Catalog No.
Product Name
Application
Product Information
Citations
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Glucocorticoid Receptor Agonist
ZK 216348 is a selective nonsteroidal glucocorticoid receptor agonist, exhibiting an IC50 of 20.3 nM. This compound also interacts with progesterone and mineralocorticoid receptors, with IC50 values of 20.4 nM and 79.9 nM, respectively. ZK 216348 demonstrates significant anti-inflammatory properties comparable to those of Prednisolone while minimizing transactivation-related side effects, making it a valuable tool for research in inflammation and related conditions. -
Drug Metabolite
Beclomethasone 17-propionate is a potent glucocorticoid receptor (GR) agonist and an active metabolite of Beclomethasone dipropionate. It demonstrates a higher affinity for the GR, making it more effective in modulating glucocorticoid activity. This compound effectively suppresses cytokine production in lung macrophages associated with chronic obstructive pulmonary disease (COPD), making it valuable for research in inflammation and respiratory disorders. -
Glucocorticoid
Tetrahydrocorticosterone is a glucocorticoid that functions primarily through binding to the glucocorticoid receptor (GR), thus modulating inflammatory responses. It plays a crucial role in the regulation of carbohydrate, protein, and fat metabolism. This compound is naturally produced by the adrenal glands and is extensively utilized in research focusing on inflammation, metabolic disorders, and endocrine function. Its diverse biological activities make it a valuable reagent for studying glucocorticoid signaling pathways and their implications in various physiological and pathological conditions. -
Glucocorticoid
Clobetasone butyrate is a synthetic glucocorticoid that modulates inflammation primarily through its action on glucocorticoid receptors. It exhibits potent topical anti-inflammatory activity, making it effective for treating corticosteroid-responsive dermatoses such as atopic dermatitis and psoriasis. This compound is useful for research focused on skin inflammation and therapeutic approaches to dermatological conditions. -
GR Modulator
Dazucorilant is a selective and high-affinity non-steroidal modulator of the glucocorticoid receptor (GR), demonstrating a Ki value of less than 1 nM in vitro. This compound is primarily utilized in research focused on neurological disorders, offering a valuable tool to investigate GR-related mechanisms and therapeutic potentials in conditions influenced by glucocorticoid signaling. -
Inhaled Glucocorticoid
Mometasone is an inhaled glucocorticoid that primarily targets the glucocorticoid receptor, exerting anti-inflammatory effects. It is effective in managing mild asthma, particularly in patients exhibiting low sputum eosinophil levels. Additionally, mometasone is valuable in research applications related to chronic hand eczema and rhinosinusitis, providing insights into inflammatory processes and treatment strategies. -
Glucocorticoid
Dexamethasone 9,11-epoxide is a glucocorticoid compound that functions primarily as a drug intermediate in the synthesis of dexamethasone and betamethasone. This reagent is significant for research applications focused on inflammation and immune diseases, offering insights into therapeutic development and mechanisms of action within glucocorticoid pathways. Its role in the assembly of corticosteroid medications makes it a valuable asset for studying anti-inflammatory responses. -
Stable Isotope
Budesonide-d8 is a deuterium-labeled analog of Budesonide, which acts primarily as a glucocorticoid receptor agonist. This compound exhibits anti-inflammatory properties essential for the management of asthma and has been shown to reduce lung tumor size, reverse DNA hypomethylation, and modulate mRNA expression of various genes. Budesonide-d8 serves as a valuable tool in pharmacokinetic and metabolic research, providing insights into the pharmacological effects and mechanisms of Budesonide in vivo. -
Androgen Receptor/glucocorticoid Receptor Inhibitor
GA32 is a dual inhibitor of the androgen receptor (AR) and glucocorticoid receptor (GR), exhibiting IC50 values of 0.13 μM for AR and 0.83 μM for GR. This compound effectively inhibits the proliferation of castration-resistant prostate cancer cells that exhibit resistance to Enzalutamide, demonstrating its potential in both in vitro and in vivo research applications. GA32 serves as a valuable tool for studies focused on targeting AR and GR pathways in cancer biology. -
Corticosteroid
