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Catalog No.
Product Name
Application
Product Information
Citations
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NO/PGE2 Inhibitor
Epibetulinic acid is an inhibitor of nitric oxide (NO) and prostaglandin E2 (PGE2) production. It demonstrates significant anti-inflammatory activity, exhibiting IC50 values of 0.7 μM for NO and 0.6 μM for PGE2 in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin. This compound is valuable for research applications focused on inflammation and immune response modulation. -
5-LO/PGE2 Inhibitor
Canniprene is a potent inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE2), with IC50 values of 0.4 μM and 10 μM, respectively. Derived from Cannabis sativa, Canniprene modifies the biosynthesis of inflammatory eicosanoids and prostaglandins, making it a valuable tool for researching inflammation and related pathways. Its unique mechanism of action positions Canniprene as a potential candidate for studying inflammatory diseases and therapeutic interventions targeting lipid mediators. -
PGE2 Inhibitor
Saikogenin D is an effective PGE2 inhibitor isolated from Bupleurum chinense. This compound exhibits significant anti-inflammatory properties by activating epoxygenases, leading to the conversion of arachidonic acid into epoxyeicosanoids and dihydroxyeicosatrienoic acids, which subsequently suppress PGE2 production. Saikogenin D also induces an increase in intracellular calcium levels ([Ca2+]i) through the release of Ca2+ from intracellular stores, making it a valuable tool for studying inflammatory pathways. -
COX-2 Inhibitor
Apricoxib is a selective inhibitor of cyclooxygenase-2 (COX-2), demonstrating a potent inhibitory effect on PGE2 production with an IC50 of 1.5 nM. This compound exhibits notable biological activities, including anticancer, analgesic, and anti-inflammatory properties. Apricoxib is a valuable tool for research applications focused on inflammation, pain management, and cancer therapeutics. -
PGE2 Inhibitor
(+)-Oxypeucedanin methanolate is a potent inhibitor of prostaglandin E2 (PGE2) synthesis. This natural compound exhibits significant anti-inflammatory properties, making it a valuable reagent in studies focused on inflammation and pain modulation. Research applications include investigating the pathways of prostaglandin synthesis and exploring potential therapeutic interventions for inflammatory diseases. -
NO/PGE2 Inhibitor
Salviifoside A is a phenolic glycoside that acts as an inhibitor of nitric oxide (NO) and prostaglandin E2 (PGE2) production. Isolated from the leaves of Alangium salviifolium, Salviifoside A effectively suppresses LPS-induced nitric oxide and prostaglandin E2 production in macrophages while maintaining cell viability. This compound is valuable for research focused on inflammatory responses and the modulation of macrophage activation. -
KRASG12C Inhibitor
KRASG12C IN-12 is a selective inhibitor of the KRASG12C mutant. This compound effectively forms a ternary complex with intracellular cyclophilin A (CYPA) and the activated KRASG12C, inhibiting its downstream signaling pathways. It has significant potential for research applications related to cancer biology, particularly in studies targeting KRAS-driven tumorigenesis. -
NO Production Inhibitor
N-Phthaloyl-L-glutamic acid is a nitric oxide production inhibitor that effectively reduces lipopolysaccharide (LPS)-induced nitric oxide synthesis in murine spleen cells. This compound serves as a potential anti-inflammatory agent, demonstrating low cytotoxicity in vitro against tumor cells and in BALB/c mice spleen cell cultures. N-Phthaloyl-L-glutamic acid is suitable for research investigating mechanisms of inflammation and associated therapeutic approaches. -
NO Inhibitor
Carboxy-PTIO potassium is a potent nitric oxide (NO) inhibitor that facilitates the rapid reaction with NO to yield nitrogen dioxide (NO2). This compound exhibits significant biological activity by preventing hypotension and alleviating endotoxic shock, particularly in lipopolysaccharide-stimulated rat models. It serves as a valuable reagent for researchers investigating the role of nitric oxide in various physiological and pathophysiological processes. -
NO Synthase Inhibitor
L-Canavanine sulfate is a selective inhibitor of inducible nitric oxide synthase (iNOS). It demonstrates significant inhibition of nitric oxide production, making it a valuable tool for studying inflammatory pathways and the role of iNOS in various disease models. This compound is utilized in research applications focused on neurodegeneration, cancer, and cardiovascular disease, providing insights into the mechanisms of nitric oxide-mediated signaling. -
