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2'-F T Amidite

Nucleoside Analog

2'-F T Amidite (DMTr-2'-F-dT-3'-CE-phosphoramidite) serves as a nucleoside analog in oligonucleotide synthesis. Its incorporation into nucleic acid sequences enhances thermal stability and binding affinity due to the fluorine substitution at the 2' position. This reagent is critical for studies involving RNA stability, gene expression modulation, and the development of antisense oligonucleotides.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	182700-06-7
Applications	Nucleoside Analog
Formula	C₄₀H₄₈FN₄O₈P
Molecular Weight	762.80
Synonyms	DMTr-2'-F-dT-3'-CE-phosphoramidite
SMILES	COC(C=C1)=CC=C1C(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)OC[C@H]4O[C@@H](N5C=C(C)C(NC5=O)=O)[C@H](F)[C@@H]4OP(OCCC#N)N(C(C)C)C(C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.