Lithocholic amide-C2-N(didecane) is a derivative of lithocholic acid designed as an anti-inflammatory agent. This compound exhibits the ability to spontaneously form lipid nanoparticles in aqueous environments, facilitating skin penetration and targeting deeper dermal layers. It demonstrates significant anti-inflammatory activity against psoriasis-like chronic skin conditions by inhibiting keratinocyte proliferation, downregulating mRNA expression of the EphA2 receptor, and reducing serum levels of pro-inflammatory cytokines, including IL-1α, IL-1β, and IFN-γ, through modulation of the Th17/Th2 inflammatory pathway. This makes Lithocholic amide-C2-N(didecane) a valuable tool for researching inflammatory skin disorders.
Lithocholic amide-C2-N(didecane) is a derivative of lithocholic acid designed as an anti-inflammatory agent. This compound exhibits the ability to spontaneously form lipid nanoparticles in aqueous environments, facilitating skin penetration and targeting deeper dermal layers. It demonstrates significant anti-inflammatory activity against psoriasis-like chronic skin conditions by inhibiting keratinocyte proliferation, downregulating mRNA expression of the EphA2 receptor, and reducing serum levels of pro-inflammatory cytokines, including IL-1α, IL-1β, and IFN-γ, through modulation of the Th17/Th2 inflammatory pathway. This makes Lithocholic amide-C2-N(didecane) a valuable tool for researching inflammatory skin disorders.
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