iNOS Inhibitor
Asperuloside is an iridoid compound derived from Hedyotis diffusa, primarily known for its role as an inducible nitric oxide synthase (iNOS) inhibitor. This compound exhibits notable anti-inflammatory properties by suppressing the NF-κB and MAPK signaling pathways. Asperuloside is valuable in studying inflammatory processes and developing therapeutic strategies for related diseases. -
CaV1.2 Channel Inhibitor
Demethylsuberosin, a coumarin derivative isolated from Angelica gigas Nakai, primarily targets the L-type CaV1.2 channel as an inhibitor. This compound demonstrates significant antihypertensive effects, in addition to possessing antioxidant and anti-inflammatory properties. Notably, Demethylsuberosin offers neuroprotective effects against glutamate-induced cytotoxicity in primary cultured rat cortical cells, making it a valuable reagent for research in cardiovascular and neurological studies. -
iNOS Inhibitor
GW274150 phosphate is a selective, orally active inhibitor of inducible nitric oxide synthase (iNOS), demonstrating potent inhibition with an IC50 of 2.19 μM and a Kd of 40 nM in human iNOS, as well as an ED50 of 1.15 μM in rat iNOS. This compound exhibits reduced potency against endothelial and neuronal NOS isoforms. GW274150 phosphate has been shown to provide protective effects in models of acute lung injury and inflammation, making it a valuable tool for researchers studying inflammatory responses and related pathways. -
NO Synthase Inhibitor
Kuwanon A is a flavone derivative that serves as an inhibitor of nitric oxide synthase. It effectively reduces nitric oxide production with an IC50 of 10.5 μM. This compound is relevant for research applications investigating vascular function, inflammatory processes, and the pathophysiology of various diseases linked to nitric oxide signaling. -
NOS Inhibitor
S-MTC dihydrochloride is a selective inhibitor of type I nitric oxide synthase (NOS). It effectively reduces nitric oxide production, making it a valuable tool for studies investigating the role of NOS in various physiological and pathological processes. This compound is commonly utilized in research applications related to cardiovascular health, neurobiology, and inflammation. -
nNOS Inhibitor
Nω-Propyl-L-arginine is a highly selective and potent competitive inhibitor of neuronal nitric oxide synthase (nNOS), exhibiting a Ki value of 57 nM. With a 149-fold selectivity for nNOS over endothelial nitric oxide synthase (eNOS), this compound is invaluable for studying nNOS-related pathways and neurobiology. Its use is pertinent in elucidating the role of nNOS in various physiological and pathological processes, making it a crucial reagent for research applications in neuroscience and pharmacology. -
nitric oxide synthase Inhibitor
Aminopicoline is a potent and non-selective inhibitor of nitric oxide synthase (NOS) isoenzymes, including iNOS, nNOS, and eNOS. By competing with arginine at the substrate-binding site, it effectively reduces cellular nitric oxide production and inhibits the elevation of plasma nitrate levels, which can influence mean arterial pressure. This compound serves as a valuable tool in research focused on diseases related to septic shock, joint and intestinal inflammation, as well as central nervous system (CNS) inflammation. -
NOS3 Inhibitors
Kihadanin A is a limonoid that functions as an inhibitor of nitric oxide synthase 3 (NOS3). Isolated from the methanol extract of Dictamnus dasycarpus root bark, Kihadanin A demonstrates potential therapeutic applications in the study of hyperuricemia (HUA). This compound can be utilized in research aimed at understanding the biochemical pathways related to nitric oxide production and its implications in various physiological conditions. -
NOS Inhibitor
nNOS-IN-1 is a selective inhibitor of nitric oxide synthases (NOS), demonstrating potent inhibitory activity against neuronal, inducible, and endothelial NOS with IC50 values of 2.5, 5.7, and 13 μM, respectively. This compound serves as a valuable tool for elucidating the roles of nitric oxide in various biological processes and has potential applications in neurobiology and cardiovascular research. By selectively targeting NOS, nNOS-IN-1 can aid in the investigation of pathological conditions associated with dysregulated nitric oxide signaling. -
nNOS Inhibitor
Nω-Propyl-L-arginine hydrochloride is a selective inhibitor of neuronal nitric oxide synthase (nNOS), exhibiting a competitive inhibition profile with a Ki value of 57 nM. This compound offers significant selectivity, displaying a 149-fold preference for nNOS over endothelial nitric oxide synthase (eNOS). Nω-Propyl-L-arginine hydrochloride is primarily utilized in research applications focused on the modulation of nitric oxide pathways and the study of nNOS-related physiological and pathological processes. -
