Glucocorticoid receptor-IN-2 is a selective modulator of the glucocorticoid receptor (GR) that exhibits significant anti-inflammatory properties. This compound demonstrates notable transcriptional repressive activity with an IC50 of 0.171 nM against human matrix metalloproteinase 1 (hMMP1), while also showing comparable transcriptional activation activity with an EC50 of 0.94 nM against mouse mammary tumor virus (MMTV). It is a valuable reagent for research into GR-mediated pathways and the development of therapies targeting inflammation.
Glucocorticoid receptor-IN-2 is a selective modulator of the glucocorticoid receptor (GR) that exhibits significant anti-inflammatory properties. This compound demonstrates notable transcriptional repressive activity with an IC50 of 0.171 nM against human matrix metalloproteinase 1 (hMMP1), while also showing comparable transcriptional activation activity with an EC50 of 0.94 nM against mouse mammary tumor virus (MMTV). It is a valuable reagent for research into GR-mediated pathways and the development of therapies targeting inflammation.
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