Catalog No.
Product Name
Application
Product Information
Citations
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Glucocorticoid Receptor Agonist
Benzodrocortisone is a glucocorticoid receptor agonist that demonstrates anti-inflammatory properties. It is primarily utilized in research investigating eye diseases, where it may help elucidate the role of glucocorticoids in ocular inflammation and related pathologies. Its action on the glucocorticoid receptor can provide insights into therapeutic approaches for various ocular conditions. -
Glucocorticoid Receptor Antagonist
LY2623091 is a potent glucocorticoid receptor antagonist known for its role in modulating mineralocorticoid signaling. This compound demonstrates significant potential in the treatment of refractory hypertension by inhibiting the action of glucocorticoids, thereby addressing hypertension mechanisms. Additionally, LY2623091 exhibits CYP3A4-dependent clearance, presenting possibilities for synergistic therapeutic strategies when used in conjunction with CYP3A4 inhibitors in research applications. -
Budesonide Impurity
Budesonide impurity C is a known impurity associated with Budesonide, a potent inhaled corticosteroid that acts as an agonist of the glucocorticoid receptor. This impurity may play a role in studying the pharmacological profiles and quality control of Budesonide formulations. It is relevant for research applications involving drug stability, metabolism, and the assessment of therapeutic efficacy in inflammatory conditions. -
GR Ligand
(Rac)-GSK866 is a non-steroidal ligand that targets the glucocorticoid receptor (GR). This compound serves as an important tool for investigating GR functionality by providing insights into ligand binding mechanisms. The crystal structure of (Rac)-GSK866 in complex with the GR ligand-binding domain (PDB: 3E7C) can facilitate the exploration of GR-targeted therapeutic strategies and the development of novel GR modulators. -
Glucocorticoid Receptor Activator
Clobetasone 17-Propionate is a potent glucocorticoid receptor activator. It exhibits anti-inflammatory and immunosuppressive properties, making it valuable in the treatment of various dermatological conditions such as eczema and psoriasis. This compound is widely utilized in research applications focused on studying corticosteroid signaling pathways and their effects on immune responses and skin disorders. -
Glucocorticoid Receptor Control
6b-Hydroxy triamcinolone acetonide is a metabolite of the synthetic corticosteroid triamcinolone acetonide, produced through the action of cytochrome P450 isoforms CYP3A4, CYP3A5, and CYP3A7. This compound primarily targets glucocorticoid receptors, exerting anti-inflammatory and immunosuppressive effects. It serves as a valuable reagent in studies investigating glucocorticoid signaling pathways and corticosteroid metabolism. -
Glucocorticoid Receptor Control
Cortolone, also known as α-Cortolone, functions as a selective modulator of the glucocorticoid receptor. As a metabolite of the steroid hormone cortisol, it exhibits significant biological activity by influencing gene expression and immune response regulation. Cortolone is primarily utilized in research applications focused on studying the mechanisms of glucocorticoid action and its therapeutic implications in inflammatory and autoimmune disorders. -
Anti-glucocorticoid Agent
Roxibolone is an anti-glucocorticoid agent that acts as a potent antagonist of glucocorticoid receptors. This compound is effective in mitigating glucocorticoid-induced catabolism without exhibiting androgenic activity. Roxibolone is utilized in research studies focused on glucocorticoid-related metabolic disorders, providing insight into potential therapeutic approaches in this field. -
Glucocorticoid Receptor Modulator
Triamcinolone Benetonide is a synthetic glucocorticoid receptor modulator that exhibits significant anti-inflammatory properties. This compound is utilized primarily in research related to inflammatory processes and immune response regulation. Its ability to modulate glucocorticoid receptor activity makes it a valuable tool for studying corticosteroid mechanisms and investigating potential therapeutic applications in various inflammatory disorders. -
Glucocorticoid Receptor Control
11β-Hydroxyetiocholanolone is a potent modulator of the glucocorticoid receptor, acting as a metabolite of hydrocortisone. This compound is integral to studying glucocorticoid signaling pathways and their physiological impacts. Its biological activities make it valuable for research applications in endocrinology, stress response mechanisms, and the exploration of glucocorticoid receptor-related disorders. -
