Catalog No.
Product Name
Application
Product Information
Citations
-
GnRH Antagonist
Abarelix Acetate is a potent gonadotropin-releasing hormone (GnRH) antagonist targeting GnRH receptors. It is primarily utilized in prostate cancer research, where it plays a crucial role in inhibiting the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This compound is instrumental in exploring therapeutic strategies for androgen-dependent tumors through its effects on hormone regulation. -
GnRH Analogue
sGnRH-A is a salmon gonadotropin-releasing hormone (GnRH) analogue that primarily targets the GnRH receptors. This compound effectively stimulates the secretion of growth hormone, making it valuable in studies related to hormonal regulation. Additionally, sGnRH-A serves as an inducer of ovulation and is commonly utilized in artificial insemination protocols for reproductive research and agricultural applications. -
GnRH Receptor Antagonist
AG-045572 is a potent antagonist of the gonadotropin-releasing hormone (GnRH) receptor, exhibiting Ki values of 6.0 nM for the human and 3.8 nM for the rat GnRH receptor. This compound is metabolized by CYP3A and effectively represses testosterone levels, making it valuable for research on reproductive hormone regulation and potential therapeutic applications in hormone-dependent conditions. Its specific activity highlights its relevance in pharmacological studies focusing on reproductive health and endocrine function. -
GnRH-R Antagonist
GnRH-R antagonist 1 is a potent GnRH receptor antagonist that exhibits high binding affinity with an IC50 of 0.57 nM and strong in vitro antagonistic activity at an IC50 of 2.18 nM. This compound is membrane-permeable and orally bioavailable, making it suitable for various research applications. It is particularly valuable in studies focused on advanced prostate cancer and in investigating the prevention of premature luteinizing hormone peaks. -
GnRH Antagonist
Merigolix is a potent gonadotropin-releasing hormone (GnRH) antagonist that effectively inhibits the release of gonadotropins such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This compound is primarily utilized in research related to reproductive biology and endocrinology, facilitating the study of hormonal regulation and the modulation of reproductive functions. Its application in animal models can aid in the exploration of fertility treatments and hormonal therapies. -
GnRH Antagonist
Linzagolix choline is a non-peptide gonadotropin-releasing hormone (GnRH) antagonist that acts by binding to GnRH receptors in the pituitary gland, thereby inhibiting the secretion of endogenous gonadotropins, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This mechanism leads to decreased levels of sex hormones such as estrogen and progesterone, making it valuable for investigating sex hormone-dependent conditions. Linzagolix choline is particularly relevant in the research of disorders such as endometriosis and uterine fibroids. -
LHRH Analogue
(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH) that primarily targets the LHRH receptor. This compound is designed to modulate reproductive hormone release by stimulating the secretion of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It serves as a valuable tool in reproductive biology and endocrinology research, particularly in studies related to fertility and hormonal regulation. -
GnRH Agonist
Avorelin is a gonadotropin-releasing hormone (GnRH) agonist that stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This compound is primarily utilized in research related to hormone regulation and reproductive biology. Avorelin is particularly relevant for studies investigating prostate cancer, as it can influence hormone-dependent tumor growth and serve as a potential therapeutic agent. -
LHRH Antagonist
Argtide is a luteinizing hormone-releasing hormone (LHRH) antagonist that effectively inhibits the release of gonadotropins. This compound is utilized in research related to endometriosis and hormone-sensitive cancers, providing valuable insights into therapeutic strategies and mechanisms of action. Its role in modulating LHRH signaling pathways makes it an important tool for studying reproductive and oncological health. -
GnRH analogue
Federelin is a gonadotropin-releasing hormone (GnRH) analog that acts by binding to GnRH receptors to stimulate the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This compound plays a significant role in reproductive biology and is used in research applications involving hormonal regulation, fertility studies, and endocrine system investigations. Its ability to modulate hormone levels makes it a valuable tool in studying reproductive health and related disorders. -
