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Catalog No.
Product Name
Application
Product Information
Citations
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NO Synthase Inhibitor
Cycloneroside D is a novel sesquiterpene aminoglycoside identified from the deep-sea fungus Trichoderma sp. SCSIOW21, serving as a nitric oxide synthase inhibitor. It demonstrates significant anti-inflammatory activity, with an IC50 value of 42.0 μM for nitric oxide production inhibition in RAW 264.7 macrophage cells. This compound is suitable for research applications focusing on inflammatory pathways and nitric oxide-related signaling. -
NO Synthase Inhibitor
Phenylaminojuglone AJ-2 is a potent nitric oxide synthase inhibitor that modulates various targets, including soluble guanylate cyclase and calcium channels. It effectively blocks extracellular Ca2+ influx, thereby regulating the NO-sGC-cGMP signaling pathway and inhibiting both pharmacological and electromechanical contractions of smooth muscle. This compound is particularly relevant for research investigating intestinal spasm and related gastrointestinal disorders. -
AQP9 Inhibitor
HTS13286 is a selective inhibitor of aquaporin 9 (AQP9), targeting water and glycerol transport in cells. This compound effectively attenuates lipopolysaccharide (LPS)-induced nitric oxide (NO) production and reduces glucose output in response to inflammatory stimuli. HTS13286 is valuable for research applications related to endotoxin shock and the study of metabolic dysregulation in inflammatory conditions. -
NO Production Inhibitor
(-)-Sesamin 2,2'-diol is a nitric oxide (NO) production inhibitor, exhibiting an IC50 of 310 μM against LPS-induced NO production. This compound, isolated from the aerial parts of Isodon japonicus, effectively suppresses NO synthesis in LPS-stimulated macrophages while demonstrating a lack of cytotoxic effects. Its properties make it a valuable tool for research focusing on inflammatory responses and nitric oxide signaling pathways. -
nNOS-Capon Inhibitor
ZLc-002 is a selective inhibitor of nNOS-Capon coupling, primarily targeting the nitric oxide synthase pathway. This compound demonstrates significant potential in suppressing inflammatory nociception as well as chemotherapy-induced neuropathic pain. ZLc-002 is valuable for research applications related to anxiety disorders and inflammatory conditions, making it an essential reagent for exploring pain mechanisms and therapeutic strategies. -
Nitric Qxide Production Inhibitor
Mudanpioside F is a monoterpene glycoside that serves as an inhibitor of nitric oxide production, specifically targeting LPS-induced pathways. It displays potent activity with an IC50 of 18.65 ± 2.1 μM, making it a valuable tool for investigating nitric oxide modulation. This compound is particularly relevant in studies related to inflammation and immune response, providing insights into the signaling mechanisms involving nitric oxide. -
nNOS Inhibitor
Nω-allyl-L-arginine is a competitive and reversible inhibitor of neuronal nitric oxide synthase (nNOS). This compound effectively inactivates nNOS in a time-dependent manner while serving as a substrate that generates L-arginine, acrolein, and water. Its role in nitric oxide signaling pathways makes it valuable for research into neurovascular functions and related pathophysiological conditions. -
NO Synthase Inhibitor
L-NAME is a nitric oxide synthase (NOS) inhibitor with an IC50 of 70 μM. This compound acts as a precursor to the more potent NOS inhibitor L-NOARG, which has an IC50 of 1.4 μM. L-NAME requires hydrolysis by cellular esterases to achieve its full inhibitory activity. It is commonly utilized in research to induce hypertension and preeclampsia models, facilitating studies on cardiovascular health and nitric oxide signaling pathways. -
Neuroinflammation Inhibitors
Stephalonine P is a hasubanan-type alkaloid that serves as a neuroinflammation inhibitor. It exhibits significant anti-inflammatory properties by inhibiting nitric oxide production in lipopolysaccharide-activated BV2 microglia, with an IC50 value of 34.01 μM. By reducing microglial activation, Stephalonine P provides neuroprotective effects, which are particularly relevant in the context of stroke and other neuroinflammation-related diseases. This compound can be isolated from the plant Stephania japonica and is valuable for research into neuroinflammatory mechanisms and therapeutic interventions. -
