Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
Lithocholic amide-C2-N(didecane) is a derivative of lithocholic acid designed as an anti-inflammatory agent. This compound exhibits the ability to spontaneously form lipid nanoparticles in aqueous environments, facilitating skin penetration and targeting deeper dermal layers. It demonstrates significant anti-inflammatory activity against psoriasis-like chronic skin conditions by inhibiting keratinocyte proliferation, downregulating mRNA expression of the EphA2 receptor, and reducing serum levels of pro-inflammatory cytokines, including IL-1α, IL-1β, and IFN-γ, through modulation of the Th17/Th2 inflammatory pathway. This makes Lithocholic amide-C2-N(didecane) a valuable tool for researching inflammatory skin disorders. -
Anti-Inflammatory Agent
Anti-inflammatory agent 102 is a selective inhibitor of the ASK1/p38 MAPKs/NF-κB signaling pathway, exerting notable anti-inflammatory effects. It significantly reduces the release of nitric oxide (NO), reactive oxygen species (ROS), and key inflammatory cytokines, including IL-6, TNF-α, and IL-1β. This compound is valuable for research applications focused on inflammatory diseases, particularly ulcerative colitis (UC). -
Anti-inflammatory/hepatoprotective Agent
Isostrictiniin is a polyphenolic compound derived from Nymphaea candida, functioning as an anti-inflammatory and hepatoprotective agent. It enhances the expression of Nrf2 and HO-1 while inhibiting Keap1, leading to the reduction of phosphorylation levels of key proteins such as JNK, ERK1/2, p38, IκBα, and NF-κB p65. Isostrictiniin effectively decreases pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α, and PGE2, demonstrating protective effects against acute lung injury induced by LPS and acute alcoholic liver injury. Its multifaceted activities encompass anti-inflammatory, antioxidant, and anti-fibrotic properties, making it a valuable tool in biochemical research. -
Anti-inflammatory Agent
(E/Z)-3-Hydroxylicochalcone A is a flavonoid with potent anti-inflammatory properties, primarily derived from licorice (Glycyrrhiza inflata and Glycyrrhiza uralensis). This compound effectively inhibits lipid peroxidation in rat liver microsomes and has been shown to reduce the production of reactive oxygen species (ROS), nitric oxide (NO), interleukin-6 (IL-6), and prostaglandin E2 (PGE2) induced by lipopolysaccharide (LPS). Its versatile biological activity makes (E/Z)-3-Hydroxylicochalcone A a valuable reagent for research into oxidative stress and inflammation-related pathways. -
Anti-inflammatory Agent
TNF-α/IL-1β/IL-6-IN-1 is an anti-inflammatory agent that targets pro-inflammatory cytokines. It effectively downregulates the expression of TNF-α, IL-1β, and IL-6, while also inhibiting reactive oxygen species (ROS) production. Additionally, TNF-α/IL-1β/IL-6-IN-1 enhances cholesterol efflux by upregulating ABCG1. This reagent is suitable for research focused on inflammatory and lipid metabolic diseases, including atherosclerosis. -
Anti-inflammatory Agent
Olcorolimus is a derivative of Rapamycin that functions as an anti-inflammatory agent. It effectively reduces levels of IL-4 and IL-5, as well as the presence of eosinophils, neutrophils, and lymphocytes, while also inhibiting cellular fibronectin, lung epithelial cell proliferation, and mucus hypersecretion in Ovalbumin-sensitized BALB/c mice. This compound is valuable for research in the fields of inflammation and immunology, particularly for models related to asthma. -
Anti-Inflammatory Agent
Hedycoronen A is a potent anti-inflammatory agent targeting the inhibition of pro-inflammatory cytokines such as IL-6, IL-12 p40, and TNF-α. It demonstrates effective inhibitory activity in LPS-stimulated bone marrow-derived dendritic cells (BMDCs), with IC50 values of 9.1 μM, 5.6 μM, and 46.0 μM, respectively. This compound is isolated from the plant Hedychium coronarium and is valuable for research focused on inflammatory pathways and therapeutic interventions. -
Inflammatory Cytokine Inhibitor