Gonadotropic Function Blocker
Metallibure is a dithiocarbamoylhydrazine derivative that functions as a gonadotropic function blocker. It effectively inhibits the action of pituitary gonadotropins in teleost fish, subsequently blocking germ cell maturation. Additionally, Metallibure has been shown to reduce the nuclear volume of thyroid epithelial cells without causing significant histological changes to the thyroid gland. This compound is valuable for investigating endocrine disorders and related biological processes. -
GnRH Receptor Antagonist
ORG 30276 is a potent GnRH receptor antagonist that effectively inhibits gonadotropin secretion by reducing serum LH and FSH levels. It decreases the expression of unoccupied pituitary GnRH receptors, resulting in significant downregulation of gonadotropin beta-subunit mRNA in the pituitary gland. The modulatory effects of ORG 30276 on gonadotropin dynamics can be selectively reversed by the administration of specific sex steroids, particularly androgens, which notably influence FSH beta-subunit mRNA levels. This compound is valuable for research in reproductive biology and endocrine regulation. -
GnRH Receptor Agonist
[Ala6]-LHRH is a synthetic analog of luteinizing hormone-releasing hormone (GnRH) that functions as a potent agonist for GnRH receptors. This compound effectively stimulates the secretion of luteinizing hormone from the pituitary gland, thereby enhancing reproductive hormone regulation. [Ala6]-LHRH is instrumental in fertility treatments and plays a significant role in managing conditions associated with hormone imbalances. -
GnRH Receptor Agonist
Histrelin is a GnRH receptor agonist that functions by stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to elevated testosterone levels. This compound serves as a valuable tool in research related to prostate cancer and endometriosis by modulating hormonal pathways. Histrelin's ability to influence reproductive hormone levels makes it instrumental in exploring treatments for hormone-dependent conditions. -
LHRH Analogue
(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH), targeting the LHRH receptor. This compound enhances the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), playing a crucial role in regulating reproductive functions. It is valuable for research applications focused on reproductive biology and hormone signaling pathways. -
GnRH Receptor Antagonist
Elagolix is a selective, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRH receptor) with a dissociation constant (KD) of 54 pM. This compound exhibits potent biological activity in modulating hormonal signaling and is primarily utilized in research focused on endometriosis-related pain mechanisms. Its ability to inhibit NFAT pathways further expands its potential applications in investigating reproductive health and endocrine disorders. -
GnRH
LH-RH (4-10) is a heptapeptide derived from luteinizing hormone-releasing hormone (LHRH) through enzymatic degradation in the pituitary and hypothalamus. This peptide plays a crucial role in the regulation of gonadotropin secretion and is known to influence reproductive functions. LH-RH (4-10) is valuable in research applications including studies on hormonal regulation, reproductive physiology, and neuroendocrine signaling pathways. -
LHRH Analogue
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a potent Luteinizing-hormone-releasing hormone (LHRH) analogue that functions as a GnRH receptor antagonist. This compound demonstrates significant activity in inhibiting luteinizing hormone release, making it valuable for research in reproductive biology and endocrinology. Its application extends to studies investigating hormone regulation and potential therapeutic interventions in hormone-sensitive conditions. -
LHRH Antagonist
[D-Phe2,6, Pro3]-LH-RH is a potent luteinizing hormone-releasing hormone (LHRH) antagonist that effectively inhibits the action of LHRH. This compound plays a critical role in regulating reproductive physiology by blocking the secretion of luteinizing hormone and follicle-stimulating hormone. It is widely used in research applications focused on hormone regulation, reproductive biology, and the study of pituitary function. -
LHRH Analogue
