammatory pathways. It serves as a valuable reagent in biochemical research focusing on fatty acid metabolism, lipidomics, and the exploration of dietary fats' effects on health. -
Purine Nucleoside Analog
1-[6-(Diethoxyphosphinyl)-2-O-methyl-β-D-ribo-hexofuranosyl]uracil is a purine nucleoside analog known for its ability to inhibit DNA synthesis and induce apoptosis in cancer cells. This compound demonstrates broad antitumor activity, particularly against indolent lymphoid malignancies, making it a valuable tool in cancer research. It is useful for studies aimed at understanding mechanisms of action in cancer therapy and for exploring therapeutic pathways involving nucleoside analogs. -
Purine Nucleoside Analog
1-(β-D-Ribofuranosyl)-5-nitropyrine-2(1H)-one is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological efficacy is primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis in neoplastic cells. This compound is valuable in cancer research, providing insights into therapeutic strategies targeting purine metabolism and DNA replication pathways. -
Guanosine Analog
8-(Phenylmethoxy)guanosine is a guanosine analog that exhibits immunostimulatory activity. This compound has been shown to induce type I interferons in various animal models, thereby providing antiviral effects. The biological activity of this guanosine analog is closely linked to the activation of Toll-like receptor 7 (TLR7), making it a valuable tool for research into antiviral mechanisms and immune response modulation. -
Purine Nucleoside Analog
1-Methyl-2'-O-methylinosine is a purine nucleoside analog that exhibits broad antitumor activity. This compound primarily targets indolent lymphoid malignancies and functions by inhibiting DNA synthesis and inducing apoptosis. It serves as a valuable tool in cancer research, aiding in the exploration of therapeutic approaches to treat various malignancies. -
Purine Nucleoside Analog
3’-Deoxy-3’-fluoro-5-methoxyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, which can lead to the induction of apoptosis in cancer cells. This compound is valuable for research applications focused on cancer therapeutics and elucidating the molecular mechanisms underlying tumorigenesis. -
Purine Nucleoside Analog
3',5'-Di-O-benzoyl fialuridine is a purine nucleoside analog that exhibits potent antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to cell cycle arrest and subsequent induction of apoptosis. This compound is valuable for research into therapeutic strategies targeting malignancies and understanding nucleoside analog mechanisms in cancer treatment. -
Nucleoside Metabolite
2-Methoxy-estradiol-17beta 3-glucuronide is a nucleoside metabolite known for its role in estradiol metabolism. This compound exhibits potential anti-proliferative activity and may influence estrogen signaling pathways. It is primarily used in research related to estrogen-related cancers, reproductive biology, and the study of glucuronidation processes. -
Purine Nucleoside Analog
3’-O-Levulinyl-2’-deoxyadenosine is a purine nucleoside analog that serves as an effective agent in anticancer research. It possesses significant antitumor activity, particularly against indolent lymphoid malignancies, through mechanisms that include DNA synthesis inhibition and apoptosis induction. This compound is valuable for studies focused on cancer therapeutics and mechanisms of action in malignant cell lines. -
Purine Nucleoside Analog
2'-Bromo-2'-deoxy-5-methyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound can be utilized to explore therapeutic strategies and pathways associated with tumorigenesis and cellular proliferation. -
Carboxysterol
4α-Carboxy-stigmasta-7,24(24(1))-dien-3β-ol is a carboxysterol that functions primarily as a bioactive sterol molecule. This compound exhibits significant biological activities, influencing lipid metabolism and cellular signaling pathways. It has applications in research focused on cholesterol biosynthesis, cardiovascular health, and the modulation of sterol-related diseases. -
Purine Nucleoside Analog
5’(R)-C-Methyladenosine is a purine nucleoside analogue that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound serves as a useful reagent for studying the effects of nucleoside analogs in therapeutic contexts. -
Purine Nucleoside Analog
2-Chloro-3′-deoxyadenosine is a purine nucleoside analog that primarily targets DNA synthesis. It exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting cellular proliferation and inducing apoptosis. This compound serves as an important tool in cancer research, providing insights into therapeutic approaches for hematologic malignancies. -