JTE-607 free base is a selective inhibitor of inflammatory cytokine synthesis, targeting the Cleavage and Polyadenylation Specificity Factor 3 (CPSF3). This compound effectively reduces the production of key inflammatory cytokines, including TNF-α, IL-1β, IL-6, IL-8, and IL-10, in LPS-stimulated human peripheral blood mononuclear cells (PBMCs), achieving IC50 values of 11, 5.9, 8.8, 7.3, and 9.1 nM, respectively. JTE-607 free base demonstrates potential utility in research aimed at understanding and mitigating inflammatory responses, particularly in the context of endotoxin shock. -
Anti-inflammatory Agent
Polyandric acid A is a clerodane diterpenoid identified for its anti-inflammatory properties. It is derived from the Australian medicinal plant D. polyandra and has been shown to inhibit the secretion of pro-inflammatory cytokines. This compound has potential applications in research focused on inflammation-related pathways and therapeutic interventions for inflammatory diseases. -
Anti-inflammatory effect
Hericene A is a phenolic compound derived from Hericium erinaceus, demonstrating potent anti-inflammatory activity. It effectively modulates cytokine secretion, exhibiting moderate inhibition of TNF-α, IL-6, and nitric oxide (NO). This compound is valuable for research into inflammatory pathways and potential therapeutic applications in inflammatory diseases. -
Anti-inflammatory Agent
RPR-106541 is a 17-thiosteroid that functions primarily as an anti-inflammatory agent by exerting potent glucocorticosteroid activity. It has been shown to influence carbohydrate and lipid metabolism, making it relevant for research in metabolic disorders and inflammatory conditions. This compound is useful for studies investigating the mechanisms of inflammation and the modulation of metabolic pathways. -
Anti-inflammatory Agent
CK-17 is a potent anti-inflammatory agent that exhibits oral bioactivity. It effectively inhibits ocular inflammation induced by lens protein, endotoxin, and IL-1, demonstrating approximately twice the potency of Prednisolone in mitigating IL-1-induced responses. This compound serves as a valuable tool for researchers investigating inflammation pathways and potential therapeutic interventions in ocular diseases. -
Anti-inflammatory Pterocarpan
1,11b-Dihydro-11b-hydroxymedicarpin is a pterocarpan derivative known for its anti-inflammatory properties. This compound exerts its biological activity by activating the Notch and Wnt canonical signaling pathways, promoting bone healing and mitigating the effects of arthritis. In preclinical models, it inhibits the expansion of TH17 cells and reduces pro-inflammatory cytokines such as TNF-α, IL-6, and IL-17A, while simultaneously enhancing the anti-inflammatory cytokine IL-10. These characteristics make it a valuable reagent for research applications focused on inflammatory diseases and bone regeneration. -
Anti-inflammatory Agent
Corylin is an orally active flavonoid that functions as an anti-inflammatory agent, primarily targeting IL-6-induced STAT3 signaling. It exhibits multiple biological activities, including anticancer effects and the modulation of hyperlipidemia and insulin resistance. Additionally, Corylin promotes adipocyte browning and enhances lipolysis through SIRT1 or β3-AR-dependent pathways, making it a valuable tool for research in metabolic disorders and inflammation. -
Anti-inflammatory Agent
Bellidifolin is an orally active anti-inflammatory agent that demonstrates antiproliferative and antioxidant properties. It modulates crucial signaling pathways, including STAT3, PI3K-Akt, mTOR, and BRD4, while inhibiting the viral protein R (Vpr). Bellidifolin induces cell cycle arrest and apoptosis, exhibits significant antifibrotic effects, and offers protective benefits to the heart, liver, and nervous system. This compound is valuable for research into diseases such as lung cancer, non-alcoholic fatty liver disease, myocardial hypertrophy, and ischemic cranial nerve injury. -
Anti-Inflammatory Agent
MMPP is an anti-inflammatory agent that primarily targets the inhibition of STAT3 activity. It effectively prevents lipopolysaccharide (LPS)-induced mortality by modulating the inflammatory response. This compound is useful in research focused on understanding the mechanisms of inflammation and developing therapeutic interventions for inflammatory diseases. -
Anti-inflammatory Agent
Anti-inflammatory agent 92 is a porphyrin derivative that functions as an anti-inflammatory agent. This compound demonstrates significant anti-inflammatory properties, particularly in alleviating ulcerative colitis by inhibiting the STAT3-EPHX2 signaling pathway. It is a valuable tool for research into inflammation-related disorders and therapeutic interventions. -
