Catalog No.
Product Name
Application
Product Information
Citations
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glucocorticoid
Fluorometholone is a glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. -
glucocorticoid receptor agonist
Beclometasone, also known as Beclomethasone, is an anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma. - Flurandrenolide is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Flurandrenolide exerts its effects by interacting with specific cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression.
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glucocorticoid receptor agonist
Dexamethasone palmitate (DXP) is a prodrug of Dexamethasone, which is a glucocorticoid receptor agonist. Dexamethasone palmitate (DXP) has a 47-fold lower affinity for the glucocorticoid receptor than Dexamethasone. Anti-inflammatory agent. -
glucocorticoid receptor agonist
Dexamethasone acetate (Dexamethasone 21-acetate) is a glucocorticoid receptor agonist. -
synthetic glucocorticoid receptor agonist
Methylprednisolone succinate is a synthetic glucocorticoid and widely used as an anti-inflammatory agent. -
dissociated glucocorticoid receptor agonist
Fosdagrocorat (PF-04171327) is a dissociated glucocorticoid receptor agonist. -
glucocorticoid receptor agonist
Dagrocorat (PF-00251802) is a novel and dissociated glucocorticoid receptor agonist. - Betamethasone (hydrochloride) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
- Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. Desisobutyryl-ciclesonide has affinity for the glucocorticoid receptor.
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glucocorticoid receptor modulator
AZD7594 is a potent selective nonsteroidal glucocorticoid receptor modulator, with an IC50 of 0.9 nM. -
Glucocorticoid receptor (GR) antagonist
Exicorilant (CORT 125281) is a selective and oral active glucocorticoid receptor (GR) antagonist, with a Ki value of 7 nM. Exicorilant (CORT 125281) has potential to overcome adiposity, glucose intolerance and dyslipidaemia. -
glucocorticoid
Betamethasone acibutate, derives from Betamethasone, is an acetate ester. Betamethasone acibutate is a glucocorticoid. -
LXRα inhibitor
(20S)-Protopanaxatriol is a metabolite of ginsenoside, works through the glucocorticoid receptor (GR) and oestrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects. -
Glucocorticoid Receptor Agonist
Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities. - Betamethasone valerate is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
- Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.
- Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
- Flunisolide is a corticosteroid often used to treat allergic rhinitis.The principal mechanism of action of Flunisolide is to activate glucocorticoid receptors, meaning it has an anti-inflammatory action.
- Meprednisone is a glucocorticoid and a methylated derivative of prednisone
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synthetic glucocorticoid receptor agonist
Methylprednisolone is an apoptosis inducer and was also found to inhibit human small cell lung cancer cell growth in vitro. - Prednisolone is a glucocorticoid with the general properties of the corticosteroids.
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Glucocorticoid Receptor agonist
Prednisone reduces mucosal TNF-a production, intestinal permeability and levels of NF-kB expression. -
GR/IL-6 Inhibitor
Glucocorticoid receptor/IL-6-IN-1 is a selective dual inhibitor that targets both the glucocorticoid receptor (GR) and the IL-6 signaling pathway, demonstrating IC50 values of 120 nM and 59 nM, respectively. This compound effectively inhibits IL-6-induced phosphorylation of JAK/STAT3, thereby blocking the transcription of inflammatory cytokines. Glucocorticoid receptor/IL-6-IN-1 is a valuable tool for investigating inflammatory diseases, including rheumatoid arthritis and asthma. -
Mineralocorticoid/Glucocorticoid Receptor Agonist
Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. It exhibits significant anti-inflammatory properties by suppressing pro-inflammatory cytokine expression, including CCL2, IL-6, and IL-8 levels, while enhancing renal sodium and water transport, which contributes to increased plasma volume and blood pressure. Additionally, fludrocortisone induces key signaling pathways such as PI3K/Akt, mTOR, and ERK1/2, and is utilized in research applications related to congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency. -
Glucocorticoid Receptor Activator
