Lipoxin A4 (LXA4) is an endogenous eicosanoid mediator with significant anti-inflammatory and pro-resolving activity. It modulates inflammatory responses by inhibiting proliferation and cytokine/chemokine production in human epidermal keratinocytes through the ERK1/2 and NF-kB signaling pathways. Additionally, Lipoxin A4 effectively reduces serum amyloid A (SAA)-induced IL-8 release, demonstrating an IC50 of 25.74 nM. This compound serves as a valuable tool for research in inflammation and resolution processes.
Lipoxin A4 (LXA4) is an endogenous eicosanoid mediator with significant anti-inflammatory and pro-resolving activity. It modulates inflammatory responses by inhibiting proliferation and cytokine/chemokine production in human epidermal keratinocytes through the ERK1/2 and NF-kB signaling pathways. Additionally, Lipoxin A4 effectively reduces serum amyloid A (SAA)-induced IL-8 release, demonstrating an IC50 of 25.74 nM. This compound serves as a valuable tool for research in inflammation and resolution processes.
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