Halobetasol is a potent corticosteroid that exerts anti-inflammatory effects by modulating immune responses and inhibiting the release of inflammatory mediators. This compound is primarily utilized in research related to severe localized psoriasis, helping to elucidate its pathophysiology and potential therapeutic strategies. Its efficacy in reducing psoriatic lesions positions Halobetasol as an important tool in dermatological studies and treatment development. -
Corticosteroid Agent
Prednicarbate is a topical corticosteroid agent that primarily targets inflammation in dermatological conditions. It exhibits potent anti-inflammatory properties, making it suitable for investigating inflammatory skin diseases, including atopic dermatitis. This compound aids in understanding the molecular mechanisms of corticosteroid action in skin treatments and can facilitate research into new therapeutic strategies for managing skin inflammation. -
Glucocorticoid Corticosteroid
Flumethasone pivalate is a glucocorticoid corticosteroid known for its anti-inflammatory, antipruritic, and vasoconstrictive properties. It acts by modulating gene expression involved in inflammation and immune responses, making it useful in the treatment of various dermatological conditions. This compound is particularly relevant for research applications focused on inflammation, immune modulation, and skin-related therapies. -
Anticoagulant Rodenticide
Flocoumafen is an orally active vitamin K epoxide reductase inhibitor that functions primarily as an anticoagulant rodenticide. Its mechanism involves a prolonged inhibition of blood coagulation, leading to effective rodent control. In addition to its primary target, Flocoumafen interacts with several other proteins, including prostaglandin F synthase and the glucocorticoid receptor 2. This second-generation anticoagulant displays a half-life of 177.4 hours, contributing to its lethal efficacy against rodent populations. -
Glucocorticoid Receptor Agonist
GSK866, also known as (S)-GSK47866A, is a selective agonist of the glucocorticoid receptor, exhibiting an IC50 of 4.6 nM. This compound is utilized in research to explore the biological effects mediated by glucocorticoid receptor activation, including anti-inflammatory responses and cell signaling pathways. Its potency makes GSK866 a valuable tool in studies aimed at understanding the therapeutic potential of glucocorticoids in various diseases. -
Glucocorticoid Receptor Agonist
BAY 1003803 is a selective glucocorticoid receptor agonist that acts by modulating the inflammatory response associated with skin conditions. This compound is primarily utilized in the investigation of psoriasis and severe atopic dermatitis, making it a valuable tool for studying therapeutic approaches in dermatological research. -
GSK866 Enantiomer
(R)-GSK866 is the (R)-enantiomer of GSK866, a selective agonist for the glucocorticoid receptor with an IC50 of 4.6 nM. This compound is valuable for research applications related to inflammation, immune response modulation, and various glucocorticoid receptor signaling pathways. Its specificity and potency make it an important tool for studying the therapeutic potential of glucocorticoid receptor modulation in diverse biological contexts. -
Glucocorticoid Receptor Antagonist
PT150 is a competitive glucocorticoid receptor antagonist with oral bioavailability. It exhibits neuroprotective effects, making it a valuable tool in the study of Parkinson’s disease and related neurodegenerative disorders. Its unique pharmacological profile allows for insights into glucocorticoid signaling pathways in various biological contexts. -
Intermediate For Steroids
21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione serves as a key intermediate in the synthesis of delta 9,11 steroids, such as Vamorolone. These modified glucocorticoids exhibit significant anti-inflammatory properties and contribute to cellular protection against lipid peroxidation. This compound is valuable for research applications focused on the development of therapeutics targeting inflammation and neovascularization. -
Glucocorticoid
Hydrocortisone aceponate is a potent topical glucocorticoid that targets the glucocorticoid receptor. It exhibits anti-inflammatory and immunosuppressive activities, making it effective in the treatment of a variety of dermatoses. This compound is widely utilized in research to investigate the mechanisms of skin inflammation and the therapeutic potential of corticosteroids in dermatological conditions. -
Dexamethasone Derivative
