Apafant-d8 is a deuterium-labeled derivative of Apafant, a potent antagonist of platelet-activating factor (PAF). It effectively inhibits PAF binding to human PAF receptors with an IC50 value of 9.9 nM. Apafant-d8 enhances the expression of PAF receptor, α-globin, and β-globin genes while reducing c-myb gene expression. This compound also demonstrates protective effects against alkyl-PAF-mediated cytotoxicity, making it valuable for research in cellular protection and receptor signaling.
Apafant-d8 is a deuterium-labeled derivative of Apafant, a potent antagonist of platelet-activating factor (PAF). It effectively inhibits PAF binding to human PAF receptors with an IC50 value of 9.9 nM. Apafant-d8 enhances the expression of PAF receptor, α-globin, and β-globin genes while reducing c-myb gene expression. This compound also demonstrates protective effects against alkyl-PAF-mediated cytotoxicity, making it valuable for research in cellular protection and receptor signaling.
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