Anti-inflammatory Agent
Fluorofenidone is an orally active anti-inflammatory agent that exhibits anti-fibrotic and antioxidant properties. It functions by downregulating ACSL4 expression, upregulating GPX4, and inhibiting the NF-κB signaling pathway, thereby alleviating inflammation and fibrosis. In preclinical models, Fluorofenidone has demonstrated efficacy in ameliorating cholestasis and fibrosis by modulating the hepatic Erk/Egr-1 signaling and TGFβ1/Smad pathways. This compound is particularly relevant for research into chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF), and non-small cell lung cancer (NSCLC). -
Anti-inflammatory Agent
L-Ornithine 2-oxoglutarate primarily functions as an anti-inflammatory agent. This compound, a salt of amino acids, exhibits antioxidant properties and plays a role in stimulating insulin and growth hormone production. Additionally, L-Ornithine 2-oxoglutarate enhances intracellular amino acid transport, thereby promoting protein synthesis. It is suited for research applications focusing on metabolic disorders, inflammation, and muscle physiology. -
Anti-Inflammatory Agent
IGF-I (30-41) is a fragment of Insulin-like Growth Factor I comprising amino acids 30 to 41, primarily targeting anti-inflammatory pathways. This peptide exhibits significant biological activities, including anabolic, antioxidant, and cytoprotective effects. It is utilized in research applications aimed at understanding inflammation and related pathophysiological conditions. -
Anti-inflammatory Agent
Cinnamtannin D1 is a polyphenolic compound recognized for its anti-inflammatory properties, primarily through its immunosuppressive effects. It modulates the Th17/Treg balance by inhibiting AHR expression, subsequently downregulating p-STAT3/RORγt and promoting Treg differentiation via p-STAT5/Foxp3. Cinnamtannin D1 has demonstrated significant protective effects against apoptosis and oxidative stress in INS-1 cells and primary murine islets exposed to palmitic acid. Its efficacy in the collagen-induced arthritis model underscores its potential for research in rheumatoid arthritis. -
Anti-inflammatory/Anticancer/Neuroprotective Agent
5-OH-HxMF is a hydroxylated polymethoxyflavone that exhibits significant anti-inflammatory and anticancer properties. Additionally, it demonstrates neuroprotective and neurotrophic activities, making it a valuable reagent for research in inflammation, cancer biology, and neurodegenerative diseases. Its multifaceted biological effects support its use in studies aimed at understanding and developing therapies for various pathologies. -
Anti-Inflammatory Agent
Picrasidine I is a dimeric alkaloid known for its anti-inflammatory properties, primarily acting through the modulation of key signaling pathways. It induces cell cycle arrest and apoptosis by downregulating the ERK and Akt pathways. Additionally, Picrasidine I inhibits the activation of MAPKs and NF-κB, reduces reactive oxygen species generation, and suppresses the expression of c-Fos and NFATc1, making it a valuable tool for research in inflammation and osteoclastogenesis. -
Anti-inflammatory Agent/Anticancer Agent
Cryptolepine is a multi-potent alkaloid that serves as an anti-inflammatory and anticancer agent. It functions primarily as an inhibitor of c-Myc, mTOR, NF-κB, HIF-1, and MAPK while activating AMPKα1/2, leading to various biological effects including DNA intercalation and inhibition of topoisomerase II. These activities result in disrupted mitochondrial dynamics and induction of apoptosis in cancer cells. Cryptolepine shows promise in research applications focusing on tumors such as melanoma and hepatocellular carcinoma, as well as in studies related to malaria, inflammatory diseases, and diabetes. -
Anti-Inflammatory Compounds
Anti-inflammatory agent 47 is a potent anti-inflammatory and antioxidant compound that targets inflammatory pathways. It inhibits the release of intracellular reactive oxygen species (ROS) and nitric oxide (NO), thereby suppressing neuronal apoptosis through the modulation of inflammatory and apoptotic signaling cascades. This compound is applicable in research focused on neurodegenerative diseases, particularly Parkinson's Disease (PD). -
