Cinnamtannin D1 is a polyphenolic compound recognized for its anti-inflammatory properties, primarily through its immunosuppressive effects. It modulates the Th17/Treg balance by inhibiting AHR expression, subsequently downregulating p-STAT3/RORγt and promoting Treg differentiation via p-STAT5/Foxp3. Cinnamtannin D1 has demonstrated significant protective effects against apoptosis and oxidative stress in INS-1 cells and primary murine islets exposed to palmitic acid. Its efficacy in the collagen-induced arthritis model underscores its potential for research in rheumatoid arthritis.
Cinnamtannin D1 is a polyphenolic compound recognized for its anti-inflammatory properties, primarily through its immunosuppressive effects. It modulates the Th17/Treg balance by inhibiting AHR expression, subsequently downregulating p-STAT3/RORγt and promoting Treg differentiation via p-STAT5/Foxp3. Cinnamtannin D1 has demonstrated significant protective effects against apoptosis and oxidative stress in INS-1 cells and primary murine islets exposed to palmitic acid. Its efficacy in the collagen-induced arthritis model underscores its potential for research in rheumatoid arthritis.
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