JTE-607 is a selective inhibitor targeting the Cleavage and Polyadenylation Specificity Factor 3 (CPSF3), demonstrating potent suppression of inflammatory cytokine synthesis. This compound effectively reduces the production of key inflammatory cytokines, including TNF-α, IL-1β, IL-6, IL-8, and IL-10 in LPS-stimulated human peripheral blood mononuclear cells (PBMCs) with IC50 values of 11, 5.9, 8.8, 7.3, and 9.1 nM, respectively. JTE-607 is utilized in research applications focused on understanding and mitigating inflammatory responses and endotoxin shock.
JTE-607 is a selective inhibitor targeting the Cleavage and Polyadenylation Specificity Factor 3 (CPSF3), demonstrating potent suppression of inflammatory cytokine synthesis. This compound effectively reduces the production of key inflammatory cytokines, including TNF-α, IL-1β, IL-6, IL-8, and IL-10 in LPS-stimulated human peripheral blood mononuclear cells (PBMCs) with IC50 values of 11, 5.9, 8.8, 7.3, and 9.1 nM, respectively. JTE-607 is utilized in research applications focused on understanding and mitigating inflammatory responses and endotoxin shock.
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