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Glucocorticoid receptor agonist-4 Ala-Ala-Mal

Catalog No.: A26057
hTNFa Antibody-GC Conjugate
Glucocorticoid receptor agonist-4 Ala-Ala-Mal is a conjugate of an anti-human TNFα antibody and a glucocorticoid receptor agonist. This compound is designed to selectively target and activate glucocorticoid receptors, demonstrating significant anti-inflammatory properties. It is primarily utilized in research focused on autoimmune and inflammatory diseases, enabling in-depth studies of immune response modulation and therapeutic interventions.
Glucocorticoid receptor agonist-4 Ala-Ala-Mal 3014393-37-1 hTNFa Antibody-GC Conjugate
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGlucocorticoid receptor agonist-4 Ala-Ala-Mal is a conjugate of an anti-human TNFα antibody and a glucocorticoid receptor agonist. This compound is designed to selectively target and activate glucocorticoid receptors, demonstrating significant anti-inflammatory properties. It is primarily utilized in research focused on autoimmune and inflammatory diseases, enabling in-depth studies of immune response modulation and therapeutic interventions.
Product Information
Catalog NumA26057
FormulaC49H55FN4O12
Molecular Weight910.98
CAS Number3014393-37-1
SMILESOCC([C@]12[C@@]3([C@@]([C@@]4([H])[C@]([C@@]5(C(CC4)=CC(C=C5)=O)C)([H])[C@H](C3)O)([H])C[C@@]1([H])O[C@@H](C6=C(C(OCC7=CC(NC([C@H](C)NC([C@H](C)NC(CCN8C(C=CC8=O)=O)=O)=O)=O)=CC=C7)=CC=C6C)F)O2)C)=O
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Endocrinology-Hormones > Glucocorticoid receptors