Metallibure

Catalog No.: A60705
Gonadotropic Function Blocker
Metallibure is a dithiocarbamoylhydrazine derivative that functions as a gonadotropic function blocker. It effectively inhibits the action of pituitary gonadotropins in teleost fish, subsequently blocking germ cell maturation. Additionally, Metallibure has been shown to reduce the nuclear volume of thyroid epithelial cells without causing significant histological changes to the thyroid gland. This compound is valuable for investigating endocrine disorders and related biological processes.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMetallibure is a dithiocarbamoylhydrazine derivative that functions as a gonadotropic function blocker. It effectively inhibits the action of pituitary gonadotropins in teleost fish, subsequently blocking germ cell maturation. Additionally, Metallibure has been shown to reduce the nuclear volume of thyroid epithelial cells without causing significant histological changes to the thyroid gland. This compound is valuable for investigating endocrine disorders and related biological processes.
Product Information
Catalog NumA60705
FormulaC7H14N4S2
Molecular Weight218.34
CAS Number926-93-2
SMILESCNC(NNC(NC(C=C)C)=S)=S
SynonymsICI 33828; Methallibure
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