Pyridyl disulfide-Dexamethasone is a modified derivative of Dexamethasone featuring a pyridyl disulfide moiety. This compound serves as a versatile reagent for the synthesis of targeted peptide-steroid conjugates, facilitating studies in steroid biology and drug delivery systems. Its unique structure allows for the exploration of novel therapeutic strategies in hormone signaling and the development of targeted therapies. -
Dexamethasone Prodrug
Dexamethasone phosphate is a prodrug of Dexamethasone that targets inflammatory pathways by undergoing dephosphorylation through erythrocyte enzymes, resulting in the release of the active metabolite into circulation. This compound exhibits potent anti-inflammatory activity, making it suitable for research applications related to steroid-dependent ulcerative colitis. By facilitating targeted delivery, Dexamethasone phosphate enhances therapeutic efficacy in conditions involving inflammation and immune response modulation. -
Corticosteroid Ester
Hydrocortisone 17-valerate is a corticosteroid ester that exhibits significant anti-inflammatory properties. This derivative of hydrocortisone is utilized in various research applications aimed at understanding corticosteroid mechanisms and their effects on inflammation. It serves as a valuable tool in studying inflammation-related pathways and therapeutic interventions in related conditions. -
Steroid Compound
Diflorasone diacetate is a synthetic corticosteroid that exerts anti-inflammatory effects by modulating the immune response and inhibiting pro-inflammatory cytokines. This compound is primarily utilized in dermatological applications to manage corticosteroid-responsive skin disorders, providing relief from conditions such as dermatitis and eczema. Its potent anti-inflammatory activity makes it useful in both research and clinical settings for studying skin inflammation and therapeutic interventions. -
Metabolite of Deflazacort
21-Desacetyldeflazacort is the active metabolite of the immunosuppressant and anti-inflammatory pro-drug Deflazacort. Following oral administration, Deflazacort is converted by esterases into 21-Desacetyldeflazacort, which exerts its pharmacological effects. This compound is primarily used in research applications focused on inflammation and immune response modulation. -
Glucocorticoid Receptor Modulator
C108297 is a selective glucocorticoid receptor (GR) modulator, exhibiting a binding affinity (Ki) of 0.7 nM for GR and a functional Ki of 0.6 nM in reporter gene assays. It has demonstrated the ability to mitigate obesity by decreasing caloric intake while promoting lipolysis and fat oxidation, as well as reducing inflammation. This compound serves as a valuable tool for studying metabolic disorders and the inflammatory response in various biological contexts. -
Glucocorticoid Receptor Agonist
Dagrocorat hydrochloride is a selective partial agonist of the glucocorticoid receptor, exhibiting high affinity and oral bioavailability. This compound functions as a time-dependent reversible inhibitor of CYP3A and CYP2D6, demonstrating inhibitory activity with IC50 values of 1.3 μM and Ki of 0.57 μM, respectively, in human liver microsomes. Dagrocorat hydrochloride is primarily utilized in research related to rheumatoid arthritis, facilitating studies on glucocorticoid signaling pathways and related therapeutic applications. -
Glucocorticoid Receptor Agonist
5α-Tetrahydrocorticosterone is a potent glucocorticoid receptor agonist and a metabolite of corticosterone. It exhibits significant anti-inflammatory activity when applied topically, making it valuable for studying inflammatory skin conditions. In rat hepatocyte studies, it effectively reduces metabolites that bind to the glucocorticoid receptor, demonstrating a dissociation constant (Kd) of 268 nM. This compound is suitable for research focused on the mechanisms of glucocorticoid action and its therapeutic potential in skin inflammation. -
Glucocorticoid Receptor Antagonist
IONIS-GCCRRx is a glucocorticoid receptor antagonist designed as a 2'-O-methoxyethyl (2'-MOE) antisense oligonucleotide (ASO). This compound selectively inhibits glucocorticoid receptor activity, making it valuable in research on inflammatory diseases and metabolic disorders. Its unique mechanism allows for specific modulation of gene expression, facilitating studies on the pathophysiology of glucocorticoid-related conditions. -
Lucocorticoid Receptor Modulator
HP210 is a selective glucocorticoid receptor modulator (SGRM) that primarily targets the glucocorticoid receptor. It effectively inhibits the mRNA expression of pro-inflammatory cytokines IL-1β and IL-6. HP210 is a valuable tool for investigating inflammation-related diseases and exploring therapeutic strategies for conditions driven by glucocorticoid signaling. -
Glucocorticoid