Glucocorticoid Receptor Ligand
Win 45164 is an orally active ligand of the glucocorticoid receptor, primarily known for its inhibitory effects on the pituitary-adrenal axis. It promotes liver glycogen deposition and thymus involution in adrenalectomized male rats, highlighting its physiological relevance. Additionally, Win 45164 exhibits significant anti-inflammatory properties, making it a valuable tool for research in inflammatory and neurological diseases. -
Prednisolone Metabolite
20α-Dihydro prednisolone is a metabolite of the corticosteroid prednisolone, primarily targeting glucocorticoid receptors. This compound exhibits anti-inflammatory and immunosuppressive properties, making it valuable for investigating the metabolic pathways of corticosteroids and their effects on inflammation and immune responses. It is useful in research applications related to endocrine disorders and pharmacokinetics of steroid medications. -
Glucocorticoid Receptor Antagonist
N-Demethyl Mifepristone serves as a glucocorticoid receptor antagonist, showing 61% affinity relative to its parent compound Mifepristone. This active metabolite is valuable in research investigating glucocorticoid signaling pathways and their implications in various biological processes. Its capacity to modulate receptor activity makes it a useful tool for studying hormonal regulation and potential therapeutic applications in endocrine disorders. -
Alcoholic Metabolite
22-Hydroxy Mifepristone is a hydroxylated alcoholic metabolite that exhibits both antiprogestational and antiglucocorticoidal activities. This compound contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with azide-containing molecules. With a relative binding affinity of 48% to the human glucocorticoid receptor, 22-Hydroxy Mifepristone serves as a valuable tool for research applications focusing on glucocorticoid signaling and receptor interactions. -
Glucocorticoid Receptor
Prednisolone farnesylate is a transdermal corticosteroid that primarily targets the glucocorticoid receptor. This compound exhibits potent anti-inflammatory activity, making it a valuable tool for research in inflammation and autoimmune responses. Its application includes investigation of glucocorticoid signaling pathways and potential therapeutic effects in inflammatory disorders. -
Glucocorticoid Receptor
Betamethasone 17-benzoate is a potent glucocorticoid receptor agonist. It exhibits anti-inflammatory and immunosuppressive properties, making it effective in the treatment of conditions such as recurrent aphthous ulcers. This compound is valuable for research applications related to corticosteroid mechanisms and therapeutic interventions in inflammatory diseases. -
Glucocorticoid Receptor
Timobesone is a synthetic corticosteroid that primarily targets the glucocorticoid receptor, exhibiting anti-inflammatory and immunosuppressive properties. Although not commercially marketed, it has potential applications in research related to inflammatory skin conditions and immune response modulation. Timobesone's ability to activate glucocorticoid signaling pathways makes it a valuable reagent for investigating corticosteroid effects in biological systems. -
NF-κB/AP-1 Inhibitor
Glucocorticoid receptor modulator 1 is a selective non-steroidal modulator that targets the glucocorticoid receptor, exhibiting potent inhibition of NF-κB and AP-1 with IC50 values of 9 nM and 130 nM, respectively. This compound effectively reduces the expression of key inflammatory cytokines, including IL-6, IL-1β, and TNF-α. Additionally, it demonstrates potential in alleviating dermatitis in preclinical models, making it a valuable tool for research in inflammation and immune response. -
Glucocorticoid Receptor Modulator
BMS-791826 is a selective glucocorticoid receptor modulator that targets glucocorticoid receptors to exert its biological effects. This compound effectively inhibits AP-1 and NF-κB-dependent signaling pathways, making it a valuable tool for studying the mechanisms underlying inflammatory diseases. Research applications include the exploration of potential therapeutic strategies for conditions associated with dysregulated glucocorticoid receptor activity. -
Fluticasone Dimer Impurity
Fluticasone dimer impurity is a dimeric form of Fluticasone Propionate, a potent corticosteroid known for its high affinity for glucocorticoid receptors. This impurity may be of interest in investigations related to the stability, purity, and efficacy of Fluticasone formulations. Its assessment can be essential for ensuring quality control in pharmaceutical development and research on corticosteroid activity. -