NO Synthesis Inhibitor
Kadsulignan H is a lignan that functions as a nitric oxide (NO) synthesis inhibitor. It effectively inhibits NO production in BV-2 cells, demonstrating an IC50 value of 14.1 μM. This compound is valuable for research applications focused on inflammatory processes and neurological studies where modulation of nitric oxide levels is relevant. -
NO Synthase Inhibitor
Harzianol A is a potent inhibitor of nitric oxide (NO) synthase. Isolated from Trichoderma sp. SCSIOW21, this compound demonstrates significant anti-inflammatory activity by effectively reducing NO production. Harzianol A is suitable for research applications focused on nitrosative stress and inflammatory pathways. -
NO Synthase Inhibitor
L-NABE is a selective inhibitor of nitric oxide (NO) synthase, effectively modulating the production of nitric oxide in biological systems. This compound exhibits significant vasoconstrictive properties, contributing to endothelium-dependent vasoconstriction and inhibiting relaxation responses. L-NABE is primarily utilized in research to study vascular physiology and the role of nitric oxide in cardiovascular conditions. -
NO Synthase Inhibitor
Harzianoside A is a diterpene aminoglycoside that acts as a nitric oxide synthase inhibitor. It effectively reduces the production of nitric oxide, making it a valuable tool for investigating anti-inflammatory mechanisms. This compound is useful in research focused on inflammation and related pathophysiological conditions. -
NO Inhibitor
Geranyl ferulate, a derivative of ferulic acid isolated from Zingiber officinale, serves as a nitric oxide (NO) inhibitor. This compound demonstrates a significant inhibitory effect on NO production, making it valuable for research related to nitric oxide signaling pathways. Its potential applications extend to studies focused on inflammatory processes, vascular biology, and related therapeutic interventions. -
Inflammatory Pathway Inhibitor
(E)-Sinapoyl glucose is an inhibitor of inflammatory pathways, specifically targeting nitric oxide (NO) production. It demonstrates an IC50 value of 38.32 µM in RAW 264.7 macrophage cells, highlighting its potential in modulating inflammatory responses. This compound is valuable for research into inflammatory diseases and their underlying mechanisms. -
NO Inhibitor
Thunalbene is a stilbene derivative that acts as a nitric oxide (NO) inhibitor. It demonstrates a moderate inhibitory effect on nitric oxide production, making it a valuable tool for studies examining NO-related pathways. Additionally, Thunalbene has been shown to be non-cytotoxic, enabling its use in various biological assays without compromising cell viability. -
iNOS/ICAM-1 Inhibitor
Aloenin aglycone is an inhibitor of iNOS and ICAM-1, derived from aloe exudate. It effectively suppresses TNFα-induced NF-κB transcriptional activity with an IC50 of 18.7 μM. Additionally, at a concentration of 10 μM, it significantly reduces the expression of both inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) in HepG2 cells following TNFα stimulation. This compound serves as a valuable tool for investigating inflammatory pathways and potential therapeutic interventions in related conditions. -
NO Production Inhibitor
6-Methoxynaringenin is a natural flavonoid that functions as an inhibitor of nitric oxide (NO) production, exhibiting an IC50 of 25.8 μM. This compound is valuable for research focused on cardiovascular health and inflammation, where NO plays a critical role. Its ability to modulate NO levels makes it an important tool for studying various biochemical pathways and therapeutic interventions. -
NO Synthase Inhibitor
Ronopterin is a nitric oxide synthase (NOS) inhibitor, primarily utilized in research investigating the pathophysiology of urogenital and neurological disorders. By inhibiting NO production, Ronopterin modulates crucial signaling pathways, making it a valuable tool for studying conditions linked to dysregulated nitric oxide signaling. Applications include exploring the role of NO in various diseases and assessing therapeutic strategies targeting NOS pathways. -
SPSB2-iNOS Inhibitor
SPSB2-iNOS inhibitory cyclic peptide-3 is a selective inhibitor targeting the interaction between SPSB2 and inducible nitric oxide synthase (iNOS). This compound binds to the SPSB2 site on iNOS with a dissociation constant (KD) of 7 nM. It demonstrates significant biological activity in modulating nitric oxide production and has potential applications in studies related to inflammation and oxidative stress. -
