Losartan-d9

Catalog No.: A58963
Stable Isotope
Losartan-d9 is a deuterated form of Losartan, which serves as an angiotensin II receptor antagonist. It effectively competes with angiotensin II for binding to AT1 receptors, demonstrating an IC50 value of 20 nM. This stable isotope is valuable in pharmacokinetic studies and metabolic research, providing insights into drug metabolism and pharmacodynamics.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionLosartan-d9 is a deuterated form of Losartan, which serves as an angiotensin II receptor antagonist. It effectively competes with angiotensin II for binding to AT1 receptors, demonstrating an IC50 value of 20 nM. This stable isotope is valuable in pharmacokinetic studies and metabolic research, providing insights into drug metabolism and pharmacodynamics.
Product Information
Catalog NumA58963
FormulaC22H14D9ClN6O
Molecular Weight431.97
CAS Number1030937-18-8
SMILES[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1=NC(Cl)=C(CO)N1CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2
SynonymsDuP-753-d9
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