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D-pGlu1,D-Phe2,D-NaI3,6-Gn-RH

Catalog No.: A60723
GnRH Receptor Agonist
[D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH is a potent gonadotropin-releasing hormone (GnRH) receptor agonist. This compound exhibits dose-dependent inhibition of progesterone secretion from cultured human granulosa cells, making it a valuable tool for studying reproductive hormone regulation. Its applications extend to research in reproductive biology and endocrinology, providing insights into GnRH signaling mechanisms.
[D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH 78255-70-6 GnRH Receptor Agonist
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25mg
$1,275.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description[D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH is a potent gonadotropin-releasing hormone (GnRH) receptor agonist. This compound exhibits dose-dependent inhibition of progesterone secretion from cultured human granulosa cells, making it a valuable tool for studying reproductive hormone regulation. Its applications extend to research in reproductive biology and endocrinology, providing insights into GnRH signaling mechanisms.
Product Information
Catalog NumA60723
FormulaC71H86N14O13
Molecular Weight1343.53
CAS Number78255-70-6
Sequence{d-pGlu}-{d-Phe}-{d-NaI}-Ser-Tyr-{d-NaI}-Leu-Arg-Pro-Gly-NH2 (d-Nal = 3-(1-naphthyl)-D-alanine)
Sequence shortening{d-pGlu}-{d-Phe}-{d-NaI}-SY-{d-NaI}-LRPG-NH2 (d-Nal = 3-(1-naphthyl)-D-alanine)
SMILESCC(C)C[C@H](NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O
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Endocrinology-Hormones > GnRH receptor