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Azaline B

Catalog No.: A60739
GnRH Antagonist
Azaline B is a potent antagonist of gonadotropin-releasing hormone (GnRH) with an IC50 of 1.37 nM. This compound exhibits significant biological activity in modulating reproductive hormone pathways, making it valuable for research into sex hormone-related disorders, ovulation induction, and male contraception. Its specificity and potency position Azaline B as a crucial tool for advancing the understanding of reproductive biology and therapeutic interventions in related pathological states.
Azaline B 134457-28-6 GnRH Antagonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAzaline B is a potent antagonist of gonadotropin-releasing hormone (GnRH) with an IC50 of 1.37 nM. This compound exhibits significant biological activity in modulating reproductive hormone pathways, making it valuable for research into sex hormone-related disorders, ovulation induction, and male contraception. Its specificity and potency position Azaline B as a crucial tool for advancing the understanding of reproductive biology and therapeutic interventions in related pathological states.
Product Information
Catalog NumA60739
FormulaC80H102ClN23O12
Molecular Weight1613.27
CAS Number134457-28-6
SequenceAc-{d-Ala<2Nal>}-{d-Phe}-{d-Ala}-Ser-{Phe}-{d-Phe}-Leu-{Lys}-Pro-{d-Ala} X=3-amino-1H-1,2,4-triazol-5-yl)amino
Sequence shorteningAc-{d-Ala<2Nal>}-{d-Phe}-{d-Ala}-S-{Phe}-{d-Phe}-L-{Lys}-P-{d-Ala} X=3-amino-1H-1,2,4-triazol-5-yl)amino
SMILESC([C@@H](NC([C@@H](NC([C@@H](CC1=CC=C(NC=2NC(N)=NN2)C=C1)NC([C@H](CC3=CC=C(NC=4NC(N)=NN4)C=C3)NC([C@@H](NC([C@@H](CC=5C=CC=NC5)NC([C@@H](CC6=CC=C(Cl)C=C6)NC([C@@H](CC7=CC8=C(C=C7)C=CC=C8)NC(C)=O)=O)=O)=O)CO)=O)=O)=O)CC(C)C)=O)CCCCNC(C)C)(=O)N9[C@H](C(N[C@@H](C(N)=O)C)=O)CCC9
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Endocrinology-Hormones > GnRH receptor