Onvitrelin ucalontide is an analogue of luteinizing hormone-releasing hormone (LHRH) that demonstrates antineoplastic activity. This peptide, with the sequence KFAKFAKKFAKFAKKFAKQHWSYGLRPG, has been shown to effectively inhibit the growth of breast cancer, ovarian cancer, and prostate cancer xenografts in mouse models. Its application in cancer research provides insights into hormonal regulation and therapeutic strategies targeting LHRH pathways. -
GnRH Antagonist
GnRH Antagonist 3 is a potent gonadotropin-releasing hormone (GnRH) antagonist, exhibiting an IC50 value of 7 nM. This compound effectively inhibits GnRH activity, making it a valuable tool for research into hormone-dependent diseases. Its use may extend to studies in reproductive biology and the development of therapeutics targeting GnRH-related conditions. -
GnRH Receptor Agonist
[D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH is a potent gonadotropin-releasing hormone (GnRH) receptor agonist. This compound exhibits dose-dependent inhibition of progesterone secretion from cultured human granulosa cells, making it a valuable tool for studying reproductive hormone regulation. Its applications extend to research in reproductive biology and endocrinology, providing insights into GnRH signaling mechanisms. -
GnRH Receptor Antagonist
Azaline is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist, exhibiting a KD value of 0.48 nM. It effectively induces histamine release, comparable to GnRH, and can completely inhibit ovulation in female rats at doses of 2.0-3.0 μg. Azaline holds potential applications in the investigation of reproductive functions and hormonal regulation. -
Stable Isotope
Elagolix-d9 is a deuterium-labeled version of Elagolix, a selective, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist with a binding affinity (KD) of 54 pM. This stable isotope is valuable for studies related to endometriosis-associated pain, enabling researchers to track metabolic pathways and enhance understanding of GnRH receptor modulation. Elagolix-d9 serves as a useful tool for elucidating the mechanisms of action and therapeutic potential in reproductive health research. -
GnRH
Lamprey LH-RH I is a gonadotropin-releasing hormone (GnRH) that primarily stimulates the release of gonadotropins. It induces an increase in plasma steroid levels and facilitates ovulation in lampreys, demonstrating specific biological activity in this model organism. This compound is useful for studies focused on reproductive physiology and endocrine regulation in aquatic vertebrates. -
GnRH Analog
Fertirelin acetate is a gonadotropin-releasing hormone (GnRH) analog that primarily targets the GnRH receptor. It is involved in regulating reproductive hormone secretion and is used in research to study the reversal of follicular cysts in cows. This compound serves as an important tool for investigating reproductive health and management in veterinary science. -
LHRH Antagonist
A-75998 is a luteinizing hormone-releasing hormone (LHRH) antagonist that inhibits the action of LHRH at its receptor. This compound is primarily utilized in the study of hormone-sensitive cancers and endometriosis, where modulation of LHRH signaling may provide therapeutic benefits. Its ability to disrupt hormone signaling pathways makes it a valuable reagent for research into treatments targeting these conditions. -
GnRH-R Antagonist
WAY-207024 is an orally active antagonist of the gonadotropin-releasing hormone receptor (GnRH-R), exhibiting an IC50 of 12 nM for human GnRH and 71 nM for rat GnRH. This compound effectively inhibits luteinizing hormone (LH) release in rats, with an IC50 of 350 nM, and significantly reduces plasma LH levels following oral administration. WAY-207024 is a valuable tool for research into reproductive biology and potential therapeutic interventions targeting hormonal regulation. -
GnRH Antagonist
Acyline is a GnRH antagonist that effectively inhibits gonadotropin release, leading to decreased testosterone levels. Its primary mechanism involves blocking the GnRH receptor, making it valuable in studies of hormonal regulation and reproductive biology. Acyline is widely used in research applications focused on fertility control, hormone-dependent diseases, and endocrine disruption. -
GnRH-R Antagonist
WAY-207024 dihydrochloride is a potent antagonist of the gonadotropin-releasing hormone receptor (GnRH-R), exhibiting an IC50 of 12 nM for human GnRH and 71 nM for rat GnRH. This compound effectively inhibits the release of luteinizing hormone (LH) in rats, with an IC50 of 350 nM. WAY-207024 dihydrochloride is useful for studying the regulation of reproductive hormones and exploring therapeutic strategies for disorders related to GnRH signaling. -
Peptide
