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Histrelin (GnRH analogue)

Catalog No.: A60713
GnRH Receptor Agonist
Histrelin is a GnRH receptor agonist that functions by stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to elevated testosterone levels. This compound serves as a valuable tool in research related to prostate cancer and endometriosis by modulating hormonal pathways. Histrelin's ability to influence reproductive hormone levels makes it instrumental in exploring treatments for hormone-dependent conditions.
Histrelin (GnRH analogue) 76712-82-8 GnRH Receptor Agonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionHistrelin is a GnRH receptor agonist that functions by stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to elevated testosterone levels. This compound serves as a valuable tool in research related to prostate cancer and endometriosis by modulating hormonal pathways. Histrelin's ability to influence reproductive hormone levels makes it instrumental in exploring treatments for hormone-dependent conditions.
Product Information
Catalog NumA60713
FormulaC66H86N18O12
Molecular Weight1323.50
CAS Number76712-82-8
Sequence{Pyr}-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt
Sequence shortening{Pyr}-HWSYHLRP-NHEt
SMILESCCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CN(C=N2)CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
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Endocrinology-Hormones > GnRH receptor