Purine Nucleoside Analog
2′-Deoxy-6-thioinosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action includes the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is useful for investigating the pathways involved in tumor cell proliferation and survival. -
Purine Nucleoside Analog
8-Benzyloxy-3’-deoxy-3’-fluoroguanosine is a purine nucleoside analog that exerts notable antitumor activity against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research focused on oncological studies, particularly in understanding the pathways of cancer cell proliferation and response to nucleoside-based therapies. -
Guanosine Analog
N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine is a guanosine analog that primarily targets Toll-like receptor 7 (TLR7). This compound exhibits immunostimulatory activity and has been shown to induce type I interferons in various animal models, leading to antiviral effects. It serves as a valuable reagent for research applications focused on innate immunity and the modulation of antiviral responses. -
Purine Nucleoside Analog
3’-Deoxy-3’-α-C-methylguanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focused on cancer biology and therapeutic development targeting purine metabolism. -
Purine Nucleoside Analog
3’-Deoxy-5’-O-(4,4’-dimethoxytrityl)-3’-fluorouridine is a purine nucleoside analog with significant potential in cancer research. It exhibits broad antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptotic pathways. This compound can be utilized in studies focused on cancer therapeutics and the mechanisms underlying nucleoside analog efficacy in oncological contexts. -
Purine Nucleoside Analog
2'-Deoxy-2'-fluoro-N4-benzoyl-5-methylcytidine is a purine nucleoside analog that showcases significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to apoptosis in cancerous cells. This compound serves as an essential tool for research in oncology, aiding in the exploration of novel therapeutic strategies targeting nucleic acid synthesis pathways. -
Purine Nucleoside Analog
1,3-Dimethyl pseudouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable reagent for cancer research. This compound is utilized in studies aimed at understanding cancer therapies and developing new treatments targeting nucleoside pathways. -
Purine Nucleoside Analog
7,8-Dihydro-8-oxo-7-propargyl guanosine is a purine nucleoside analog known for its antitumor activity, particularly against indolent lymphoid malignancies. This compound exerts its anticancer effects through mechanisms such as DNA synthesis inhibition and apoptosis induction. Additionally, it serves as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating advanced bioconjugation applications. -
Purine Nucleoside Analog
6-Chloro-2-iodo-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine is a purine nucleoside analog that exerts significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, contributing to its potential as an effective therapeutic agent in cancer research. This compound can be utilized in studies investigating the molecular pathways of cancer progression and treatment efficacy. -
Thymidine Analog
2’-O-Acetyl-5’-O-benzoyl-3’-O-methyl-5-methyl uridine is a thymidine analog that targets DNA synthesis through insertional activity into replicated DNA. This compound can be effectively utilized for cellular labeling and the monitoring of DNA synthesis dynamics in various research applications. Its unique structural modifications enhance its utility in nucleic acid studies, making it a valuable tool for molecular biology and genetic research. -
Purine Nucleoside Analog
1,3'-Dimethylguanosine is a purine nucleoside analog that exhibits significant anticancer properties. This compound primarily targets indolent lymphoid malignancies through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. It serves as a valuable tool in cancer research and therapeutic development, contributing to the understanding of purine metabolism and its implications in tumorigenesis. -
Purine Nucleoside Analog
3,4-Dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxamide functions as a purine nucleoside analog. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological effects are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research and therapeutic development. -
Purine Nucleoside Analog
