2-Acetamidophenol-d3 is a deuterium-labeled derivative of 2-Acetamidophenol, primarily utilized as a stable isotope. This compound influences ferroptosis and glutathione metabolism pathways, demonstrating anti-atherosclerotic properties. In zebrafish models of hyperlipidemia, it effectively reduces total cholesterol and triglyceride levels with IC50 values of 30 μM and 40 μM, respectively. Additionally, 2-Acetamidophenol-d3 enhances the expression of glutathione synthesis-related genes and mitigates the accumulation of reactive oxygen species, ultimately inhibiting the formation of foam cells through reduced macrophage uptake of oxidized low-density lipoprotein.
2-Acetamidophenol-d3 is a deuterium-labeled derivative of 2-Acetamidophenol, primarily utilized as a stable isotope. This compound influences ferroptosis and glutathione metabolism pathways, demonstrating anti-atherosclerotic properties. In zebrafish models of hyperlipidemia, it effectively reduces total cholesterol and triglyceride levels with IC50 values of 30 μM and 40 μM, respectively. Additionally, 2-Acetamidophenol-d3 enhances the expression of glutathione synthesis-related genes and mitigates the accumulation of reactive oxygen species, ultimately inhibiting the formation of foam cells through reduced macrophage uptake of oxidized low-density lipoprotein.
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