Corticosteroid Receptor Antagonist
Ocedurenone is a corticosteroid receptor antagonist, primarily targeting the glucocorticoid receptor. This compound exhibits significant biological activity by inhibiting corticosteroid signaling pathways, making it a valuable tool for research applications related to kidney disease and other corticosteroid-mediated disorders. Its utility in investigating the role of corticosteroids in various pathophysiological conditions renders Ocedurenone a critical reagent for scientific studies. -
Finerenone Racemate
(Rac)-Finerenone is a racemate of the selective, orally bioavailable nonsteroidal mineralocorticoid receptor (MR) antagonist, exhibiting an IC50 value of 18 nM. This compound demonstrates significant selectivity over glucocorticoid receptors (GR), androgen receptors (AR), and progesterone receptors, with a selective ratio exceeding 500-fold. (Rac)-Finerenone is utilized in research applications focused on cardiovascular and renal health, and is being investigated for its potential therapeutic benefits in managing disorders related to mineralocorticoid receptor activation. -
Glutathione Depletor
Phorone, a glutathione (GSH) depletor, functions by specifically and reversibly depleting free GSH through enzymatic interaction with glutathione S-transferase (Km = 0.9 mM). This compound has been demonstrated to reversibly affect the binding and nuclear uptake of glucocorticoid receptors in rat liver, correlating with fluctuations in GSH levels. Phorone is valuable for research focused on liver toxicity mechanisms and the role of oxidative stress in cellular dysfunction. -
Endogenous Metabolite
Rofleponide epimer is an endogenous metabolite that targets glucocorticoid receptors, exhibiting significant anti-inflammatory activity. It demonstrates high selectivity for lung tissues and effectively binds to the rat thymic glucocorticoid receptor, reinforcing its pharmacological efficacy. Additionally, Rofleponide epimer has a biotransformation rate that is ten times greater than that of similar compounds, highlighting its potential for therapeutic applications in managing inflammatory diseases affecting mucosal surfaces. -
Steroid
Flumethasone 21-acetate is a synthetic corticosteroid that functions primarily by binding to glucocorticoid receptors, leading to anti-inflammatory and immunosuppressive effects. Its lipophilic properties enhance its ability to penetrate cellular membranes, facilitating therapeutic applications in various inflammatory and autoimmune conditions. This compound is valuable for research focused on corticosteroid mechanisms, inflammatory response modulation, and the development of novel therapeutic strategies. -
Molecular Glue Stabilizer
GR-14-3-3 stabilizer-1 is a molecular glue stabilizer that effectively enhances the stability of glucocorticoid receptors (GR) by preventing their interaction with 14-3-3 proteins. This compound is instrumental in research involving the modulation of GR signaling pathways, providing a valuable tool for studying glucocorticoid-related cellular responses and their implications in various disease states. Its applications extend to the development of novel therapeutic strategies targeting GR dynamics in cellular contexts. -
Target Protein Ligand-Linker Conjugates
Fluocinolone acetonide 3-benzylaniline is a glucocorticoid receptor agonist-linker conjugate that serves as a precursor for the development of antibody-drug conjugates (ADCs) targeting CD40. This compound facilitates the targeted delivery of therapeutics, enhancing efficacy while minimizing off-target effects. Its role in the synthesis of ADCs makes it a valuable tool for research applications in immunology and targeted cancer therapy. -
Stable Isotope
Cyproterone acetate-d3 is a deuterated form of Cyproterone acetate, a synthetic steroid exhibiting anti-androgenic and progestogenic activities. It demonstrates an IC50 of 7.1 nM and binds selectively to progesterone and glucocorticoid receptors. This stable isotope is valuable for research applications involving hormonal regulation, receptor signaling studies, and metabolic pathway investigations involving steroid hormones. -
Estrogen Receptor/ERR