5’-Deoxy-5’-iodo-2’-O-(2-methoxyethyl)uridine is a purine nucleoside analog known for its antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis. This compound is useful in cancer research for investigating cellular responses to nucleoside analog treatment and exploring therapeutic strategies in hematological malignancies. -
Purine Nucleoside Analog
2'-Deoxy-2'-fluoroarabino inosine is a purine nucleoside analog that exhibits potent antitumor activity through its ability to inhibit DNA synthesis and induce apoptosis. This compound is particularly relevant in the investigation of indolent lymphoid malignancies. Its mechanism of action makes it a valuable tool in cancer research and therapeutic development. -
Pyrimidine Nucleoside Analog
4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog known for its ability to inhibit both DNA and RNA synthesis. This compound exhibits significant biological activity, making it a valuable tool in anticancer research, antiviral studies, and immunomodulation investigations. Its diverse applications in biochemical assays contribute to the understanding of nucleic acid metabolism and therapeutic development. -
Adenosine Analog
2-(4-Methylbenzyl)thioadenosine is an adenosine analog that primarily targets adenosine receptors. It is recognized for its vasodilatory effects on smooth muscle and demonstrates potential in inhibiting cancer progression. This compound serves as a valuable tool in researching adenosine receptor signaling, cardiovascular function, and cancer biology. -
Modified Adenosine Nucleotide
Adenosine 5′-O-(1-thiotriphosphate) is a modified adenosine nucleotide featuring a thiol substitution at the α-phosphate position. This compound serves as a potent analog of ATP, effectively participating in various biochemical assays and enzymatic reactions. It is widely utilized in studies exploring signal transduction pathways, nucleotide-binding proteins, and cellular energy metabolism. -
Cytidine Analog
2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine is a cytidine analog that targets DNA methyltransferases. By inhibiting these enzymes, this compound demonstrates potential anti-metabolic and anti-tumor activities, making it a valuable tool for epigenetic research. Its unique chemical structure allows for specific modifications in nucleoside studies and provides insight into cellular processes related to DNA methylation. -
Purine Nucleoside Analog
N1-Methyl-arabinoadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly in indolent lymphoid malignancies. Its primary biological mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound serves as a valuable tool for researchers investigating targeted therapies and mechanisms of action in cancer treatment. -
Purine Nucleoside Analog
4'-Methylguanosine is a purine nucleoside analogue that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable in research applications focused on understanding and targeting malignant lymphoproliferative disorders. -
Purine Nucleoside Analog
N4-Benzoyl-3’-deoxycytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound functions by inhibiting DNA synthesis and inducing apoptosis, making it a valuable tool in cancer research. Its biological properties offer potential for exploring therapeutic strategies in oncology and studying mechanisms of cell cycle regulation. -
Purine Nucleoside Analog
2′-Deoxy-8-(methylthio)adenosine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is utilized in various studies aimed at understanding the mechanisms of tumor growth and potential therapeutic interventions. -
Purine Nucleoside Analog
5-O-(tert-Butyldiphenylsilyl)-2,3-isopropylidene-D-ribonolactone is a purine nucleoside analog known for its antitumor properties. This compound exhibits significant biological activity by inhibiting DNA synthesis and inducing apoptosis, making it a valuable tool in the research of indolent lymphoid malignancies. Its application in cancer research enhances understanding of cellular mechanisms and therapeutic strategies. -
Purine Nucleoside Analog
8-Chloro-2'-beta-C-methyl inosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research. This reagent is utilized in studies focused on exploring novel therapeutic strategies for malignancies involving purine metabolism. -
Purine Nucleoside Analog
2’-Deoxy-2’-fluoro-N1-methyl inosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is suited for studies exploring the biochemical pathways of purine metabolism and the therapeutic potential of nucleoside analogs in oncology. -
Thymidine Analog