NO Synthase Inhibitor
2-Iminobiotin hydrobromide is a reversible inhibitor of nitric oxide synthase (NOS), specifically exhibiting Kis of 21.8 μM for murine inducible NOS (iNOS) and 37.5 μM for rat neuronal NOS (n-cNOS). This compound has demonstrated potential neuroprotective effects, providing protection to human neuronal cells against hypoxia-induced cell damage. It is valuable for research in neurobiology and the study of nitric oxide signaling pathways. -
iNOS Inhibitor
AR-C102222 hydrochloride is a selective inhibitor of inducible nitric oxide synthase (iNOS) with a competitive mechanism of action. Demonstrating an IC50 of 37 nM, it exhibits notable antinociceptive and anti-inflammatory properties. This compound is valuable for research into pain modulation and inflammatory diseases, providing insights into the role of nitric oxide in these biological processes. -
iNOS Inhibitor
BBS-4 is a highly potent and selective inhibitor of inducible nitric oxide synthase (iNOS, NOS2) dimerization, demonstrating an IC50 of 0.49 nM. This compound is primarily utilized in research focused on cardiovascular dysfunction, notably offering protective effects in murine models of sepsis. Its selective inhibition of iNOS makes BBS-4 a valuable tool for investigating nitric oxide-related pathologies and potential therapeutic interventions. -
nNOS Inhibitor
NOS1-IN-1 is a selective and cell-permeable inhibitor of neuronal nitric oxide synthase (nNOS), displaying a Ki of 120 nM. This compound demonstrates significant selectivity, with a 2617-fold preference over endothelial nitric oxide synthase (eNOS) and a 325-fold selectivity over inducible nitric oxide synthase (iNOS), evidenced by Ki values of 39 μM and 325 μM, respectively. NOS1-IN-1 is valuable for research on neurological disorders, including cerebral palsy, by enabling the exploration of nNOS-related pathways in disease mechanisms. -
NO Synthase Inhibitor
NOS-IN-1 is a potent and orally bioavailable inhibitor of nitric oxide synthase (NOS) isoforms, demonstrating inhibitory constants (IC50) of 0.1 μM for human inducible NOS (hiNOS), 1.1 μM for endothelial NOS (heNOS), and 0.2 μM for neuronal NOS (hnNOS). This compound is valuable for studying nitric oxide signaling pathways and exploring therapeutic options in diseases associated with dysregulated nitric oxide levels, such as cardiovascular disorders and neurodegenerative diseases. Its selective inhibition of NOS isoforms can aid in elucidating the specific roles of nitric oxide in various biological processes. -
NOS Inhibitor
TRIM is a potent nitric oxide synthase (NOS) inhibitor, selectively targeting neuronal nitric oxide synthase (nNOS) in mouse cerebellar samples and inducible nitric oxide synthase (iNOS) in rat lung tissues, with IC50 values of 28.2 µM and 27.0 µM, respectively. This compound exhibits significant antidepressant and anxiolytic-like properties, making it valuable for research into depression and anxiety disorders. TRIM serves as an important tool for investigations into NOS-related pathways and their implications in neuropsychiatric conditions. -
SPSB2-iNOS Inhibitor
SPSB2-iNOS inhibitory cyclic peptide-1 is a potent inhibitor targeting the interaction between SPSB2 and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity (KD) of 4.4 nM. This cyclic peptide demonstrates resistance to proteolytic degradation by pepsin, trypsin, and α-chymotrypsin, ensuring stability in biological environments. Additionally, it maintains stability in human plasma and oxidative conditions, making it a valuable tool for studying iNOS-related pathways in inflammation and other biological processes. -
iNOS/Nf-Κb Inhibitor
Hymenoxin is a dual inhibitor of inducible nitric oxide synthase (iNOS) and nuclear factor kappa B (NF-κB), exhibiting IC50 values of 42.7 μM and 85.5 μM, respectively. This compound demonstrates the capacity to reduce oxidative stress by 16% at a concentration of 125 μg/mL. Hymenoxin is primarily utilized in research focused on inflammatory responses and related signaling pathways. Its inhibitory effects on key regulators make it valuable for studies investigating the roles of iNOS and NF-κB in various disease models. -
NOS Inhibitor
Vinyl-L-NIO hydrochloride is a selective inhibitor of nitric oxide synthase (NOS), effectively reducing nitric oxide production. By targeting the NOS enzyme, this compound serves as a valuable tool for investigating the role of nitric oxide in various biological processes. Its application extends to studies related to cardiovascular function, neurobiology, and inflammation research. -
NOS1Inhibitor