ZK164015 is an estrogen-glucocorticoid receptor chimera that primarily targets the estrogen receptor (ER). This compound serves as a valuable screening tool to assess tissue-selective estrogen activity and has been utilized to investigate ER function in osteoblasts. Studies involving osteoblast-like (ROS and U2OS) and breast cancer (MCF7) cell lines demonstrated that ZK164015 modulates ERE-luciferase reporter activity and influences nuclear mobility, revealing its distinct effects in response to ER agonists. -
Progesterone Receptor Agonist
Dexamethasone oxetanone is an antagonist of glucocorticoid receptors, specifically acting as a potent agonist for progesterone receptor isoforms A and B. This compound exhibits significant antiprogestin activity, making it valuable in studies exploring progesterone signaling pathways. Dexamethasone oxetanone is relevant for research applications in reproductive biology and endocrinology, particularly in understanding the modulation of hormone receptors and their biological effects. -
Progesterone Receptor Inhibitor
CP8754 is a selective antagonist of the human progesterone receptor (hPR), acting primarily by competitively inhibiting the binding of [3H]-progesterone. This compound effectively impedes progesterone-mediated signaling, as evidenced by its ability to inhibit both exogenous luciferase and endogenous alkaline phosphatase expression in vitro, and to suppress rabbit endometrial transformation in vivo. CP8754 exhibits minimal binding affinity for human glucocorticoid receptors, estrogen receptors, and rat androgen receptors, making it a valuable tool for investigating progesterone-related diseases, including breast cancer, endometriosis, uterine fibroids, and hormone-dependent tumors. -
Biochemical Reagent
Triamcinolone acetonide acetate is a synthetic corticosteroid primarily targeting glucocorticoid receptors. It exhibits anti-inflammatory and immunosuppressive properties, making it relevant for research in inflammation, autoimmune diseases, and cancer. This biochemical reagent is also utilized in various assays to study steroid hormone signaling and therapeutic applications. -
Steroid
Alclometasone dipropionate is a topical steroid compound that primarily targets glucocorticoid receptors. It exhibits potent anti-inflammatory and antipruritic activities, making it effective in alleviating symptoms associated with dermatitis and skin itch. This compound is widely utilized in research to investigate its therapeutic potential in dermatological conditions and to better understand the mechanisms underlying skin inflammation. -
Biochemical Assay Reagents
Beclomethasone 21-propionate is a corticosteroid that primarily targets glucocorticoid receptors. It exhibits potent anti-inflammatory properties and is utilized in various biochemical assays related to glycobiology, focusing on the roles of sugars in cellular processes. This compound plays a crucial role in studying carbohydrate chemistry and glycan interactions, contributing to advancements in biomedicine and biotechnology. Its application in research facilitates a deeper understanding of glycan formation, degradation, and recognition mechanisms. -
Corticosteroid Ester
Betamethasone 21-valerate is a corticosteroid ester that exhibits potent anti-inflammatory properties. It acts primarily by binding to glucocorticoid receptors, thereby modulating gene expression and reducing inflammation. This compound is commonly utilized in research applications focused on studying inflammatory processes and evaluating therapeutic interventions in various inflammatory diseases. -
Drug Impurity
Betamethasone dipropionate impurity 2 is a known impurity of the corticosteroid, Betamethasone dipropionate, which serves as a glucocorticoid receptor agonist. This compound may be relevant for research involving the purification and characterization of drug formulations, as well as studies on the stability and efficacy of corticosteroid therapies. Understanding this impurity is essential for ensuring quality control in the production of pharmacologically active compounds. -
Drug Impurity
Fluocinolone impurity 1 is a known impurity of the corticosteroid Fluocinolone, which primarily targets glucocorticoid receptors. This compound serves as a reference standard for quality control in the synthesis and formulation of Fluocinolone, aiding in the assessment of purity and regulatory compliance. Its identification and analysis are crucial for ensuring the integrity of corticosteroid products used in therapeutic applications. -
Drug Intermediate
5-Bromo-1,2-difluoro-3-methoxybenzene serves as a crucial drug intermediate in synthetic chemistry. It functions as a precursor for the development of glucocorticoid receptor (GR) ligands, enabling the exploration of GR-targeted therapies. This compound is applicable in pharmaceutical research for the synthesis of novel therapeutic agents. -
