JTE-607 free base is a selective inhibitor of inflammatory cytokine synthesis, targeting the Cleavage and Polyadenylation Specificity Factor 3 (CPSF3). This compound effectively reduces the production of key inflammatory cytokines, including TNF-α, IL-1β, IL-6, IL-8, and IL-10, in LPS-stimulated human peripheral blood mononuclear cells (PBMCs), achieving IC50 values of 11, 5.9, 8.8, 7.3, and 9.1 nM, respectively. JTE-607 free base demonstrates potential utility in research aimed at understanding and mitigating inflammatory responses, particularly in the context of endotoxin shock.
JTE-607 free base is a selective inhibitor of inflammatory cytokine synthesis, targeting the Cleavage and Polyadenylation Specificity Factor 3 (CPSF3). This compound effectively reduces the production of key inflammatory cytokines, including TNF-α, IL-1β, IL-6, IL-8, and IL-10, in LPS-stimulated human peripheral blood mononuclear cells (PBMCs), achieving IC50 values of 11, 5.9, 8.8, 7.3, and 9.1 nM, respectively. JTE-607 free base demonstrates potential utility in research aimed at understanding and mitigating inflammatory responses, particularly in the context of endotoxin shock.
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