Glucocorticoid receptor modulator 3 is a potent thioester-containing modulator of the glucocorticoid receptor with an IC50 of 0.6 nM. This compound is designed to facilitate the rapid inactivation of unconjugated payloads via hepatic metabolism, thereby reducing systemic exposure. Its specific activity makes it a valuable tool in the development of antibody-drug conjugates (ADCs) aimed at treating autoimmune diseases.
Glucocorticoid receptor modulator 3 is a potent thioester-containing modulator of the glucocorticoid receptor with an IC50 of 0.6 nM. This compound is designed to facilitate the rapid inactivation of unconjugated payloads via hepatic metabolism, thereby reducing systemic exposure. Its specific activity makes it a valuable tool in the development of antibody-drug conjugates (ADCs) aimed at treating autoimmune diseases.
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