3'-O-(2-Methoxyethyl)-5-methyluridine functions as a thymidine analog, exhibiting incorporation into replicated DNA. This compound is utilized to label cells, providing insights into DNA synthesis and cellular proliferation. Its unique structure allows for potential applications in studies of nucleic acid metabolism and the exploration of DNA-related processes in various biological contexts. -
eIF4E Inhibitor
eIF4E-IN-1 is a potent inhibitor of the eIF4E protein, which plays a critical role in regulating protein synthesis and cell proliferation. This compound effectively targets and inhibits immunosuppressive components, including immune checkpoint proteins such as PD-1, PD-L1, LAG3, TIM3, and IDO. eIF4E-IN-1 demonstrates promising biological activity in the modulation of immune responses, making it a valuable tool for research applications in cancer and infectious disease therapies. -
Integrated Stress Response Modulator
PRXS571 is a potent modulator of the integrated stress response (ISR) in neurons. This compound enhances our understanding of the cellular mechanisms underlying stress adaptation, making it valuable for research into neurodegenerative diseases and other neurological conditions. PRXS571 can be utilized to investigate the role of ISR modulation in various biological processes and therapeutic applications. -
GCN2-targeting Agent
RAPT-37-Me is a selective GCN2 inhibitor that demonstrates potent activity with an IC50 of 0.002 μM for GCN2, alongside higher IC50 values of more than 10 μM for PERK, 4.40 μM for HRl, and 1.31 μM for PKR. This compound is valuable for research applications focused on the integrated stress response and its implications in various diseases, offering insights into GCN2-mediated signaling pathways. It is particularly relevant for studies investigating therapeutic interventions that modulate cellular stress responses. -
ISR Modulator
ISR Modulator-1 is a compound that targets the integrated stress response (ISR) pathway. It functions by modulating cellular responses to stressors, enhancing cell survival under adverse conditions. This reagent is valuable for research applications investigating the mechanisms of cellular stress, neurodegenerative diseases, and metabolic disorders. -
MNK1/MNK2 Inhibitor
HD202A is a selective dual inhibitor of MNK1 and MNK2, exhibiting IC50 values of 6.09 nM and 8.06 nM, respectively. This compound effectively inhibits the MNK-eIF4E signaling pathway, leading to downregulation of perilipin 2 and SCD1, while upregulating adipose triglyceride lipase and PPARγ coactivator 1α. HD202A enhances mitochondrial fatty acid oxidation, redox homeostasis, and demonstrates significant effects on metabolic health, including suppression of body weight gain, reduction in hepatic lipid accumulation, and improvement in glucose tolerance and insulin sensitivity. These properties make HD202A a valuable tool for researching metabolic dysfunction-associated steatotic liver disease. -
eIF4A Inhibitor
eIF4A-IN-1 is a selective inhibitor of eIF4A, a key protein involved in the regulation of mRNA translation. This compound effectively reduces protein synthesis in cancer cells by disrupting the initiation of translation, thereby providing a valuable tool for investigating tumor biology. eIF4A-IN-1 is applicable in studies focused on cancer therapeutics and understanding the mechanisms of tumorigenesis. -
eIF4A Inhibitor
eIF4A3-IN-5 is a potent inhibitor of eukaryotic initiation factor 4A (eIF4A), specifically targeting eIF4AI and eIF4AII. This compound demonstrates significant potential for investigating eIF4A-dependent diseases, particularly in the context of cancer research. Its ability to modulate eIF4A activity makes it a valuable tool for studying mechanisms of protein synthesis and their implications in tumorigenesis. -
ISR Activator
ISR Activator 3 (Compound cc81) is a potent activator of the integrated stress response (ISR), targeting RIG-I with a dissociation constant of approximately 0.55 μM. This compound enhances the interferon response in the presence of viral mimicry signals while not inducing lipid droplet clearance. ISR Activator 3 is suitable for research related to neurodegenerative diseases and immune stress mechanisms, providing valuable insights into cellular stress pathways and their implications in various biological contexts. -
Promoter
NVS2.1 is a potent, orally bioavailable readthrough promoter that targets ribosome-associated quality control mechanisms. By promoting the degradation of eRF1, NVS2.1 activates pathways involving GCN1, RNF14, and RNF25, enabling the translation process to bypass premature termination codons. This compound is valuable for research focused on genetic disorders resulting from nonsense mutations.