Loteprednol is a synthetic corticosteroid targeting glucocorticoid receptors. It exhibits significant anti-inflammatory, antiallergic, and immunosuppressive activities. This compound is primarily utilized in research related to ocular inflammation, providing insights into therapeutic strategies for various eye disorders. -
Glucocorticoid Receptor Modulator
Prednisolone Tebutate functions as a glucocorticoid receptor modulator, exhibiting significant anti-inflammatory and immunosuppressive properties. It is utilized in research applications focused on inflammation and immune response regulation, making it valuable for studies exploring glucocorticoid signaling pathways and therapeutic interventions in various inflammatory diseases. -
Glucocorticoid
Paramethasone Acetate is a potent glucocorticoid that modulates hormonal pathways by directly inhibiting testicular aromatase, leading to reduced estradiol synthesis. It effectively suppresses luteinizing hormone surges in females and lowers circulating levels of dihydrotestosterone and estradiol in males. Additionally, Paramethasone Acetate demonstrates protective effects against cartilage degeneration and joint damage in osteoarthritis models. This compound is valuable for investigations in osteoarthritis and endocrinology research. -
Glucocorticoid Receptor Modulator
Amebucort is a synthetic glucocorticoid receptor modulator that exhibits potent anti-inflammatory activity. By binding to the glucocorticoid receptor, it regulates gene expression associated with inflammatory response, making it a valuable tool for studying inflammatory disorders. This compound is of particular interest in research focused on autoimmune diseases, chronic inflammation, and related therapeutic applications. -
Budesonide Metabolite
16α-Hydroxy-11-keto prednisolone is a metabolite of Budesonide, targeting the glucocorticoid receptor. This compound exhibits anti-inflammatory properties and is primarily utilized in research related to asthma, rhinitis, and inflammatory bowel disease. Its role in elucidating the effects of glucocorticoids makes it a valuable reagent for studies focusing on respiratory and gastrointestinal inflammation. -
Dexamethasone Metabolite
6β-Hydroxy dexamethasone is an active metabolite of the synthetic glucocorticoid dexamethasone, primarily involved in modulating glucocorticoid receptor activity. This compound exhibits anti-inflammatory and immunosuppressive properties, making it significant for research in chronic inflammatory disorders and autoimmune diseases. Its role as a glucocorticoid metabolite provides insights into drug metabolism and pharmacokinetics, supporting studies related to steroid efficacy and safety. -
Glucocorticoid Receptor Modulator
Zavacorilant is a selective glucocorticoid receptor modulator that alters GR activity, providing potential therapeutic benefits in various conditions. It exhibits distinct biological activity by promoting the anti-inflammatory effects while minimizing unwanted side effects associated with glucocorticoid therapy. This compound is particularly relevant in research focused on inflammation, autoimmune disorders, and metabolic diseases. -
Glucocorticoid
Loteprednol Etabonate-d5 is a deuterium-labeled derivative of Loteprednol etabonate, a novel glucocorticoid with an orally active profile. This compound demonstrates significant anti-inflammatory properties, making it valuable in the fields of optometry and ophthalmology. It is primarily utilized in research related to steroid-mediated anti-inflammatory mechanisms and the development of therapeutic applications targeting ocular conditions. -
Glucocorticoid Receptor Agonist
GR 250495X is a glucocorticoid receptor agonist designed for localized action in the lungs. As an antedrug, it undergoes rapid metabolism and inactivation in the bloodstream, reducing systemic side effects. This reagent is particularly valuable in asthma research, providing insights into therapeutic mechanisms and efficacy in pulmonary conditions. -
corticosteroid
Dexamethasone beloxil is a novel corticosteroid that functions primarily through its anti-inflammatory properties and ability to modulate ocular pressure. It exhibits significant activity in reducing inflammation and is utilized in research settings to investigate therapeutic strategies for ocular diseases and inflammatory conditions. This compound offers valuable insights for the development of treatments in related areas of study. -
Glucocorticoids Receptor Agonist