ARL 17477 is a dual inhibitor targeting neuronal nitric oxide synthase (NOS1) and the autophagy-lysosomal system. This compound exhibits significant anticancer activity and effectively inhibits tumor growth, particularly in KRAS-mutated cancers. Its potential applications include studies on cancer progression and therapeutic resistance, making it a valuable tool in cancer research. -
NO Synthase Inhibitor
Asymmetric dimethylarginine dihydrochloride is a potent inhibitor of nitric oxide synthase (NOS). By decreasing nitric oxide (NO) production, it plays a significant role in the study of endothelial dysfunction and related cardiovascular diseases. This compound is instrumental in research focused on elucidating the pathways involved in vascular health and hypertension. -
NOS Inhibitor
1,4-PBIT dihydrobromide is a potent inhibitor of nitric oxide synthases (NOS), demonstrating Ki values of 7.6 nM for inducible NOS (iNOS), 360 nM for endothelial NOS (eNOS), and 16 nM for neuronal NOS (nNOS). This compound serves as a valuable tool for investigating nitric oxide signaling pathways and assessing the role of NOS in various biological contexts. It is applicable in studies related to inflammation, neurobiology, and cardiovascular research. -
iNOS Inhibitor
AE-ITU dihydrobromide is a selective inhibitor of inducible nitric oxide synthase (iNOS). This compound has been shown to attenuate liver dysfunction induced by endotoxaemia in rat models, demonstrating its potential in studies related to inflammatory responses and liver pathology. AE-ITU dihydrobromide is valuable for researchers investigating the role of nitric oxide in various biological processes and therapeutic interventions. -
NO Synthase Inhibitor
Curvularin is a potent inhibitor of inducible nitric oxide synthase (iNOS), demonstrating a half-maximal inhibitory concentration (IC50) of 9.5 µM. Isolated from the fungus Curvularia lunata, this mycotoxin is utilized in research to explore its effects on nitric oxide production in inflammatory responses. Curvularin's unique properties make it a valuable tool for investigating various biological processes and therapeutic applications related to iNOS inhibition. -
iNOS Inhibitor
L-NIL hydrochloride is a selective inhibitor of inducible nitric oxide synthase (iNOS), demonstrated to have an IC50 of 3.3 μM in murine models. By inhibiting iNOS, L-NIL hydrochloride effectively reduces the production of nitric oxide, a key mediator in various inflammatory processes. This compound is utilized in research focused on inflammation, neurodegeneration, and associated pathologies where modulation of nitric oxide levels is critical. -
iNOS Inhibitor
AMT hydrochloride is a selective inhibitor of inducible nitric oxide synthase (iNOS), with a Ki value of 4.2 nM. This compound effectively modulates nitric oxide production, making it a valuable tool for studying inflammatory responses and related signaling pathways. It is applicable in research examining the role of iNOS in various physiological and pathological conditions. -
NOS Inhibitor
D-NAME hydrochloride is a potent nitric oxide synthase (NOS) inhibitor. By inhibiting NOS activity, D-NAME hydrochloride effectively reduces nitric oxide production, making it a valuable tool for studying the role of nitric oxide in various physiological and pathological processes. This reagent can be applied in research related to cardiovascular disease, neurodegeneration, and inflammatory responses. -
Nonenzyme Glycation Inhibitor
Flazin is a non-enzymatic protein glycation inhibitor that targets glycation processes and peroxynitrite (ONOO-). It exhibits an IC50 value of 85.31 μM in inhibiting bovine serum albumin (BSA) glycation and an EC50 value of 71.99 μM for ONOO-. Flazin is valuable in research related to diabetes and neurodegenerative disorders and functions as a lipid droplet regulator, making it relevant for studies on lipid metabolism disorders. Additionally, it serves as an inhibitor of xanthine oxidase (XOD), further expanding its utility in various biochemical applications. -
NO Inhibitor
Carboxy-PTIO is a highly effective nitric oxide (NO) scavenger, facilitating the rapid reaction with NO to generate nitrogen dioxide (NO2). This compound demonstrates significant biological activity in preventing hypotension and endotoxic shock, particularly in lipopolysaccharide-stimulated rat models. Carboxy-PTIO serves as a valuable tool in research focused on the roles of nitric oxide in various physiological and pathological processes. -
NO Synthase Inhibitor
