AM404-d4 is a deuterium-labeled analog of AM404, which functions as an endocannabinoid reuptake inhibitor. By blocking the transport of anandamide, AM404 exhibits biological activity with an IC50 in the low micromolar range. Additionally, it demonstrates vasodilatory effects in rat isolated hepatic arteries contracted with phenylephrine, with a pEC50 of 7.4, indicating an EC50 of 0.04 μM. This compound is of particular interest in neuroprotection and cannabinoid research applications.
AM404-d4 is a deuterium-labeled analog of AM404, which functions as an endocannabinoid reuptake inhibitor. By blocking the transport of anandamide, AM404 exhibits biological activity with an IC50 in the low micromolar range. Additionally, it demonstrates vasodilatory effects in rat isolated hepatic arteries contracted with phenylephrine, with a pEC50 of 7.4, indicating an EC50 of 0.04 μM. This compound is of particular interest in neuroprotection and cannabinoid research applications.
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