Propiconazole-d7 is a deuterium-labeled analog of the triazole fungicide Propiconazole, which primarily targets the enzyme lanosterol 14α-demethylase, inhibiting the biosynthesis of ergosterol and disrupting fungal cell membranes. This compound demonstrates significant antifungal activity against species such as Trichophyton deformans and Rhizopus stolonifer, with effective doses of 0.073 and 4.6 μg/mL, respectively. Additionally, Propiconazole-d7 enhances the generation of reactive oxygen species (ROS), making it valuable for studies on oxidative stress in fungal pathogenesis and resistance mechanisms. This stable isotope-labeled compound is ideal for research applications requiring precise tracking of Propiconazole in biological systems.
Propiconazole-d7 is a deuterium-labeled analog of the triazole fungicide Propiconazole, which primarily targets the enzyme lanosterol 14α-demethylase, inhibiting the biosynthesis of ergosterol and disrupting fungal cell membranes. This compound demonstrates significant antifungal activity against species such as Trichophyton deformans and Rhizopus stolonifer, with effective doses of 0.073 and 4.6 μg/mL, respectively. Additionally, Propiconazole-d7 enhances the generation of reactive oxygen species (ROS), making it valuable for studies on oxidative stress in fungal pathogenesis and resistance mechanisms. This stable isotope-labeled compound is ideal for research applications requiring precise tracking of Propiconazole in biological systems.
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