Terbinafine-d3 is a deuterium-labeled derivative of the antifungal agent Terbinafine, a potent non-competitive inhibitor of squalene epoxidase with a Ki of 30 nM, effective against Candida species. This compound demonstrates additional antibacterial activity against various Gram-positive and Gram-negative bacteria. Terbinafine-d3 includes an alkyne functional group, making it suitable for click chemistry applications, specifically in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. This compound is valuable for research in antifungal therapeutic development and mechanistic studies.
Terbinafine-d3 is a deuterium-labeled derivative of the antifungal agent Terbinafine, a potent non-competitive inhibitor of squalene epoxidase with a Ki of 30 nM, effective against Candida species. This compound demonstrates additional antibacterial activity against various Gram-positive and Gram-negative bacteria. Terbinafine-d3 includes an alkyne functional group, making it suitable for click chemistry applications, specifically in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. This compound is valuable for research in antifungal therapeutic development and mechanistic studies.
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