Glucocorticoids Receptor Agonist 3 is a potent activator of the glucocorticoid receptor, functioning by modulating inflammation and metabolic processes through receptor activation. This compound is primarily utilized in research focused on obesity, diabetes, and inflammatory diseases, providing insights into the underlying mechanisms and potential therapeutic strategies for these conditions. -
Glucocorticoid Derivative
Triamcinolone diacetate is a synthetic glucocorticoid derivative that exhibits significant anti-inflammatory properties. This compound is commonly utilized in research related to conditions such as dermatomyositis, Bell's palsy, and rheumatoid arthritis. Its ability to modulate immune responses makes it a valuable tool in elucidating mechanisms of inflammatory disorders. -
Glucocorticoid Receptor Modulator
Glucocorticoid receptor-IN-1 is a selective modulator of the glucocorticoid receptor (GR) known for its potent anti-inflammatory properties. It demonstrates significant transcriptional repressive activity with an IC50 of 2.11 nM against human matrix metalloproteinase 1 (hMMP1) and exhibits transcriptional activation with an EC50 of 5.59 nM against mouse mammary tumor virus (MMTV). This compound is suitable for research applications focused on inflammation and GR signaling pathways. -
PR Antagonist
JNJ-1250132 is a potent oral steroidal antagonist of the progesterone receptor (PR), exhibiting an IC50 of 1.3 nM. Its primary mechanism involves inhibiting the receptor's binding to DNA, making it valuable for studying PR-mediated processes. Additionally, JNJ-1250132 acts as a competitive inhibitor for both the human glucocorticoid receptor (GR) with an IC50 of 0.50 nM and the rat androgen receptor (AR) with an IC50 of 5.6 nM. This compound's selective profile also shows weak inhibition of the human estrogen receptor (ER), providing insights for research on hormone receptor pathways. -
Glucocorticoid Receptor Modulator
Glucocorticoid Receptor Modulator 2 is a selective modulator of the glucocorticoid receptor, exhibiting an IC50 value of less than 100 nM. This compound is relevant for investigations into inflammatory and immune disorders, as it influences the glucocorticoid signaling pathway. Its pharmacological profile makes it a valuable tool for understanding the mechanisms of action underlying various disease states. -
Glucocorticoid
Cloprednol is a synthetic glucocorticoid that acts primarily through the modulation of glucocorticoid receptors. It exhibits significant anti-inflammatory activity, making it a valuable tool for studying inflammatory conditions such as asthma. Additionally, Cloprednol may be applied in research involving immune response regulation and the investigation of corticosteroid-related mechanisms. -
Edema Formation Inhibitor
SQ 26490 is an active corticoid that functions as a moderate-potency inhibitor of edema formation. It demonstrates efficacy in reducing edema in rat models, making it valuable for studying the underlying mechanisms of edema and its potential treatment strategies in various pathological conditions. Researchers can utilize SQ 26490 to explore its effects on fluid retention and inflammation in animal studies. -
Glucocorticoid Receptor Agonist
LEO 134310 is a selective, non-steroidal agonist of the glucocorticoid receptor (GR). With an EC50 of 14 nM, it exhibits high affinity in GR binding assays. This compound is designed for topical research and has potential applications in studying skin diseases. -
GR Modulator/MR Antagonist
Miricorilant (CORT 118335) functions as a dual selective glucocorticoid receptor (GR) modulator and mineralocorticoid receptor (MR) antagonist. It exhibits significant potential in modulating the effects of glucocorticoids and antagonizing mineralocorticoid activity. This compound is primarily utilized in research focusing on hypothalamic-pituitary-adrenal (HPA) axis disorders, contributing to studies aimed at understanding stress responses and related pathophysiologies. -
Stable Isotope
Beclomethasone-d5 is a deuterium-labeled analogue of Beclometasone, a potent glucocorticoid receptor agonist. This stable isotope is utilized in quantitative analysis of glucocorticoid metabolism and pharmacokinetics. Beclomethasone-d5 serves as an effective tool in research applications focused on inflammatory responses and hormonal regulation. -
Dexamethasone Resistance Reverser
J9 is a small molecule that acts as a Dexamethasone resistance reverser in T-cell acute lymphoblastic leukemia. This compound selectively induces cell lethality in CUTLL1 cells when administered alongside Dexamethasone, demonstrating an effective inhibition of cell growth with an EC50 value of 28 μM. J9 is a valuable tool for exploring mechanisms underlying glucocorticoid resistance and enhancing therapeutic strategies in hematological malignancies.
