BI 653048 is a selective, orally active nonsteroidal glucocorticoid agonist, targeting the glucocorticoid receptor with an IC50 of 55 nM. It inhibits CYP enzyme isoforms including CYP1A2, CYP2D6, CYP2C9, CYP2C19, and CYP3A4, while exhibiting a reduced affinity for the hERG ion channel (IC50 > 30 μM). Additionally, BI 653048 serves as an HCV NS3 protease inhibitor, demonstrating potential for reducing viral loads in hepatitis C virus infections. This compound is valuable in studies related to glucocorticoid signaling and antiviral research.
BI 653048 is a selective, orally active nonsteroidal glucocorticoid agonist, targeting the glucocorticoid receptor with an IC50 of 55 nM. It inhibits CYP enzyme isoforms including CYP1A2, CYP2D6, CYP2C9, CYP2C19, and CYP3A4, while exhibiting a reduced affinity for the hERG ion channel (IC50 > 30 μM). Additionally, BI 653048 serves as an HCV NS3 protease inhibitor, demonstrating potential for reducing viral loads in hepatitis C virus infections. This compound is valuable in studies related to glucocorticoid signaling and antiviral research.
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