NOS Inhibitor
NOS-IN-2 is a selective inhibitor of nitric oxide synthase (NOS), primarily targeting inducible nitric oxide synthase (iNOS) with an IC50 of 20 µM, while sparing endothelial nitric oxide synthase (eNOS). Its low toxicity profile makes it suitable for research in inflammatory disorders and related pathways. NOS-IN-2 is an important tool for investigating the role of nitric oxide in various biological processes and for developing therapeutic strategies for conditions associated with elevated iNOS activity. -
NO Synthase Inhibitor
GW 273629 is a selective nitric oxide synthase inhibitor that effectively modulates nitric oxide production. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research investigating inflammation-related pathways and conditions. Its specificity for nitric oxide synthase positions it as a suitable reagent for studies aimed at understanding the role of nitric oxide in various biological processes. -
NO Synthase Inhibitor
Cycloneroside C is a sesquiterpene aminoglycoside that functions as a nitric oxide synthase inhibitor. In studies utilizing RAW 264.7 macrophage cells, it demonstrated an IC50 value of 57.1 μM for the inhibition of nitric oxide production. This compound is primarily applied in research focused on anti-inflammatory mechanisms and potential therapeutic interventions. -
NO Synthase Inhibitor
Harzianoside B is a diterpene aminoglycoside known for its role as a nitric oxide (NO) synthase inhibitor. It effectively reduces NO production, demonstrating an IC50 value near the maximum tested concentration of 100 µM in RAW 264.7 macrophage cells. This compound is valuable for research into anti-inflammatory mechanisms and therapeutic applications. -
NO Synthesis Inhibitor
Schiarisanrin A is a lignan that acts as an inhibitor of nitric oxide (NO) synthesis. It demonstrates a significant inhibitory effect on NO production in BV-2 cells, with an IC50 value of 9.6 μM. This compound may serve as a valuable tool in research focused on inflammatory pathways and neuroprotection. -
iNOS Inhibitor
Myricananin A is a selective inhibitor of inducible nitric oxide synthase (iNOS), effectively modulating nitric oxide production. This compound demonstrates significant anti-inflammatory properties, making it valuable for research in inflammation-related pathways and conditions. Myricananin A serves as a critical tool for elucidating the role of iNOS in various biological processes and may aid in the development of therapeutic strategies targeting iNOS-related diseases. -
NO Synthase Inhibitor
Chloranthalactone E is a labdane diterpene that acts as an inhibitor of nitric oxide synthase (NOS). It effectively reduces nitric oxide production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages, making it a valuable tool for studying inflammatory pathways. This compound is useful in research focused on immune responses and the modulation of macrophage activity. -
NO Synthase Inhibitor
Mercaptoethylguanidine (MEG) dihydrobromide is a selective inhibitor of inducible nitric oxide synthase, acting as a peroxynitrite scavenger. This compound exhibits significant anti-inflammatory properties, making it a valuable tool for research into inflammatory bowel diseases and related conditions. Its ability to modulate nitric oxide production makes MEG an important reagent for studies focusing on nitric oxide-related pathologies. -
NO Production Inhibitor
Dimeric coniferyl acetate is an inhibitor of nitric oxide (NO) production, exhibiting an IC50 value of 7.9 μM in BV-2 microglial cells. This compound is valuable for research applications aimed at understanding the regulation of NO synthesis and its implications in neuroinflammatory processes. Its specificity and potency make it a useful tool for studying the role of NO in cellular signaling and neurobiology. -
Nitric Oxide Inhibitor
(+)-Hannokinol is a nitric oxide inhibitor derived from the fruit of AMOMUM TSAO-KO, a member of the ginger family. This compound effectively inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia, making it a valuable tool for studies related to neuroinflammation and oxidative stress. Its biological activity contributes to research in various fields, including neurobiology and immunology. -
NOS Inhibitor
