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RS-18286

Catalog No.: A60755
LHRH Antagonist
RS-18286 is a potent luteinizing hormone-releasing hormone (LHRH) antagonist that effectively blocks the pituitary LHRH receptor. By inhibiting this receptor, RS-18286 suppresses the secretion of luteinizing hormone (LH) from the pituitary gland, leading to decreased serum levels of gonadal steroids. This compound can be utilized in research applications related to reproductive biology and endocrinology.
RS-18286 109458-76-6 LHRH Antagonist
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Size Price Stock Qty
25mg
$1,275.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRS-18286 is a potent luteinizing hormone-releasing hormone (LHRH) antagonist that effectively blocks the pituitary LHRH receptor. By inhibiting this receptor, RS-18286 suppresses the secretion of luteinizing hormone (LH) from the pituitary gland, leading to decreased serum levels of gonadal steroids. This compound can be utilized in research applications related to reproductive biology and endocrinology.
Product Information
Catalog NumA60755
FormulaC74H101Cl2N17O14
Molecular Weight1523.61
CAS Number109458-76-6
SequenceAc-{d-Phe}-{d-Phe}-{d-Trp}-Ser-Tyr-{d-Har}-Leu-Arg-Pro-{d-Ala}
Sequence shorteningAc-{d-Phe}-{d-Phe}-{d-Trp}-SY-{d-Har}-LRP-{d-Ala}
SMILESC([C@@H](NC([C@@H](CC1=CC=C(Cl)C=C1)NC([C@@H](CC2=CC=C(Cl)C=C2)NC(C)=O)=O)=O)C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(N[C@@H](C(O)=O)C)=O)CCC4)CCCNC(=N)N)=O)CC(C)C)=O)CCCCN=C(NCC)NCC)=O)=O)CO)=O)C=5C=6C(NC5)=CC=CC6
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Endocrinology-Hormones > GnRH receptor