Syzalterin is a potent inhibitor of nitric oxide synthase, demonstrating an IC50 value of 1.87 μg/mL. This compound effectively reduces NO production, making it valuable for research focused on nitric oxide-related signaling pathways and their implications in various physiological and pathological processes. Syzalterin can be utilized in studies exploring cardiovascular function, neurobiology, and inflammatory responses. -
NO Synthase Inhibitor
Cauloside C is a triterpene glycoside that acts as an inhibitor of nitric oxide synthase (NOS). It demonstrates significant anti-inflammatory properties by reducing the expression of inducible nitric oxide synthase (iNOS) and downregulating proinflammatory cytokines. This compound is a valuable tool for research focused on inflammation and related signaling pathways. -
NO Inhibitor
Futoquinol is a neolignan that acts as a nitric oxide (NO) inhibitor, derived from the dried aerial parts of Piper kadsura. This compound demonstrates potent inhibition of NO production in microglial cells, highlighting its potential in modulating neuroinflammatory processes. Futoquinol is valuable for research applications focused on neuroinflammation and related neurological disorders. -
NO Inhibitor
Panaxcerol B is a monogalactosyl monoacylglyceride characterized as a nitric oxide (NO) inhibitor. It exhibits an IC50 of 59.4 μM in inhibiting NO production in lipopolysaccharide-stimulated RAW264.7 macrophage cells. This compound is valuable for research applications focused on inflammatory responses and related signaling pathways. -
NO Synthase Inhibitor
3-Amino-1,2,4-triazine acts as an inhibitor of nitric oxide (NO) synthase, thereby impacting NO production and modulating associated cellular signaling pathways. This compound is relevant for studying the role of NO in various biological processes and may aid in research applications focused on vascular function, neurobiology, and inflammation. Its inhibitory effects on nitrite secretion further enhance its utility in investigating nitric oxide-related mechanisms in biological systems. -
NO Inhibitor
(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid is a lanostane triterpenoid that serves as a nitric oxide (NO) inhibitor, demonstrating potent inhibitory effects on LPS-induced BV-2 microglia cells with an IC50 of 9.55 µM. This compound exhibits significant anti-inflammatory activity, making it a valuable tool for research applications focused on neuroinflammation and related pathways. -
iNOS Inhibitor
BYK 191023 dihydrochloride is a selective inhibitor of inducible nitric-oxide synthase (iNOS), targeting the enzyme's catalytic center. This compound plays a critical role in research focused on the regulation of nitric oxide production and its implications in inflammatory responses. Its application is vital for studying both in vitro and in vivo effects mediated by iNOS, making it an essential tool for investigations into related pathological conditions. -
hDDAH-1 Inhibitor
hDDAH-1-IN-1 is a potent and selective inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), functioning through non-amino acid catalytic site inhibition, with an inhibition constant (Ki) of 18 μM. By inhibiting DDAH, this compound regulates the metabolism of asymmetric dimethylarginine (ADMA), influencing nitric oxide production. This makes hDDAH-1-IN-1 valuable in research applications related to cardiovascular diseases, neurodegenerative disorders, and conditions where nitric oxide dysregulation plays a critical role. -
hDDAH-1 Inhibitor
hDDAH-1-IN-2 sulfate is a selective inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1). This compound has demonstrated low toxicity and high cell viability, making it suitable for advanced research applications. It is valuable for investigating the role of hDDAH-1 in cardiovascular diseases and other physiological processes influenced by nitric oxide metabolism. -
iNOS Inhibitor
L-NIL dihydrochloride is an inducible nitric oxide synthase (iNOS) inhibitor, exhibiting an IC50 value of 3.3 μM for miNOS. This compound demonstrates significant biological activity by curtailing nitric oxide production, which plays a critical role in inflammatory processes. L-NIL dihydrochloride is widely utilized in research to investigate the implications of nitric oxide in various pathophysiological conditions, making it an essential tool for studies related to inflammation and immune response. -
hDDAH-1 Inhibitor
hDDAH-1-IN-1 TFA is a selective non-amino acid inhibitor targeting human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), exhibiting a Ki of 18 μM. This compound demonstrates potent inhibition of the enzyme's catalytic activity, making it a valuable tool for studying the regulation of nitric oxide synthase and the metabolism of asymmetric dimethylarginines. Research applications include investigations into cardiovascular diseases, endothelial function, and polyamine metabolism.