Anticancer/Anti-inflammatory Agent
Perezone is a sesquiterpenoid benzoquinone derived from the roots of Acourtia species, acting as an anticancer and anti-inflammatory agent. It effectively inhibits the proliferation of leukemia cell line K-562 and human glioma cell line U-251, with an IC50 of 6.83 μM. Furthermore, Perezone upregulates the expression of apoptosis-related genes, including caspase 3, 8, and 9, while also exhibiting significant antioxidant and anti-inflammatory properties. This compound is of interest in cancer research and potential therapeutic applications. -
Antitumor/Anti-inflammatory Agent
Antitumor agent-56 is a triptolide derivative that functions primarily as an antitumor and anti-inflammatory agent. This compound demonstrates significant inhibitory effects on melanoma proliferation while also exhibiting nitric oxide release activities. Antitumor agent-56 is suitable for various research applications in cancer biology and therapeutic development. -
Anti-Inflammatory Agent
2,4′-Dihydroxybenzophenone acts as an anti-inflammatory agent by targeting the hydrophobic pocket of MD2, effectively inhibiting the dimerization of TLR4. This compound demonstrates significant biological activity by suppressing LPS-induced mitochondrial reactive oxygen species (mtROS) production and attenuating the inflammatory response through downregulation of pro-inflammatory mediators, including MyD88, p-IRAK4, and NF-κB. Additionally, 2,4′-Dihydroxybenzophenone serves as an effective UV absorber, enhancing its utility in research on oxidative stress and inflammation. -
Anti-inflammatory Agent
Regaloside C is an anti-inflammatory agent that exhibits antioxidant properties by scavenging ABTS and DPPH free radicals. It targets multiple molecular pathways, including TNF-α, MMP-2, ERα, AKT1, TLR4, and HSP90-α. This compound is relevant for research focused on inflammatory diseases and may provide insights into therapeutic approaches for managing chronic inflammation. -
Antioxidant/Anti-inflammatory Agent
Pinus pinaster bark extract serves as a potent antioxidant and anti-inflammatory agent. This extract demonstrates neuroprotective effects by enhancing the activity of toll-like receptors (TLR), leading to increased production of interleukin-10 (IL-10). It is utilized in research applications focused on inflammatory responses and neurodegenerative diseases, making it a valuable tool for understanding cellular protection mechanisms. -
Anti-Inflammatory Agent
4-Methoxylonchocarpin is an orally active anti-inflammatory agent that primarily targets Toll-like Receptor 4 (TLR4). This compound effectively inhibits the binding of lipopolysaccharides (LPS) to TLR4, leading to the suppression of NF-κB activation and the downregulation of pro-inflammatory cytokines such as TNF and IL-6. Additionally, 4-Methoxylonchocarpin reduces the phosphorylation of TGF-beta activated kinase 1 and mitigates the expression of IL-1β, IL-17A, and TNF in a 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model, demonstrating its potential in anti-inflammatory research applications. -
Anti-inflammatory Agent
Chlojaponilactone B is a lindenane-type sesquiterpenoid known for its anti-inflammatory properties. This compound functions by inhibiting Toll-like receptor 4 (TLR4), leading to a decrease in reactive oxygen species (ROS) production and downregulation of the NF-κB pathway. Consequently, it reduces the expression of pro-inflammatory cytokines, including iNOS, nitric oxide (NO), COX-2, IL-6, and TNF-α. Chlojaponilactone B is a valuable tool for research into inflammation and related pathways. -
Anti-inflammatory Agent
Ganglioside GD1a functions as an anti-inflammatory agent by modulating the toxic effects induced by E. coli lipopolysaccharide (LPS). It prevents the translocation of TLR4 into lipid rafts, thereby reducing LPS-induced cytotoxicity and the production of reactive oxygen species. Ganglioside GD1a is valuable for research applications focused on inflammatory signaling and cellular response mechanisms. -
Inflammatory Corpuscles Inhibitor