Guanidino ethyl disulfide is a selective nitric oxide synthase (NOS) inhibitor, showing EC50 values of 110 μM for iNOS, 630 μM for eNOS, and 180 μM for bNOS. This compound effectively inhibits nitrite production in J774.2 macrophages, making it a valuable tool for studying mechanisms of nitric oxide modulation. Guanidino ethyl disulfide can be utilized in research related to circulatory shock, inflammation, and neurological disorders. -
Nitric Oxide Inhibitor
Kansuinine E is a jatrophane-type diterpenoid that acts as a nitric oxide inhibitor with an IC50 of 6.3 μM. Isolated from the roots of Euphorbia kansui, this compound demonstrates significant biological activity by modulating nitric oxide levels. Kansuinine E is primarily utilized in research applications focusing on vascular biology and the study of nitric oxide-related pathways. -
NO Inhibitor
Isolupalbigenin is a nitric oxide (NO) inhibitor that exhibits significant anti-proliferative activity against HL-60 human leukemia cells, with an IC50 value of 5.1 μM. This compound is useful in research applications focused on the modulation of nitric oxide signaling pathways and the exploration of therapeutic strategies for leukemia and related disorders. -
NO Production Inhibitor
O-Acetylschisantherin L is a natural lignan that serves as an inhibitor of nitric oxide (NO) production. It effectively suppresses LPS-induced NO production in BV-2 cells, demonstrating an IC50 value of 23.1 μM. This compound is useful in research focused on neuroinflammation and associated signaling pathways. -
NOS Inhibitor
NOS-IN-3 is a selective inhibitor of nitric oxide synthase (NOS) with a notable affinity for inducible nitric oxide synthase (iNOS), exhibiting an IC50 of 4.6 μM, while sparing endothelial nitric oxide synthase (eNOS). This compound demonstrates minimal toxicity, making it suitable for investigations into diseases associated with the inducible isoform, such as septic shock. NOS-IN-3 is a valuable tool for elucidating the role of iNOS in various pathological conditions. -
NO Production Inhibitor
Valeriandoid F is an iridoid compound that acts as a potent inhibitor of nitric oxide (NO) production, exhibiting an IC50 value of 0.88 μM. This reagent possesses anti-inflammatory and antiproliferative properties, making it beneficial for studies related to inflammation and cancer research. Its ability to modulate NO levels may also provide insights into various pathological conditions associated with dysregulated nitric oxide signaling. -
NO Inhibitor
Britannilactone diacetate is a notable nitric oxide (NO) inhibitor, demonstrating significant efficacy in reducing NO production induced by lipopolysaccharide (LPS) in BV-2 microglial cells, with an effective concentration (EC50) of 6.3 μM. This compound is characterized by its favorable penetration across the blood-brain barrier, along with promising absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles, making it a valuable tool for investigating NO-related neuroinflammatory processes. Its unique mechanisms and properties position it for various research applications in neurobiology and pharmacology. -
iNOS Inhibitor
BYK 191023 is a selective inhibitor of inducible nitric-oxide synthase (iNOS) that functions as an L-arginine competitive antagonist, exhibiting an IC50 value of 86 nM for iNOS, while displaying significantly higher IC50 values of 17 µM and 162 µM for neuronal (nNOS) and endothelial (eNOS) nitric-oxide synthases, respectively. This compound is vital for studying the role of iNOS in various pathological conditions and demonstrates potential applications in inflammation research and related disease models. -
NO Production Inhibitor
9-Hydroxy-α-lapachone is a natural phenolic compound that serves as an effective nitric oxide (NO) production inhibitor. It demonstrates significant inhibitory activity, with an IC50 value of 4.64 µM, against LPS-induced NO production in RAW 264.7 macrophage cells. This compound is utilized in research applications focused on understanding inflammatory responses and nitric oxide signaling pathways. -
NO Synthase Inhibitor
1,3-PBIT dihydrobromide is a selective inhibitor of inducible nitric oxide synthase (iNOS), demonstrating a Ki value of 47 nM. In contrast, it shows reduced inhibition for endothelial (eNOS) and neuronal nitric oxide synthase (nNOS), with Ki values of 9 µM and 0.25 µM, respectively, for purified human enzymes. While it effectively inhibits iNOS in vitro, its cellular activity may be limited by membrane permeability, making it primarily useful for biochemical studies on nitric oxide pathways and their related regulatory mechanisms. -