(D-His2)-Goserelin is a peptide analog derived from Goserelin, which mimics the structure of gonadotropin-releasing hormone (GnRH/LHRH). This compound serves primarily as an agonist of GnRH receptors, influencing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Its biological activity makes it valuable in research focused on reproductive biology, endocrinology, and fertility treatments. -
Progesterone
Fluorogestone acetate is a synthetic progesterone analog that primarily targets the progesterone receptor. It effectively inhibits ovulation and regulates the estrous cycle in cattle by suppressing luteinizing hormone (LH) release from the pituitary gland. This compound is widely used in veterinary medicine for reproductive management and synchronization protocols. -
GnRH
LH-RH (7-10) targets the gonadotropin-releasing hormone (GnRH) pathway and serves as a significant degradation product of luteinizing hormone-releasing hormone. This tetrapeptide is produced by macrophages and type I and type II pneumocytes, playing a role in various physiological processes. Its applications in research include studies on reproductive health and endocrine regulation. -
LH/FSH Release Agonist
[Lys8] LH-RH is an agonist of luteinizing hormone-releasing hormone (LH-RH) that effectively stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This compound is valuable for research applications investigating reproductive endocrinology and hormonal regulation. Its ability to modulate LH and FSH levels makes it a useful tool for studies on fertility, reproductive health, and related therapeutic interventions. -
GnRH Antagonist
Azaline B is a potent antagonist of gonadotropin-releasing hormone (GnRH) with an IC50 of 1.37 nM. This compound exhibits significant biological activity in modulating reproductive hormone pathways, making it valuable for research into sex hormone-related disorders, ovulation induction, and male contraception. Its specificity and potency position Azaline B as a crucial tool for advancing the understanding of reproductive biology and therapeutic interventions in related pathological states. -
Recombinant Human Luteinizing Hormone
Lutropin alfa is a recombinant human luteinizing hormone (LH) that acts through the activation of LH receptors. Its biological activity closely resembles that of natural luteinizing hormone, promoting follicular development and ovulation. This reagent is primarily used in infertility treatments to support reproductive health and facilitate assisted reproductive technologies. -
LHRH Analogue
(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH is a luteinizing hormone-releasing hormone (LHRH) analogue that functions by mimicking the natural hormone to regulate reproduction. It stimulates the secretion of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH), making it significant for research on reproductive endocrinology. This compound can be utilized in studies investigating various aspects of reproductive health and hormonal regulation. -
LHRH Derivatives
(D-His(Bzl)6)-LHRH (1-7) free acid is a synthetic derivative of luteinizing hormone-releasing hormone (LHRH) that features modifications to enhance stability and biological activity. By incorporating unnatural amino acids, this peptide exhibits improved half-life and reduced metabolism, facilitating increased efficacy in inhibiting cell proliferation. It is suitable for applications in cancer research and studies related to hormone regulation. -
GnRH Receptor Antagonist
Org-30850 is a potent GnRH receptor antagonist that effectively targets hormone-dependent disorders. Preclinical studies demonstrate its capability to inhibit ovulation in female rats and significantly lower testosterone levels in males for up to 48 hours following a single subcutaneous administration. Administration of daily doses in female rats resulted in suppression of estrous cycles and reduction of uterine and ovarian weights, accompanied by decreased estradiol and FSH serum levels. In male rats, prolonged treatment led to reversible declines in gonadal function and testosterone levels, with nearly complete recovery after treatment cessation. Org-30850 is characterized by minimal injection site irritation, indicating a potentially more favorable therapeutic profile. -
LHRH Antagonist
[D-Phe2,D-Ala6]-LH-RH is a potent antagonist of luteinizing hormone-releasing hormone (LH-RH). This compound effectively inhibits the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), demonstrating significant antiovulatory activity. It is primarily utilized in reproductive biology research to explore mechanisms of hormone regulation and fertility control. -
