Lapatinib-d4 is a deuterium-labeled derivative of Lapatinib, a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains. It exhibits IC50 values of 10.2 nM for EGFR and 9.8 nM for ErbB-2, demonstrating its superior efficacy in inhibiting these targets. This stable isotope compound is primarily utilized in pharmacokinetic and metabolic studies to trace the absorption and distribution of Lapatinib in biological systems.
Lapatinib-d4 is a deuterium-labeled derivative of Lapatinib, a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains. It exhibits IC50 values of 10.2 nM for EGFR and 9.8 nM for ErbB-2, demonstrating its superior efficacy in inhibiting these targets. This stable isotope compound is primarily utilized in pharmacokinetic and metabolic studies to trace the absorption and distribution of Lapatinib in biological systems.
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