NO Production Inhibitor
Sinomenine N-oxide is a potent inhibitor of nitric oxide (NO) production, exhibiting an IC50 value of 23.04 μM. This compound demonstrates significant anti-angiogenic, anti-inflammatory, and anti-rheumatic properties, making it valuable for research in cardiovascular and inflammatory diseases. Its mechanisms may offer insights into therapeutic approaches for conditions characterized by excess NO production. -
NO Inhibitor
Diplacol is a geranylated flavanone that functions as a nitric oxide (NO) inhibitor. Isolated from Paulownia coreana UYEKI, Diplacol exhibits notable anti-inflammatory activity. It effectively reduces NO production in LPS-stimulated Raw264.7 macrophage cells, with an IC50 value of 4.53 μM, making it a valuable reagent for studies focusing on inflammation and related signaling pathways. -
NOS Inhibitor
L-NAPNA is a selective nitric oxide synthase (NOS) inhibitor, demonstrated to have an IC50 of 1.4 μM. It exhibits significant analgesic effects, as evidenced by its ability to reduce formalin-induced paw licking behavior in mice (ED50 of 57.2 mg/kg) and diminish acetic acid-induced abdominal writhing (ED50 of 25 mg/kg). This compound is valuable for exploring therapeutic approaches in research focused on central nervous system disorders. -
NO Synthase Inhibitor
Corydaldine is an alkaloid that acts as an inhibitor of nitric oxide synthase (NOS). It has been shown to effectively reduce nitric oxide production in BV2 microglial cells upon stimulation with lipopolysaccharide (LPS). This compound is relevant for research focusing on neuroinflammation and the roles of nitric oxide in various neurodegenerative diseases. -
iNOS Inhibitor
AR-C102222 is a spirocyclic fluoropiperidine quinazoline that selectively inhibits inducible nitric oxide synthase (iNOS). This compound demonstrates significant potential in mitigating neuropathic pain by reducing excessive nitric oxide production. Its specificity for iNOS makes it a valuable tool for researchers investigating the role of nitric oxide in pain pathology and related therapeutic interventions. -
iNOS Inhibitor
FR260330 is a selective, orally active inhibitor of inducible nitric oxide synthase (iNOS), functioning by suppressing iNOS dimerization. This compound significantly reduces nitric oxide accumulation in rat splenocytes and human DLD-110 cells, with IC50 values of 27 nM and 10 nM, respectively. FR260330 has demonstrated efficacy in ameliorating lipopolysaccharide-induced inflammatory responses in rat models, making it a valuable tool for researchers investigating inflammatory diseases and related pathways. -
NO Production Inhibitor
Anhydronotoptol is a potent inhibitor of nitric oxide (NO) production. It effectively inhibits NO generation in RAW 264.7 cells induced by lipopolysaccharide (LPS), with an IC50 value of 36.6 μM. This compound is valuable for research applications focused on inflammation and related signaling pathways. -
iNOS Inhibitor
1-Heptadecanoyl-rac-glycerol is an iNOS inhibitor that exhibits anti-inflammatory activity. By suppressing the expression of inducible nitric oxide synthase (iNOS), it effectively reduces inflammation. This compound is suitable for research applications focused on inflammatory diseases and related pathologies. -
NO Synthase Inhibitor
S-MTC acetate (S-Methyl-L-thiocitrulline acetate) is a potent inhibitor of inducible nitric oxide synthase (iNOS), selectively inhibiting iNOS while preserving the activity of constitutive nitric oxide synthase (nNOS). This compound is valuable for studying the roles of nitric oxide in various physiological and pathological processes, particularly in inflammation and neuroprotection research. Its specificity makes it an important tool for investigating the differential effects of nitric oxide in cellular signaling pathways. -
NO Release Inhibitor
Schisanchinin D is an NO release inhibitor derived from the fruits of Schisandra chinensis. It effectively inhibits the release of nitric oxide (NO) in lipopolysaccharide (LPS)-activated primary murine BV2 microglia cells. This compound holds potential for research in neurodegenerative diseases, particularly Alzheimer's disease (AD), due to its impact on microglial activation and neuroinflammatory processes.