JC2-11 is an inhibitor of inflammatory corpuscles that targets domain-containing proteins NLRC4 and AIM2, as well as non-canonical inflammatory pathways. This compound is effective in reducing the secretion of caspase-1 (p20) and the cleavage of gasdermin D (GSDMD), leading to decreased release of IL-1β and lactate dehydrogenases (LDH) from inflammatory bodies. JC2-11 also disrupts the activation of inflammatory corpuscles by inhibiting reactive oxygen species production and caspase-1 activity, making it a valuable tool for research into inflammation and related diseases. -
Anti-inflammatory Agent
Maresin 2 is a pro-resolving mediator derived from human macrophages, primarily acting as an anti-inflammatory agent. This compound belongs to the maresin family of lipid mediators, biosynthesized from docosahexaenoic acid (DHA). Maresin 2 plays a crucial role in tissue inflammation resolution and has potential applications in research focused on inflammatory diseases and regenerative medicine. -
Anti-inflammatory Agent
Dihydromyristicin is a plant-derived flavonoid known for its potent anti-inflammatory effects. It exerts its biological activity by attenuating endotoxic inflammation through the suppression of reactive oxygen species (ROS)-mediated activation of the PI3K/Akt/NF-κB signaling pathways. This compound is valuable in research applications focusing on inflammation-related studies and potential therapeutic interventions. -
Anti-Inflammatory Agent
Linocinnamarin is a natural product derived from Fragaria ananassa Duch and functions as an anti-inflammatory agent. It demonstrates significant anti-inflammatory activity by inhibiting the antigen-stimulated increase in intracellular free Ca2+ concentration and the production of reactive oxygen species (ROS). This compound is valuable for research applications focused on inflammation pathways and the potential therapeutic effects of natural anti-inflammatory substances. -
Dual-target Anti-inflammatory Peptide
Pegtarazimod is a dual-target anti-inflammatory peptide that regulates both the complement system and neutrophil-associated inflammatory pathways. It demonstrates significant biological activity by reducing reactive oxygen species (ROS) production and lowering neutrophil elastase levels in vivo, thereby mitigating inflammatory responses. Pegtarazimod has shown improved survival rates in multiple in vivo models of acute graft-versus-host disease (aGVHD) and exhibits efficacy against herpes simplex virus type 1 infections by inhibiting the activation of the C1 complex. This reagent is applicable in research focused on aGVHD, acute pulmonary diseases, and skin infections caused by herpes simplex virus type 1. -
Antiinflammatory Agent
Timosaponin E2 is an anti-inflammatory agent that functions by inhibiting the production of reactive oxygen species. This compound demonstrates significant potential in modulating inflammatory responses, making it valuable for research in oxidative stress-related diseases and therapeutic exploration. Its biochemical properties make it a suitable candidate for further investigation in the development of anti-inflammatory therapies. -
Anti-inflammatory Agent
Zaluzanin C is a sesquiterpene lactone that acts as an anti-inflammatory agent. It exhibits significant anti-inflammatory activity by inhibiting mitochondrial reactive oxygen species (mtROS) production and blocking the NF-κB signaling pathway, leading to a reduction in TNF-α levels. Additionally, Zaluzanin C has been shown to prevent the differentiation of 3T3-L1 preadipocytes into mature adipocytes, making it a valuable reagent for research in inflammation and adipogenesis. -
Anti-inflammatory Agent
8-Deoxylactucin is an orally active sesquiterpene lactone that functions as an anti-inflammatory agent by inhibiting LPS-induced nitric oxide production in RAW264.7 macrophages, with an IC50 of 4.35 μM. It exerts its effects primarily by blocking the NF-κB signaling pathway. Additionally, 8-Deoxylactucin has demonstrated hepatoprotective properties in a murine model of acute hepatitis induced by LPS and D-galactosamine. This compound is valuable for research on inflammatory diseases and liver injury mechanisms. -
Anti-inflammatory Agent
