Tolmetin-d3

Catalog No.: A64530
Stable Isotope
Tolmetin-d3 is a deuterium-labeled analog of Tolmetin, a potent non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase (COX) enzymes. With IC50 values of 0.35 μM for human COX-1 and 0.82 μM for COX-2, Tolmetin effectively modulates inflammatory pathways. This stable isotope variant is ideal for research applications involving pharmacokinetics, metabolic studies, and the assessment of drug interactions.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTolmetin-d3 is a deuterium-labeled analog of Tolmetin, a potent non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase (COX) enzymes. With IC50 values of 0.35 μM for human COX-1 and 0.82 μM for COX-2, Tolmetin effectively modulates inflammatory pathways. This stable isotope variant is ideal for research applications involving pharmacokinetics, metabolic studies, and the assessment of drug interactions.
Product Information
Catalog NumA64530
FormulaC15H12D3NO3
Molecular Weight260.30
CAS Number1184998-16-0
SMILESC(=O)(C=1N(C([2H])([2H])[2H])C(CC(O)=O)=CC1)C2=CC=C(C)C=C2
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