SCR-4026 is a neuroprotective agent that effectively penetrates the blood-brain barrier. It exerts its protective effects by disrupting the interaction between neuronal nitric oxide synthase (nNOS) and PSD9, with an IC50 of 6.3 μM. SCR-4026 has been shown to mitigate excitotoxic damage induced by N-methyl-D-aspartate (NMDA) in primary cortical neurons and offers protection in oxygen-glucose deprivation (OGD) models. Additionally, it reduces cerebral infarct volume in the rat middle cerebral artery occlusion (MCAO) reperfusion model, making it a valuable tool for stroke research.
SCR-4026 is a neuroprotective agent that effectively penetrates the blood-brain barrier. It exerts its protective effects by disrupting the interaction between neuronal nitric oxide synthase (nNOS) and PSD9, with an IC50 of 6.3 μM. SCR-4026 has been shown to mitigate excitotoxic damage induced by N-methyl-D-aspartate (NMDA) in primary cortical neurons and offers protection in oxygen-glucose deprivation (OGD) models. Additionally, it reduces cerebral infarct volume in the rat middle cerebral artery occlusion (MCAO) reperfusion model, making it a valuable tool for stroke research.
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