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D-Phe2,D-Ala6-LH-RH

Catalog No.: A60746
LHRH Antagonist
[D-Phe2,D-Ala6]-LH-RH is a potent antagonist of luteinizing hormone-releasing hormone (LH-RH). This compound effectively inhibits the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), demonstrating significant antiovulatory activity. It is primarily utilized in reproductive biology research to explore mechanisms of hormone regulation and fertility control.
[D-Phe2,D-Ala6]-LH-RH 54784-44-0 LHRH Antagonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description[D-Phe2,D-Ala6]-LH-RH is a potent antagonist of luteinizing hormone-releasing hormone (LH-RH). This compound effectively inhibits the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), demonstrating significant antiovulatory activity. It is primarily utilized in reproductive biology research to explore mechanisms of hormone regulation and fertility control.
Product Information
Catalog NumA60746
FormulaC59H79N15O13
Molecular Weight1206.35
CAS Number54784-44-0
Sequence shortening{Glp}-{d-Phe}-WSY-{d-Ala}-LRPG-NH2
SMILESC([C@H](NC([C@@H](CC1=CC=CC=C1)NC(=O)[C@H]2NC(=O)CC2)=O)C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(NCC(N)=O)=O)CCC4)CCCNC(=N)N)=O)CC(C)C)=O)C)=O)=O)CO)=O)C=5C=6C(NC5)=CC=CC6
SynonymsWy 18185
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Endocrinology-Hormones > GnRH receptor