Flunisolide hemihydrate is an orally active glucocorticoid receptor activator with potent anti-inflammatory properties. It induces eosinophil apoptosis, making it a valuable tool for researchers investigating asthma, rhinitis, and various inflammatory conditions. Its mechanism of action supports studies focused on the modulation of inflammatory pathways and the therapeutic applications of corticosteroids in respiratory diseases. -
Stable Isotope
Dexamethasone-4,6α,21,21-d4 is a deuterated derivative of Dexamethasone, functioning as a glucocorticoid receptor agonist. It exhibits potent anti-inflammatory properties, including the modulation of neutrophil and monocyte surface markers such as CD11b and CD18, which are crucial for immune cell activation and migration. This reagent is particularly relevant for research on inflammatory responses, including studies related to COVID-19, as well as investigations into exosome-mediated microRNA regulation in macrophage activation. -
Stable Isotope
Dexamethasone-d5 is a deuterium-labeled analog of the glucocorticoid receptor agonist Dexamethasone. It is known to reduce the expression of CD11b, CD18, and CD62L on neutrophils, as well as CD11b and CD18 on monocytes, thereby modulating immune responses. This stable isotope is particularly valuable in research applications studying the mechanics of inflammation, including the regulation of exosomal microRNA-155 production in lipopolysaccharide-stimulated macrophages, and its efficacy in managing conditions such as COVID-19. -
Stable Isotope
Dexamethasone-d4 is a deuterium-labeled derivative of Dexamethasone, which acts as a potent glucocorticoid receptor agonist. This compound has notable biological activities, including the modulation of immune cell marker expression by decreasing levels of CD11b, CD18, and CD62L on neutrophils, as well as CD11b and CD18 on monocytes. Dexamethasone-d4 is particularly valuable for research applications related to anti-inflammatory responses and the investigation of COVID-19 pathophysiology, as it inhibits exosome production containing inflammatory microRNA-155 during macrophage activation. -
Glucocorticoid Agonist
BI 653048 is a selective, orally active nonsteroidal glucocorticoid agonist, targeting the glucocorticoid receptor with an IC50 of 55 nM. It inhibits CYP enzyme isoforms including CYP1A2, CYP2D6, CYP2C9, CYP2C19, and CYP3A4, while exhibiting a reduced affinity for the hERG ion channel (IC50 > 30 μM). Additionally, BI 653048 serves as an HCV NS3 protease inhibitor, demonstrating potential for reducing viral loads in hepatitis C virus infections. This compound is valuable in studies related to glucocorticoid signaling and antiviral research. -
Stable Isotope
Fluticasone propionate-d5 is a deuterium-labeled derivative of fluticasone propionate, a potent topical anti-inflammatory corticosteroid. This compound selectively binds to the glucocorticoid receptor, exhibiting an absolute affinity (KD) of 0.5 nM, and demonstrates minimal interaction with other steroid receptors. It is primarily utilized in research involving anti-inflammatory and potential antiviral activities, making it a valuable reagent for studies focused on corticosteroid receptor mechanism and function. -
Dexamethasone-Glucocorticoid Receptor Inhibitor
Collismycin B is a potent inhibitor of the dexamethasone-glucocorticoid receptor, exhibiting an IC50 value of 10 µM. This compound demonstrates notable antimicrobial activity, making it a valuable tool for research in microbial pathogenesis. Additionally, Collismycin B exhibits cytotoxic properties, offering potential applications in cancer research and therapeutic development. -
Metabolite of Hydrocortisone
20β-Dihydrocortisol is a metabolite of Hydrocortisone that acts as a weak endogenous agonist of the glucocorticoid receptor (GR). This compound is generated from Hydrocortisone through the action of carbonyl reductase 1 (CBR1) in an NADPH-dependent process. Its unique properties make 20β-Dihydrocortisol valuable for investigating metabolic disorders such as obesity and its impact on glucocorticoid signaling pathways. -
Glucocorticoid Receptor Antagonist
CP-394531 is a highly selective non-steroidal antagonist of the glucocorticoid receptor (GR), exhibiting a Ki value of 0.1 nM. It demonstrates minimal binding to the androgen receptor (AR) (Ki = 130 nM) and negligible effects on the progesterone receptor and estrogen receptors (ERα, ERβ). CP-394531 effectively inhibits the agonistic effects of Dexamethasone with a Kif of 4.1 nM. This compound is valuable for researching a variety of conditions, including diabetes, obesity, depression, neurodegenerative disorders, glaucoma, and Cushing's disease. -