Artocarpesin is a flavonoid compound that acts as an anti-inflammatory agent. It exhibits inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA) by downregulating the production of nitric oxide (NO), prostaglandin E2 (PGE2), and reactive oxygen species (ROS) through the inhibition of COX-2 and iNOS expression. Additionally, Artocarpesin impedes platelet aggregation via the modulation of cyclic nucleotides and MAPK pathways, making it a valuable reagent for research in cardiovascular diseases and inflammation-related studies. -
Anti-inflammatory Agent
NLRP3-IN-72 is a benzimidazole derivative that functions as an anti-inflammatory agent by specifically targeting the NLRP3 inflammasome. It demonstrates significant biological activity with an IC50 of 0.3 μM for inhibiting NLRP3-mediated IL-1β secretion, a PD50 of 0.4 μM for protecting against pyroptosis, and an EC50 of 0.6 μM for the induction of heme oxygenase-1 (HO-1). These properties make NLRP3-IN-72 a valuable tool for research into inflammatory processes and potential therapeutic interventions. -
Anti-inflammatory Agent
Macarangin is an anti-inflammatory agent isolated from propolis. It exhibits significant DPPH radical-scavenging activity and demonstrates anti-inflammatory effects by inhibiting the activation of the NLRP3 inflammasome. This compound is valuable for research applications focused on inflammation pathways and oxidative stress. -
Anti-inflammatory Agent
Sulindac sodium is an orally active nonsteroidal anti-inflammatory agent that exerts its effects through the inhibition of cyclooxygenase enzymes, leading to decreased prostaglandin synthesis. This compound demonstrates significant anti-inflammatory and immunomodulatory properties, making it valuable for investigating conditions such as arthritis, gout, and various cancers including colorectal cancer (CRC) and lung cancer. Its diverse mechanisms of action and potential therapeutic applications contribute to its utility in cancer and inflammation research. -
Inflammatory Cytokine Inhibitor
JTE-607 is a selective inhibitor targeting the Cleavage and Polyadenylation Specificity Factor 3 (CPSF3), demonstrating potent suppression of inflammatory cytokine synthesis. This compound effectively reduces the production of key inflammatory cytokines, including TNF-α, IL-1β, IL-6, IL-8, and IL-10 in LPS-stimulated human peripheral blood mononuclear cells (PBMCs) with IC50 values of 11, 5.9, 8.8, 7.3, and 9.1 nM, respectively. JTE-607 is utilized in research applications focused on understanding and mitigating inflammatory responses and endotoxin shock. -
Anti-inflammatory Agent
Hydrocortisone hemisuccinate is a glucocorticoid steroid that acts as an anti-inflammatory agent, exhibiting significant immunomodulatory properties. It effectively inhibits the bioactivity of interleukin-6 (IL-6) and interleukin-3 (IL-3) with IC50 values of 6.7 μM and 21.4 μM, respectively. This compound is applicable in research focused on ulcerative colitis and recurrent oral ulcers, providing a valuable tool for studying inflammatory conditions and potential therapeutic interventions. -
Anti-Inflammatory Agent
Magnesium sulfate is an effective anti-inflammatory agent and a potent inhibitor of L-type calcium channels. It exhibits diverse biological activities including anticonvulsant, vasodilatory, and neuroprotective effects. This compound is commonly utilized in research related to conditions such as preeclampsia and eclampsia, providing valuable insights into therapeutic interventions and underlying mechanisms of these disorders. -
Anti-inflammatory Agent
Lipoxin A4 (LXA4) is an endogenous eicosanoid mediator with significant anti-inflammatory and pro-resolving activity. It modulates inflammatory responses by inhibiting proliferation and cytokine/chemokine production in human epidermal keratinocytes through the ERK1/2 and NF-kB signaling pathways. Additionally, Lipoxin A4 effectively reduces serum amyloid A (SAA)-induced IL-8 release, demonstrating an IC50 of 25.74 nM. This compound serves as a valuable tool for research in inflammation and resolution processes. -
Anti-inflammatory Agent
Lauroyl-L-carnitine chloride is an anti-inflammatory agent that acts as an orally active metabolite. It has been shown to significantly enhance the expression of the anti-inflammatory cytokine IL-10, thereby exerting beneficial effects in inflammatory conditions. Research indicates that Lauroyl-L-carnitine chloride may alleviate symptoms associated with Crohn's-like colitis, making it a valuable tool for studying inflammatory bowel disease.