Cloticasone Propionate Intermediate
Cloticasone propionate is an intermediate in the synthesis of Fluticasone propionate, a potent topical anti-inflammatory corticosteroid that selectively targets the glucocorticoid receptor. Its key biological activity includes the inhibition of inflammatory responses, making it valuable in the development of therapeutic agents for various inflammatory conditions. This compound is primarily utilized in research focused on corticosteroid synthesis and the evaluation of inflammation-related pathways. -
Dexamethasone Ester
Dexamethasone dipropionate is an ester derivative of Dexamethasone that primarily acts as a glucocorticoid receptor agonist. It exhibits anti-inflammatory and immunosuppressive properties, making it a valuable tool in the study of various inflammatory conditions, including osteoarthritis. This compound is utilized in research to investigate its effects on joint inflammation and related therapeutic applications. -
Glucocorticoid Steroid
Flurandrenolone Acetate is a synthetic glucocorticoid steroid that functions primarily through the glucocorticoid receptor. It exhibits potent anti-inflammatory and immunosuppressive properties, making it valuable for investigating skin disorders such as eczema and psoriasis. This compound is essential for research focused on therapeutic strategies targeting inflammatory pathways and understanding the mechanisms underlying skin-related conditions. -
Drug Derivative
Flumedroxone acetate is a synthetic glucocorticoid derivative that primarily targets the glucocorticoid receptor. It exhibits anti-inflammatory and immunosuppressive activities, making it useful in research applications related to inflammation, autoimmune diseases, and other disorders governed by the immune system. Its bioactivity enables investigations into the mechanisms of steroid resistance and therapeutic strategies for related pathologies. -
Glucocorticoid Corticosteroid
Halobetasol propionate is a synthetic glucocorticoid corticosteroid that primarily targets the glucocorticoid receptor. This compound demonstrates significant anti-inflammatory, antipruritic, and vasoconstrictive properties, making it an effective agent in the treatment of inflammatory skin conditions. Halobetasol propionate is commonly utilized in research focused on psoriasis and other related dermatological disorders. -
Glucocorticoid Receptor Agonist
Hydrocortisone cypionate is a synthetic glucocorticoid corticosteroid that acts as a potent agonist of the glucocorticoid receptor. This compound exhibits anti-inflammatory and immunosuppressive properties, making it valuable for research applications related to inflammation, immune response modulation, and endocrine regulation. It is commonly utilized in studies investigating the effects of glucocorticoids on various biological processes and disease models. -
Glucocorticoid Agonist
Methylprednisolone succinate sodium is a prodrug of methylprednisolone and acts as a glucocorticoid agonist. It exhibits significant immunosuppressant and anti-inflammatory properties by binding to cytosolic glucocorticoid receptors, which facilitates the modulation of target gene transcription. This compound influences the expression of key proteins such as Bax, Bcl-2, occludin, and ZO-1, while also attenuating TLR4/NF-κB signaling, suppressing proinflammatory cytokine production, and inhibiting immune cell activation. Methylprednisolone succinate sodium is valuable for research related to intracranial hemorrhage, rheumatoid arthritis, multiple sclerosis, and various inflammatory conditions. -
Anti-Inflammatory Corticosteroid
Paramethasone is an anti-inflammatory corticosteroid that targets glucocorticoid receptors. It is known for its ability to reduce inflammation and modulate immune responses, making it valuable in the treatment of various inflammatory and autoimmune conditions. This compound is commonly utilized in research to investigate corticosteroid mechanisms and therapeutic applications in disorders such as asthma, arthritis, and other inflammatory diseases. -
Ginsenoside
Ginsenoside mRb2 is a protopanaxadiol-type ginsenoside that primarily targets the glucocorticoid receptor. It exhibits various biological activities, including anti-inflammatory and antioxidant effects. This compound is frequently utilized in research focused on chronic diseases, neuroprotection, and metabolic disorders, making it a valuable tool for understanding the therapeutic potential of ginsenosides in pharmacological studies.