GPR54/GnRH Receptor Activator
Kisspeptin 13 functions as an activator of the G protein-coupled receptor GPR54 and the gonadotropin-releasing hormone (GnRH) receptor. This peptide is known to inhibit glucose-induced insulin secretion with an IC50 of 1.2 nM and plays a role in activating the hypothalamic-pituitary-adrenal (HPA) axis, which can induce hyperthermia and influence motor behavior and anxiety in animal models. Additionally, Kisspeptin 13 has been implicated in enhancing memory, suggesting potential applications in Alzheimer's disease research. Its interactions with α2-adrenergic and 5-HT2 serotonin receptors further indicate its antidepressant-like properties. -
GnRH Analogs
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon) is a GnRH analog that primarily targets gonadotropin-releasing hormone receptors. It is known to effectively induce ovulation and spawning in farmed fish, making it a valuable tool in aquaculture research. This compound aids in the study of reproductive processes and hormone regulation in aquatic species. -
LHRH Analogue
[D-Ala6]-LH-RH is a synthetic analogue of Luteinizing Hormone-Releasing Hormone (LHRH) that functions as a gonadotropin-releasing hormone (GnRH) receptor agonist. This compound is utilized in research to study the regulation of reproductive hormones and to investigate its potential roles in reproductive health and disorders. Its applications include the exploration of mechanisms underlying hormone signaling and the development of therapeutic strategies for conditions such as hormone-dependent cancers. -
GnRH-R Antagonist
GnRH-R Antagonist-2 is a selective antagonist of the Gonadotropin-Releasing Hormone Receptor (GnRH-R), exhibiting IC50 values of 43 nM for rat and 88 nM for human receptors. This compound is pivotal in studying hormone-dependent conditions, such as endometriosis and breast and prostate cancers. Its specificity makes it a valuable tool for elucidating the roles of GnRH signaling in various biological contexts and developing targeted therapies. -
Progesterone Derivatives
5α-Pregnane-3α,20α-diol is a progesterone derivative known as Allopregnanediol. It demonstrates significant biological activity by stimulating the release of luteinizing hormone (LH) in estrogen-pretreated castrated rats, while concurrently inhibiting follicle-stimulating hormone (FSH) secretion. This compound is valuable in research related to reproductive biology and hormonal regulation, providing insights into steroid hormone functions and their physiological effects. -
LHRH Antagonist
RS-18286 is a potent luteinizing hormone-releasing hormone (LHRH) antagonist that effectively blocks the pituitary LHRH receptor. By inhibiting this receptor, RS-18286 suppresses the secretion of luteinizing hormone (LH) from the pituitary gland, leading to decreased serum levels of gonadal steroids. This compound can be utilized in research applications related to reproductive biology and endocrinology. -
LHRH Agonist
Lutrelin is a luteinizing hormone-releasing hormone (LHRH) agonist that plays a critical role in regulating reproductive hormone levels. This compound has been shown to inhibit the growth of endometrial explants in rat models, making it valuable for research in reproductive biology and the study of endometrial disorders. Its applications extend to both basic research and therapeutic investigations related to hormonal regulation. -
Androgen Prodrug
Dimethandrolone undecanoate is an androgen prodrug that exhibits both androgenic and progestogenic activity. By inhibiting the production of gonadotropins, it suppresses testosterone synthesis, resulting in a decrease in sperm production. This compound holds significant promise for the development of male hormonal contraceptives and other applications in hormonal research. -
LHRH Antagonist
A-76154 is a potent LHRH antagonist that functions by inhibiting the action of luteinizing hormone-releasing hormone, thereby regulating gonadotropin secretion. This reduced-size octapeptide is valuable for research applications in reproductive biology and hormone regulation studies. It serves as an important tool for investigating therapeutic interventions in hormone-related disorders and conditions such as hormone-sensitive cancers. -
GnRH Antagonist
MI-1544 is a potent GnRH antagonist that effectively inhibits pituitary LH release and suppresses gonadal function. This compound is valuable for research applications focused on understanding antifertility mechanisms and exploring therapeutic approaches related to reproductive health.