Glucocorticoid Steroid Hormone
Cortodoxone, a glucocorticoid steroid hormone, primarily functions as a glucocorticoid antagonist. It enhances tryptophan oxygenase (TO) activity and promotes the secretion of corticosterone. This compound is significant in research focused on T cell proliferation and activation, providing insights into immune response regulation. -
Glucocorticoid
Hydrocortisone hemisuccinate sodium is a potent glucocorticoid that exhibits significant anti-inflammatory properties by inhibiting proinflammatory cytokines, with IC50 values of 6.7 μM for IL-6 and 21.4 μM for IL-3. This compound is useful for research applications related to ulcerative colitis (UC), enabling the investigation of the underlying mechanisms of inflammation and potential therapeutic interventions. -
Nasal Spray
Fluticasone furoate is a synthetic trifluorinated corticosteroid that targets the glucocorticoid receptor with a high affinity (Kd of 0.3 nM). It exhibits significant anti-inflammatory and anti-asthmatic properties while maintaining low systemic exposure. This compound is primarily utilized in the treatment of allergic rhinitis, providing effective relief from nasal inflammation and associated symptoms. -
Anti-Inflammatory Agent
Methylprednisolone aceponate is a glucocorticoid with a specific mechanism of action as a selective glucocorticoid receptor ligand, primarily functioning as an anti-inflammatory agent. It exhibits weak systemic effects, making it particularly useful in the treatment of localized inflammatory conditions. This compound is valuable for research applications targeting eczema and other inflammatory skin disorders, aiding in the understanding of their pathophysiology and potential treatments. -
Glucocorticoid Receptor Antagonist
Cort108297 is a selective glucocorticoid receptor (GR) antagonist with a high affinity, exhibiting a Ki value of 0.45 nM. This compound effectively modulates GR signaling pathways, making it a valuable tool for elucidating the role of glucocorticoids in various biological processes. Research applications may include studies on inflammation, metabolic regulation, and stress response mechanisms. -
Glucocorticoid Metabolism Marker
Tetrahydrocortisone is a corticosteroid and a crucial marker for glucocorticoid metabolism, formed from endogenous glucocorticoids via the enzyme AKR1D1 (5β-reductase). This compound plays a vital role in maintaining glucocorticoid metabolic homeostasis and is regulated by the glucocorticoid receptor (GR). Tetrahydrocortisone is valuable for mechanistic investigations of metabolic diseases, including non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes, and serves as a reliable biomarker for assessing AKR1D1 activity and glucocorticoid metabolic status in vivo. -
Corticosteroid
Fluocinolone is a potent corticosteroid that primarily targets the inflammatory response in tissues. It exhibits strong anti-inflammatory and immunosuppressive activities, making it effective in alleviating symptoms such as redness, itching, and swelling associated with various dermatological disorders. Fluocinolone is commonly utilized in research applications focused on skin inflammation and corticosteroid therapy. -
Smo Agonist
Fluticasone is a synthetic corticosteroid that acts as an agonist of the Smoothened (Smo) receptor, with an IC50 value of 99 nM. This compound activates Hedgehog signaling pathways, promoting the proliferation of primary neuronal stem or precursor cells. Fluticasone is utilized in respiratory research and can provide insights into mechanisms related to cell growth and differentiation within the context of Hedgehog signaling. -
GR Agonist
GSK9027 is a non-steroidal agonist of the glucocorticoid receptor (GR), exhibiting partial agonistic activity on the 2×glucocorticoid response element (GRE) reporter system. This compound demonstrates intrinsic activities comparable to dexamethasone, making it a valuable tool for investigating GR-mediated signaling pathways. GSK9027 can be utilized in research applications focused on inflammation, immune response modulation, and drug development related to glucocorticoid therapies. -
Stable Isotope
Cortisone-d8 is a deuterium-labeled derivative of cortisone, a biologically active metabolite of cortisol and a member of the glucocorticoid class. This stable isotope is utilized in metabolic studies and has applications in pharmacokinetic research and the characterization of glucocorticoid receptor interactions. Cortisone exhibits immunosuppressive and anti-inflammatory properties, contributing to its role in a variety of therapeutic applications.
